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It System Analyst Jobs in Boston, MA (NOW HIRING)

Eyepoint

IT System and Validation Analyst

Watertown, MA · On-site

The IT System and Validation Analyst is responsible for QA oversight of the validation and compliance of GxP-regulated computerized systems ensuring they are implemented, maintained, and retired in ...

Huxley

IT Systems Analyst

Waltham, MA · On-site

Manage and develop the system to track and report on contractor performance. Most of our KPI ... Analytical Thinking: Ability to leverage and analyze data to identify critical information, develop ...

Manulife

IT Business Systems Analyst

Boston, MA

Analyze information, develop creative solutions, and recommend approaches aligned with business ... System Mapping: Collaborate with Engineering and Architecture teams to create detailed system maps ...

CivicMinds, Inc.

System Analyst

Sudbury, MA · On-site

System Analyst Location: Sudbury, MA Type: Full-time | On-site Position Overview: The System ... Bachelor's degree in Computer Science, Information Technology, Business Administration, or a ...

Shawmut

Senior HRIS Analyst- Workday

Boston, MA · On-site

$149K/yr

Responsibilities We are seeking a Senior HRIS Analyst to support and optimize our Workday platform ... Ability to collaborate effectively across HR, Payroll, Finance, IT, and external partners.

Shawmut

Senior HRIS Analyst- Workday

Boston, MA · On-site

$149K/yr

Responsibilities We are seeking a Senior HRIS Analyst to support and optimize our Workday platform ... Ability to collaborate effectively across HR, Payroll, Finance, IT, and external partners.

Shawmut

Senior HRIS Analyst- Workday

Boston, MA · On-site

$149K/yr

We are seeking a Senior HRIS Analyst to support and optimize our Workday platform across key ... Ability to collaborate effectively across HR, Payroll, Finance, IT, and external partners.

Brady Corporation

HRIS Analyst

Boston, MA · On-site

We are seeking a detail-oriented HRIS Analyst to join our HRIT team. This role serves as the ... technology suite. You will be responsible for resolving technical tickets, maintaining data ...

Booz Allen Hamilton

IT Systems Engineer

Lexington, MA · On-site

$87 - $198/hr

As an IT Systems Engineer on our team, you'll have the chance to shape the development and upgrades ... Experience performing analysis studies in a modeling and simulation environment * UML or SysML OMG ...

MIT Lincoln Laboratory

System Analyst

Lexington, MA · On-site

The Integrated Missile Defense Technology Group performs analysis and develops technology to defend ... Please visit our Benefits page for more information. As an employee of MIT, you can also take ...

MIT Lincoln Laboratory

System Analyst

Lexington, MA

The Integrated Missile Defense Technology Group performs analysis and develops technology to defend ... Please visit our Benefits page for more information. As an employee of MIT, you can also take ...

MIT Lincoln Laboratory

System Analyst

Lexington, MA · On-site

The Integrated Missile Defense Technology Group performs analysis and develops technology to defend ... Please visit our Benefits page for more information. As an employee of MIT, you can also take ...

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All JobsIt System Analyst JobsIt System Analyst Jobs in Boston, MA

It System Analyst information

See Boston, MA salary details

$45.1K

$97K

$153.2K

How much do it system analyst jobs pay per year?

As of Sep 4, 2026, the average yearly pay for it system analyst in Boston, MA is $97,011.00, according to ZipRecruiter salary data. Most workers in this role earn between $71,700.00 and $117,300.00 per year, depending on experience, location, and employer.

What does an IT system analyst do?

An IT System Analyst is responsible for evaluating and improving computer systems to help organizations operate more efficiently. They analyze current systems and procedures, identify areas for improvement, and design solutions to enhance productivity. Their duties often include gathering user requirements, working with developers, conducting tests, and providing support to staff. System Analysts act as a bridge between business needs and IT solutions, ensuring technology aligns with organizational goals.

What are the key skills and qualifications needed to thrive as an IT system analyst, and why are they important?

To thrive as an IT System Analyst, you need strong analytical abilities, problem-solving skills, and a degree in computer science or a related field. Familiarity with systems analysis tools, database management systems (DBMS), and proficiency in languages like SQL or Python are typically required, along with relevant certifications such as CompTIA or Microsoft Certified: Azure Fundamentals. Excellent communication, critical thinking, and collaboration skills help IT System Analysts translate technical requirements into effective solutions and work smoothly with stakeholders. These skills and qualifications are crucial for accurately evaluating business needs, designing optimal systems, and ensuring successful IT project implementation.

