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Position Objective: The Nuclear Magnetic Resonance (NMR) Spectroscopist contractor in the Analytical Chemistry Core (ACC), Division of Preclinical Innovation (DPI), NCATS, provides analytical chemistry support for translational research. The position requires expertise in solution-state NMR spectroscopy for small molecules and/or proteins. Responsibilities include operating and maintaining high-field NMR instruments; performing structural characterization, purity assessments, concentration and binding studies; developing new NMR methods; preparing samples; troubleshooting instrumentation, including cryogen fills; analyzing and interpreting spectral data; and training staff in instrument operation and NMR applications.

Duties and Responsibilities:

• Provide support for the ACC NMR Spectroscopy laboratory, which includes the operation of four (4) 400 MHz spectrometers and one (1) 600 MHz spectrometer 1

• Perform general maintenance and upkeep of equipment and instrumentation.

• Perform instrument quality control to ensure proper function.

• Collect and review data; analyze and interpret data and results.

• Conduct and write literature reviews for current and future projects.

• Work with staff in identity, purity and stability analysis.

• Prepare samples of various modalities prior to NMR analysis

• Conduct various 1D, 2D, nD, and VT NMR experiments, as well as perform spectral analysis and interpretation for structure verification, conformational analysis, chromatographic and isotopic purity analysis, and impurity identification 2

• Perform weekly liquid nitrogen fills and quarterly helium fills of the NMR magnets

• Utilize in-house compound tracking system; enter and review data.

• Write papers and abstracts detailing research efforts and results for publication in peer-reviewed journals. Prepare summaries, reports and presentations based on findings

• Perform both routine and specialized laboratory procedures of moderate to high complexity.

• Demonstrate and maintain current knowledge of NMR spectroscopy and associated instrumentation, providing subject matter expertise to internal and external collaborators. 3

• Assesses methods and procedures for use in experiments, and makes modifications and improvements to resolve problems and meet

• specific needs.

• Maintains accurate, detailed records of experiments, and evaluates and interprets results for validity and scientific meaning.

• Provide training to staff on the proper usage and maintenance of mass spectrometry instrumentation and equipment.

• Provide general and advanced training on mass spectrometry techniques, methods, and protocols.

• Train staff on the proper usage of NMR spectrometers for obtaining routine NMR spectra. 5

• Develop and document new procedures.

• Develop and implement novel methods and platforms for NMR sample preparation and analysis of various modalities, including small molecules, peptides, and proteins, utilizing automation and high-throughput technologies. 4

• Monitor and report on all safety issues.

• Ensure all raw NMR data are properly retained.

• Meet with lab members to present updates – Weekly

• Perform and document activities supporting nuclear magnetic resonance (NMR) spectroscopy operations, including instrument maintenance, liquid nitrogen and helium fills, equipment servicing and repair, sample preparation, data acquisition, processing, analysis, and spectral interpretation. Generates and organizes scientific data, figures, and tables; conducts literature reviews; prepares technical reports, manuscripts, presentations, posters, and operational manuals; and develops and refines analytical methods, procedures, workflows, and research platforms to support ongoing scientific and translational research programs.

Qualifications

Basic Qualifications:

• Ph.D. in Chemistry, Biophysics, or related discipline

• Direct experience with NMR spectrometers (Bruker, JEOL, and/or Agilent)

• Experience with saturation transfer difference (STD); binding affinity; hydrogen-deuterium exchange (HDX); residual dipolar coupling (RDC); relaxation analysis

• Experience with fragment screening, protein sample preparation, and/or automation systems

• Experience with NMR acquisition software and NMR data processing software

• Skilled in Chemdraw, GraphPad Prism, MOE, PyMOL, Python, R

Preferred Qualifications:

• Ability to communicate effectively, orally and in writing, with non-technical and technical staff

• Detail-oriented and possess strong organizational skills with the ability to prioritize multiple tasks and projects

*This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required by this position.

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

GAP Solutions provides reasonable accommodations to qualified individuals with disabilities. If you need an accommodation to apply for a job, email us at recruiting@gapsi.com . You will need to reference the requisition number of the position in which you are interested. Your message will be routed to the appropriate recruiter who will assist you. Please note, this email address is only to be used for those individuals who need an accommodation to apply for a job. Emails for any other reason or those that do not include a requisition number will not be returned.

Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, protected veteran status or other characteristics protected by law.

This position is contingent upon contract award.