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Job Title: Protein Expression & Purification Scientist Location: Alameda, CA Type: 12 month contract Compensation: $50-55/hour depending on qualifications Contractor Work Model: Onsite Hours: 40 hours/week

Overview

We are seeking a Protein Expression & Purification Scientist to support drug discovery programs through the design, expression, purification, and characterization of recombinant proteins. This hands-on laboratory role requires expertise in molecular biology, protein expression systems, and chromatographic purification methods, with opportunities to contribute across multiple research initiatives in a fast-paced discovery environment.

Responsibilities

• Design, clone, and optimize expression constructs using molecular biology techniques, including PCR, primer design, sequence verification, and recombinant cloning strategies.
• Execute recombinant protein expression workflows using baculovirus expression vector systems (BEVS) in insect cells and E. coli expression platforms.
• Generate, amplify, and optimize baculovirus stocks to support protein production objectives.
• Perform high-throughput small-scale expression screening to evaluate constructs, expression conditions, and protein yield.
• Purify recombinant proteins using affinity, ion exchange, and size-exclusion chromatography techniques.
• Optimize expression, culture, and purification parameters to improve protein yield, purity, and overall quality.
• Conduct analytical characterization using SDS-PAGE, Western blotting, SEC, and related protein analysis methods.
• Document experimental procedures, results, and observations in accordance with laboratory documentation standards.
• Analyze data, troubleshoot technical challenges, and recommend improvements to workflows and experimental strategies.
• Communicate scientific findings and project updates effectively with cross-functional team members.

Requirements

Required Qualifications

• Bachelor's degree in Biochemistry, Molecular Biology, Structural Biology, or a related scientific discipline with 3+ years of relevant industry experience; or Master's degree with 1+ year of relevant industry experience.
• Strong expertise in molecular biology techniques, including cloning, vector design, construct optimization, and sequence verification.
• Experience with PCR, primer design, restriction enzyme-based cloning, and recombination-based cloning methods.
• Demonstrated experience expressing recombinant proteins in BEVS/insect cell systems and E. coli expression systems.
• Experience with high-throughput small-scale protein expression screening.
• Proficiency in protein purification using chromatographic techniques, including affinity, ion exchange, and size-exclusion chromatography.
• Experience performing protein analytical characterization using SDS-PAGE, Western blotting, SEC, and related techniques.
• Strong analytical, troubleshooting, and problem-solving skills.
• Ability to independently manage experiments while collaborating effectively within multidisciplinary teams.
• Strong organizational, documentation, and scientific communication skills.

Preferred Qualifications

• Experience with biophysical characterization techniques such as LC-MS, SPR, MST, SEC-MALS, nanoDSF, or mass photometry.
• Experience with protein purification method development and process optimization.
• Familiarity with electronic laboratory notebooks, including Benchling.
• Experience supporting protein production activities within a drug discovery or biopharmaceutical research environment.

Benefits

System One, and its subsidiaries including Joulé, ALTA IT Services, and Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.

System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.