What are some common challenges IT system analysts face when balancing user requirements with technical constraints?

IT System Analysts often encounter the challenge of translating diverse user needs into feasible technical solutions within the limitations of existing systems and budgets. Balancing stakeholder expectations with what is technically possible requires strong communication and problem-solving skills. Analysts frequently need to negotiate compromises, prioritize features, and ensure that system enhancements align with organizational goals while maintaining security and performance standards.

What is the difference between It System Analyst vs Network Administrator?

AspectIt System AnalystNetwork Administrator
Primary RoleAnalyzes and designs IT systems to meet business needsManages and maintains computer networks and infrastructure
Required SkillsSystems analysis, project management, understanding of software and hardwareNetwork configuration, security, troubleshooting, hardware setup
CertificationsITIL, CompTIA Security+, Cisco CCNA (optional)CCNA, CompTIA Network+, Cisco CCNP
Work EnvironmentOffice settings, project teams, client interactionsData centers, server rooms, network operation centers

While both roles involve IT expertise, an It System Analyst focuses on designing and improving systems to support business goals, whereas a Network Administrator manages and maintains network infrastructure to ensure connectivity and security. Both roles often collaborate but serve different core functions within IT departments.

How much does an IT system analyst earn?

The average salary for an IT system analyst typically ranges from $60,000 to $100,000 annually, depending on experience, location, and industry. Entry-level analysts may earn less, while those with specialized skills or certifications can earn higher salaries.

How much does an IT system analyst make in the US?

An IT system analyst in the US typically earns a median annual salary of around $70,000 to $90,000, depending on experience, location, and certifications. Entry-level positions may start lower, while experienced analysts with specialized skills can earn over $100,000 annually.

What are popular job titles related to It System Analyst jobs in Boston, MA?

For It System Analyst jobs in Boston, MA, the most frequently searched job titles are:

What job categories do people searching It System Analyst jobs in Boston, MA look for?

The top searched job categories for It System Analyst jobs in Boston, MA are:

It System Analyst jobs near you
Infographic showing various It System Analyst job openings in Boston, MA as of August 2026, with employment types broken down into 1% As Needed, 83% Full Time, 13% Part Time, and 3% Contract. Highlights an 91% Physical, 2% Hybrid, and 7% Remote job distribution, with an average salary of $97,011 per year, or $46.6 per hour.

IT System and Validation Analyst

Eyepoint

Watertown, MA • On-site

Full-time

Posted 4 days ago

Key responsibilities

  • Collaborate with GxP system business owners to ensure validation processes and procedures are aligned with regulatory standards.

  • Provide validation oversight and lifecycle ownership for new and existing computerized systems, including upgrades, integrations, and decommissioning activities.

  • Author, review, and approve validation deliverables such as validation plans, requirements, risk assessments, test scripts, and validation reports.

Job description

The General & Administrative (G&A) functional teams at EyePoint include Finance and Accounting, Human Resources, Information Technology, Legal, and Compliance. This team ensures the company operates efficiently and effectively while maintaining high standards in the regulated environment (FDA, SEC, etc.) where we operate. In parallel, the G&A organization is an important partner as EyePoint advances therapeutics to improve the lives of patients with serious retinal diseases.
The IT System and Validation Analyst is responsible for QA oversight of the validation and compliance of GxP-regulated computerized systems ensuring they are implemented, maintained, and retired in accordance with global regulatory requirements, industry standards, and internal procedures.
Primary responsibilities include, but are not limited to, the following:
Individual Responsibilities
GxP Systems & Applications
  • Collaborate with GxP system business owners to ensure internal CSV processes and procedures are aligned to GAMP 5, 21 CFR Part 11, EU Annex 11, and FDA's Computer Software Assurance (CSA) guidance.
  • Serve as a subject matter expert (SME) providing qualification and validation expertise to CMC, Manufacturing Operations, Facilities, Quality Control, Quality Assurance, and Engineering departments.
  • Provide CSV oversight and lifecycle ownership for new computerized system implementations, upgrades, integrations, cloud/SaaS solutions, migrations, and decommissioning activities.
  • Author, review, and/or approve validation deliverables across the full CSV lifecycle, including but not limited to:
    • Validation Plans
    • User Requirements Specifications (URS) and Functional Specifications (FS)
    • Risk Assessments
    • Traceability Matrices
    • IQ/OQ/PQ Protocols and Test Scripts
    • Validation Summary Reports
    • Data Integrity, System Impact and Part 11 Assessments
    • Operating and Administrative Procedures
    • Periodic Review and System Retirement/Archival Plans
  • Categorize and maintain an inventory of GxP computerized systems using GAMP 5 system categories to support risk-based validation strategies.
  • Ensure validated systems remain in a state of control through change management, periodic review, requalification, deviation management, CAPA, etc.
  • Collaborate with internal stakeholders and business process owners to define validation strategies, risk-based approaches, and compliant delivery models aligned with GxP expectations.
  • Coordinate with vendors and managed service providers for maintenance, upgrades, supplier assessments, and issue resolution to minimize system downtime and ensure continued compliance.
  • Author, review, and maintain SOPs, work instructions, and templates related to computer system validation and data integrity.
  • Support regulatory inspections, internal audits, and external audits by providing validation documentation, system rationale, and SME responses as needed.
  • Identify and escalate data integrity risks and compliance gaps, recommending remediation strategies consistent with applicable regulatory guidance.
  • Provide exertise and mentoring to cross-functional team members on CSV concepts, regulatory expectations, and documentation standards.
  • Provide administrative ownership of released systems for activities such as creating users, supplier change notifications, basic issue resolution, etc
  • Ability to lead and coordinate cross-functional project teams - including IT, Quality, business process owners, and vendors - through validation activities, ensuring alignment on scope, timelines, and deliverables.

