Internship Molecular Simulation Jobs (NOW HIRING)

Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best - people with the right technical expertise and a relentless drive to solve real problems - and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we've produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. SUMMARY: The BioMarin Summer Internship Program will enable students to gain valuable experience and knowledge of the processes and systems within BioMarin, while gaining an insight into the pharmaceutical/biotech industry. Over the course of 10 - 12 weeks our interns gain industry experience while working alongside our talented team on meaningful projects. Statistical Science, a function of BioMarin Data Science, provides statistical expertise and leadership in the design and execution of Phase 1-4 clinical trials. This includes the analysis, interpretation, and reporting of trial data to support clinical development, medical affairs, market access, and scientific publications across the lifecycle of therapeutic products. Statistical Science works closely with Clinical Science, Pharmacovigilance, Regulatory Affairs, Market Access, Medical Affairs, as well as Data Analytics Science and Data Management Science to achieve these objectives. JOB DESCRIPTION/PROJECT: The intern will:

• Work closely with senior members of the Statistical Science function on research and application of Bayesian mixed effect models for clinical data

• Explore approaches for historical data augmentation in trial settings

• Work on seamless Phase 2/3 design including sample size re-estimation and alpha adjustment, run simulation to assess statistical operating characteristics of a seamless design

• Have opportunities to gain hands-on experience in innovative statistical methodologies applied to real clinical study design and data analysis

Present project achievements to the Statistical Science function at the end of the summer Required Skills:

• Proficiency in SAS, and/or R, and/or Python

• Solid understanding of Bayesian methods and mixed-effects modelling

• Knowledge of historical data augmentation and adaptive or seamless trial design (sample size re-estimation, alpha adjustment)

• Strong ability to conduct methodological research, strong problem-solving skills

• Strong communicationskills and ability to work independently and collaboratively

Desired Skills:

• Strong knowledge of Bayesian methods, mixed effect models, and adaptive design

• Familiarity with sample size re-estimation and alpha adjustment preferred.

Qualifications/Eligibility:

• PhD candidate in Statistics, Biostatistics, or related field.

• Must be available to work full-time, 40 hours a week.

• Must be currently enrolled as a full-time student at an accredited U.S. based university or college and enrolled in the fall term after the completion of the internship OR have graduated within 1 year of the start of the program.

Benefits of a BioMarin Internship:

• Paid hourly wage, paid company holidays, and sick time

• Apply skills and knowledge learned in the classroom to on-the-job experiences

• Comprehensive, value-added project(s)

• Develop skills specific to your major.

• Opportunities for professional development by building relationships and learning about other parts of the business.

• Participate in company all hands meetings, monthly community lunches

• Corporate office amenities such as: 24/7 on-site gym, coffee truck, snacks

• Access to Employee Resource Groups

Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned.
Equal Opportunity Employer/Veterans/Disabled
An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. In the U.S., the salary range for this position is $32 to $50 per hour, which factors in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors.