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Lcms Operator Jobs (NOW HIRING)

Synectics Inc

LCMS Scientist

North Chicago, IL

$45 - $55/hr

Proven experience operating and troubleshooting Agilent HPLCs, Leap/CTC PAL autosamplers and AB Sciex Mass Spectrometers * Detail oriented and committed to generating high-quality results within ...

BioIVT

Senior Scientist - Mass Spectrometry

Santa Clara, CA · On-site

$130K - $135K/yr

The Senior Scientist serves as a lead scientist and analytical subject matter expert specializing in LCMS and HRMS systems. This role is responsible for independently operating and troubleshooting ...

Fresenius Kabi

Sr Scientist

Melrose Park, IL · On-site

$92K - $95K/yr

Skills in chromatography, such as HPLC, LCMS, LCMS-MS, GCMS, SEC-MALS, CD, NMR, and related ... and operating basic lab instruments are preferred. May require experience in Cell Based assay ...

Fresenius Kabi USA, LLC

Sr Scientist

Melrose Park, IL

$92K - $95K/yr

Skills in chromatography, such as HPLC, LCMS, LCMS-MS, GCMS, SEC-MALS, CD, NMR, and related ... and operating basic lab instruments are preferred. May require experience in Cell Based assay ...

Freseniusglobal

Sr Scientist

Melrose Park, IL · On-site

$92K - $95K/yr

Skills in chromatography, such as HPLC, LCMS, LCMS-MS, GCMS, SEC-MALS, CD, NMR, and related ... and operating basic lab instruments are preferred. May require experience in Cell Based assay ...

Altasciences

LCMS Scientist II

Columbia, MO · On-site

Follow Alta's Standard Operating Procedures (SOPs), ensure compliance with GLP, ALCOA++, USDA, and AAALAC guidelines, and can identify areas for improvement. * Perform routine laboratory maintenance ...

Dyne Therapeutics

Scientist, RNA Chemistry

Waltham, MA · On-site

Interpretation of analytical data (HPLC, LCMS)to enableimprovedpurity and yields of synthesized ... Hands-on experience operating oligonucleotide synthesis and purification platforms, including ...

Danaher

Senior Scientist, Oligo Chemistry

Sunnyvale, CA · On-site

At Integrated DNA Technologies (IDT), one of Danaher's 15+ operating companies, our work saves ... Demonstrated experience using LCMS (highresolution preferred) to characterize oligos and diagnose ...

Altasciences

LCMS Scientist II

Columbia, MO

Follow Alta's Standard Operating Procedures (SOPs), ensure compliance with GLP, ALCOA++, USDA, and AAALAC guidelines, and can identify areas for improvement. * Perform routine laboratory maintenance ...

Access Medical Labs

LCMS Medical Technologist

Jupiter, FL · On-site

$35 - $45/hr

Operate and maintain LC-MS instrumentation and associated equipment in accordance with standard operating procedures (SOPs) and regulatory guidelines * Interpret LC-MS data, troubleshoot technical ...

Access Labs LLC

LCMS Medical Technologist

Jupiter, FL · On-site

$35 - $45/hr

Operate and maintain LC-MS instrumentation and associated equipment in accordance with standard operating procedures (SOPs) and regulatory guidelines * Interpret LC-MS data, troubleshoot technical ...

Pride Global

MLT

Zionsville, IN

... to departmental Standard Operating Procedures. 7. Monitor, operate, and troubleshoot ... Experience with Mass Spec, HPLC, and LCMS are highly preferred * Molecular or Analytical Chemistry ...

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Lcms Operator information

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$23

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How much do lcms operator jobs pay per hour?

As of Jun 4, 2026, the average hourly pay for lcms operator in the United States is $23.04, according to ZipRecruiter salary data. Most workers in this role earn between $18.03 and $21.88 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as an LCMS Operator, and why are they important?

To thrive as an LCMS Operator, you need a solid background in analytical chemistry, attention to detail, and experience with laboratory practices, often supported by a degree in chemistry or a related field. Familiarity with liquid chromatography-mass spectrometry (LC-MS) instruments, data analysis software, and relevant quality control protocols is essential. Strong problem-solving skills, organization, and effective communication help you troubleshoot issues and collaborate with team members. These skills and qualifications ensure accurate sample analysis, reliable data, and efficient laboratory operations.

What are some common challenges LCMS Operators face when troubleshooting instrument performance issues?

LCMS Operators often encounter challenges such as inconsistent results, signal instability, or unexpected background noise during routine analyses. These issues may stem from factors like contaminated solvents, worn-out columns, or clogged ion sources. Successful troubleshooting typically involves methodically checking each component, maintaining detailed logs, and collaborating closely with analytical chemists and maintenance teams. Staying up to date with manufacturer protocols and regular preventive maintenance are key to minimizing downtime and ensuring reliable data generation.

What are LCMS Operators?

