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Process Scientist

Philadelphia, PA · On-site

A Scientist is a mid-level individual with understanding of cell/molecular biology and previous experience in either upstream or downstream biopharmaceutical processing that utilizes bioreactors. A ...

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Infographic showing various Internship Upstream Process Scientist job openings in the United States as of June 2026, with employment types broken down into 50% Full Time, and 50% Contract. Highlights an 90% Physical, 1% Hybrid, and 9% Remote job distribution.
Upstream Senior Scientist, Process Development

Upstream Senior Scientist, Process Development

Wheeler Bio, Inc.

Oklahoma City, OK • On-site

$85K - $116K/yr

Full-time

Posted 16 days ago

Job description

As an upstream Process Development Senior Scientist, you will support the development, optimization, and scale-up of mammalian upstream bioprocesses for the manufacture of biologic drug substances. You will contribute to the design and execution of laboratory experiments, data analysis, and technical documentation.

Key Responsibilities:

· Perform laboratory experiments to support mammalian upstream (cell culture) process development.

· Utilize Design of Experiments (DoE) for data analysis and experimental design.

· Assist in the optimization of upstream bioprocess parameters for yield, purity, and product quality attributes, collaborating with downstream, analytical and formulation teams.

· Support scale-up and technology transfer of processes to manufacturing or pilot facilities based on engineering principles including oxygen transfer.

· Work cross-functionally with analytical development, MSAT, manufacturing and quality teams to drive successful technology transfer.

· Prepare buffers, media, and other solutions according to SOPs and protocols.

· Operate and maintain flask and bioreactor equipment.

· Collect, analyze, and interpret experimental data; maintain accurate lab records and electronic notebooks.

· Present findings in internal and client meetings.

· Author technical reports and regulatory documentation.

· Complete Root Cause Analyses as needed, implementing corrective and preventative actions as needed.

· Mentor junior scientists and research associates in daily activities, data trending and data analysis.

· Follow all safety, quality, and compliance requirements.

Qualifications:

Education:

· Bachelor's, master's or PhD degree in Chemical Engineering, Biochemistry, Biotechnology, Biology, or related field.

Experience:

· 5 - 12 years of hands-on experience in a bioprocessing or biopharmaceutical development environment (academic or industrial); some education qualifications may substitute for some years of experience.

· Experience in a CDMO environment is required.

· Experience with suspension mammalian cell culture and stirred tank bioreactors is required.

· Knowledge of protein purification and analytical techniques is a plus.

Skills and Knowledge:

· Understanding of cGMP, GLP, or other regulatory standards (preferred).

· Strong analytical and problem-solving skills.

· Good written and verbal communication skills.

· Ability to work both independently and in a collaborative team environment.