Primary skills and knowledge required include, but are not limited to the following:
  • Previous experience in Computer System Validation (CSV) within an FDA-regulated or GxP environment.
  • Strong working knowledge of GAMP 5, 21 CFR Part 11, and EU Annex 11 with the ability to apply risk-based validation strategies.
  • Experience validating GxP computerized systems across laboratory, manufacturing, quality and/or cloud-based environments.
  • Understanding of access control, security principles, audit trail requirements, and data integrity controls in regulated environments.
  • Ability to manage GxP system lifecycle activities including change control, deviations, CAPAs, periodic reviews, etc.
  • Strong documentation and technical writing skills with experience authoring validation plans, requirements, risk assessments, test protocols, summary reports, etc.
  • Effective communication and collaboration skills, with proven ability to interface between technical teams, vendors, and business stakeholders.
  • Strong analytical and problem-solving skills with the ability to troubleshoot complex system and compliance issues in a timely manner.
  • High attention to detail and commitment to data integrity and regulatory compliance.
  • Experience supporting audits, inspections, supplier assessments, or compliance remediation programs.

Level of Education Required:
Bachelor's degree in Engineering, Life Sciences, Computer Science, or a related technical discipline; master's degree a plus.
Number of Years of Experience in the Function and in the Industry:
Minimum 5-7 years of direct CSV experience within an FDA-regulated or GxP environment (pharmaceutical, biotechnology, medical device, or similar).
EyePoint is committed to fair and equitable compensation practices. The salary offer is commensurate with EyePoint's compensation philosophy and considers factors including but not limited to education, training, experience, market conditions, criticality of the role and internal equity.
The target salary range for this position is listed below:
Salary Range
$128,750-$163,083 USD
Envision Your Future
With the exciting energy of a winning culture and an exhilarating pace, we are an ophthalmology company committed to preventing blindness by developing and commercializing innovative therapeutics.
The collective power of our values influences everything we do, and everything we do for you.
Transformational Innovation
We exist to change our patients' lives through the power of sight. We are forward looking, embrace challenges with curiosity, and continuously seek to improve our products and ourselves by learning, problem-solving and pushing the limits of science and technology.
Unwavering Integrity
We recognize our responsibility to our patients, employees, and our community, and value the trust they put in us. We set a high ethical bar and expect responsible leadership at every level to ensure we serve those who matter most to us.
Compassionate Excellence
We believe that fun and excellence can coexist. We foster a culture where enjoying the work we do and caring for each other are as important as delivering exceptional outcomes.
Inclusive Collaboration
We strive to see through the eyes of others and work as one team. We appreciate one another's differences and perspectives, and ensure everyone feels valued, respected and encouraged to bring their ideas forward.
EyePoint is proud to be an equal opportunity employer. We believe that diversity and inclusion among our colleagues is critical to our success as a company, and we seek to recruit, develop, and retain the most talented people from a diverse candidate pool. All applicants will be considered for employment without attention to age, race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.

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