LCMS Operators are professionals who operate Liquid Chromatography-Mass Spectrometry (LC-MS) instruments, which are used to analyze chemical compounds in a variety of samples. They are responsible for preparing samples, running the LC-MS equipment, maintaining the instruments, and interpreting data to ensure accurate results. LCMS Operators often work in laboratories within industries such as pharmaceuticals, environmental science, food safety, and forensics. Their expertise is crucial for identifying and quantifying chemical substances in research and quality control processes.

What is the difference between Lcms Operator vs Analytical Chemist?

AspectLcms OperatorAnalytical Chemist
Required CredentialsAssociate degree or relevant certification, training in chromatographyBachelor's degree in chemistry or related field, often with advanced certifications
Work EnvironmentLaboratory setting, operating chromatography instrumentsLaboratory, research, and development environments, performing complex analyses
Employer & Industry UsagePharmaceutical, biotech, environmental testing labsPharmaceutical, chemical manufacturing, research institutions
Common Search & ComparisonOften compared for entry-level roles in labsMore research-focused, higher education requirements

The main difference between an Lcms Operator and an Analytical Chemist lies in their responsibilities and qualifications. Lcms Operators typically handle instrument operation and basic data collection, requiring less advanced education. Analytical Chemists perform complex analyses, interpret data, and often hold higher degrees. Both roles are vital in laboratory settings, but they differ in scope and expertise.

More about Lcms Operator jobs
What job categories do people searching Lcms Operator jobs look for? The top searched job categories for Lcms Operator jobs are:
Lcms Operator jobs near you
Infographic showing various Lcms Operator job openings in the United States as of May 2026, with employment types broken down into 97% Part Time, 1% Temporary, and 2% Nights. Highlights an 92% Physical, 1% Hybrid, and 7% Remote job distribution, with an average salary of $47,930 per year, or $23 per hour.
LCMS Scientist

LCMS Scientist

Synectics Inc

North Chicago, IL

$45 - $55/hr

Full-time

Medical, Dental, Vision, Retirement

Posted 11 days ago

Job description

Duties:

  • Responsible for non-regulated quantitative LC-MS/MS bioanalysis of small molecules from in vivo and in vitro samples, including extraction, data analysis and interpretation.

  • Perform high throughput quantitative in vivo and in vitro LC-MS/MS analysis, troubleshooting and problem solving of small molecule and peptides from various bio-matrices.

  • Operate, perform routine maintenance, and hands-on troubleshooting of AB Sciex LC-MS/MS systems.

  • Maintain excellent documentation of all work including LIMS, test methods, and protocols.

  • Work closely with multiple teams across Discovery and DMPK-BA to support bioanalysis.

Qualifications:

  • Bachelors, Masters, or Ph.D. in Biochemistry, Analytical Chemistry, or related discipline typically with 8+ (BS), 6+ (MS), or 0+ (PhD) years of relevant academia/pharmaceutical experience.

  • Proven method development experience using various extraction, chromatographic and analytical methodologies.

  • Proven experience with quantitative bioanalysis of small molecules.

  • Proven experience operating and troubleshooting Agilent HPLCs, Leap/CTC PAL autosamplers and AB Sciex Mass Spectrometers

  • Detail oriented and committed to generating high-quality results within tight deadlines and across different projects.

  • Proven ability to work independently or under minimal supervision in a high-throughput environment to design and conduct experiments, interpret, document, and communicate results, as well as in a team environment to collaborate successfully across other groups within R&D.

  • Strong communication, interpersonal, and presentation skills.

  • Work experience in regulated bioanalysis and/or CRO Facility settings is a plus.

  • Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.

  • Learns fast, grasps the "essence" and can change course quickly where indicated.

  • Raises the bar and is never satisfied with the status quo.

  • Creates a learning environment, open to suggestions and experimentation for improvement.

  • Embraces the ideas of others, nurtures innovation and manages innovation to reality.

  • Quantitative LC-MS experience

  • Proven record of independent work

  • Understanding of small molecule analysis in biomatrix

  • Understanding of peptides and proteins in biomatrix is a plus

  • Reverse phase method development is a plus

  • First Shift, Mon-Fri, 8am - 5pm (possibility of earlier than 8am depending on job tasks)

Benefits:

Healthcare Insurance: Synectics offers eligible employees and their dependents healthcare coverage through BlueCross BlueShield of Illinois. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics. Premiums are subsidized by Synectics.

Dental Insurance: Synectics offers eligible employees and their dependents a dental plan through MetLife. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.

Vision Insurance: Synectics offers eligible employees vision insurance through VSP. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.

401(k) Plan: The Synectics Inc. Investment Savings Retirement Plan. Synectics offers all employees who are 21 years of age or older the opportunity to invest in the 401(k) Plan on the first of the month following at least 1 calendar year after employment begins.

Synectics is an equal opportunity employer.

Company Description

Synectics is a leading staffing and workforce solutions company dedicated to connecting exceptional talent with top organizations. We specialize in IT, engineering, finance, healthcare, and professional services recruitment, offering both contract and permanent staffing solutions. With a people-first approach, we focus on understanding the unique needs of our clients and candidates to create long-term, successful matches. Our mission is to empower businesses with the right talent while helping professionals achieve rewarding career opportunities