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Hplc Chromatography Jobs (NOW HIRING)

Weil Group, Inc.

Chemist

Dorado, PR · On-site

Technical Skills • Chromatography • Empower software • HPLC operation and troubleshooting • UV spectroscopy • IR spectroscopy • Analytical testing • USP and EP standards • Laboratory ...

Inteldot

Chemist

Dorado, PR · On-site

Operate, maintain, and troubleshoot analytical laboratory equipment, including HPLC, UV, IR, and related instrumentation. * Execute analytical methods and interpret test results. * Use chromatography ...

Validation & Engineering Group, Inc.

Chemist

Dorado, PR · On-site

Operate, maintain, and troubleshoot analytical laboratory equipment, including HPLC, UV, IR, and related instrumentation. * Execute analytical methods and interpret test results. * Use chromatography ...

Technical & Engineering Consulting

Chemist

Dorado, PR · On-site

HPLC * UV Spectrophotometry * IR Spectrophotometry * Other analytical laboratory equipment * Working knowledge of chromatography principles and analytical techniques. * Experience using Empower ...

Veg Group

Chemist

Dorado, PR · On-site

Operate, maintain, and troubleshoot analytical laboratory equipment, including HPLC, UV, IR, and related instrumentation. * Execute analytical methods and interpret test results. * Use chromatography ...

Pinnaql

Chemist

Dorado, PR · On-site

Operate, maintain, and troubleshoot analytical laboratory equipment, including HPLC, UV, IR, and related instrumentation. * Execute analytical methods and interpret test results. * Use chromatography ...

System One

Sr Research Associate I

San Rafael, CA · On-site

$39 - $42.93/hr

Hands-on experience operating ÄKTA Pure, ÄKTA Avant, or equivalent FPLC chromatography systems. * Experience with protein analytical techniques including SEC-HPLC, RP-HPLC, CE-SDS, SDS-PAGE, and UV ...

System One

Sr Research Associate I

San Rafael, CA · On-site

$39 - $42.93/hr

Hands-on experience operating ÄKTA Pure, ÄKTA Avant, or equivalent FPLC chromatography systems. * Experience with protein analytical techniques including SEC-HPLC, RP-HPLC, CE-SDS, SDS-PAGE, and UV ...

System One

Sr Research Associate I

San Rafael, CA · On-site

$39 - $42.93/hr

Hands-on experience operating ÄKTA Pure, ÄKTA Avant, or equivalent FPLC chromatography systems. * Experience with protein analytical techniques including SEC-HPLC, RP-HPLC, CE-SDS, SDS-PAGE, and UV ...

System One

Sr Research Associate I

San Rafael, CA · On-site

$39 - $42.93/hr

Hands-on experience operating ÄKTA Pure, ÄKTA Avant, or equivalent FPLC chromatography systems. * Experience with protein analytical techniques including SEC-HPLC, RP-HPLC, CE-SDS, SDS-PAGE, and UV ...

System One

Sr Research Associate I

San Rafael, CA · On-site

$39 - $42.93/hr

Hands-on experience operating ÄKTA Pure, ÄKTA Avant, or equivalent FPLC chromatography systems. * Experience with protein analytical techniques including SEC-HPLC, RP-HPLC, CE-SDS, SDS-PAGE, and UV ...

System One

Sr Research Associate I

San Rafael, CA · On-site

$39 - $42.93/hr

Hands-on experience operating ÄKTA Pure, ÄKTA Avant, or equivalent FPLC chromatography systems. * Experience with protein analytical techniques including SEC-HPLC, RP-HPLC, CE-SDS, SDS-PAGE, and UV ...

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How much do hplc chromatography jobs pay per hour?

As of Sep 15, 2026, the average hourly pay for hplc chromatography in the United States is $42.08, according to ZipRecruiter salary data. Most workers in this role earn between $31.49 and $48.56 per hour, depending on experience, location, and employer.

What is HPLC chromatography?

HPLC chromatography, or High-Performance Liquid Chromatography, is an analytical technique used to separate, identify, and quantify components in a mixture. It works by passing a liquid sample through a column packed with a solid adsorbent material, where different substances in the sample move at different rates. This method is widely used in pharmaceutical, environmental, food, and chemical laboratories for quality control, research, and analysis of complex mixtures. HPLC offers high resolution, sensitivity, and accuracy, making it a valuable tool for detecting trace levels of substances in various samples.

What are the key skills and qualifications needed to thrive as an HPLC chromatography specialist?

To excel as an HPLC Chromatography Specialist, you need a strong background in analytical chemistry, laboratory techniques, and a relevant science degree. Familiarity with HPLC instrumentation, data analysis software (such as Empower or ChemStation), and knowledge of Good Laboratory Practice (GLP) standards are essential. Attention to detail, problem-solving abilities, and effective communication skills are crucial for accurate analysis and collaboration within lab teams. These competencies ensure precise, reliable results and maintain the integrity and efficiency of laboratory operations.

What are some typical challenges faced by HPLC chromatography specialists, and how can they be addressed?

HPLC Chromatography specialists often encounter challenges such as sample preparation inconsistencies, method development complexities, and instrument maintenance issues. Addressing these requires thorough training in method validation, regular calibration of instruments, and adherence to strict laboratory protocols. Collaboration with analytical chemists and quality assurance teams also helps in troubleshooting and ensuring data accuracy. Staying updated with new techniques and technologies in chromatography can further enhance efficiency and problem-solving.

What is the difference between Hplc Chromatography vs Laboratory Technician?

AspectHplc ChromatographyLaboratory Technician
CredentialsDegree in Chemistry, Biochemistry, or related field; training in chromatography techniquesAssociate's or Bachelor's in Science; general lab training
Work EnvironmentAnalytical labs, pharmaceutical, biotech, or research facilitiesVaried labs including clinical, environmental, or industrial settings
Job FocusDeveloping, operating, and troubleshooting HPLC systems for analysisPerforming routine lab tests, sample preparation, and data recording

Hplc Chromatography specialists focus on operating and maintaining HPLC systems for precise chemical analysis, requiring specialized training. Laboratory Technicians perform broader lab tasks, often including sample handling and basic testing. Both roles are essential in lab environments but differ in technical depth and responsibilities.

What does a HPLC chromatography analyst do?

A HPLC chromatography analyst operates and maintains high-performance liquid chromatography (HPLC) systems to analyze chemical samples. They prepare samples, run tests, interpret data, and ensure quality control in laboratory environments, often following standard operating procedures and safety protocols.
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Infographic showing various Hplc Chromatography job openings in the United States as of September 2026, with employment types broken down into 90% Full Time, 2% Part Time, 6% Contract, and 2% Nights. Highlights an 93% Physical, 1% Hybrid, and 6% Remote job distribution, with an average salary of $87,519 per year, or $42.1 per hour.

Process Chemistry Principal Scientist

Boston, MA • On-site

Vertex Pharmaceuticals
Biotechnology Research and Development • 1 - 5K employees
Learn more about Vertex Pharmaceuticalsexternal

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 4 days ago

Vertex Pharmaceuticals rating

6.5

Company rating: 6.5 out of 10

Based on 5 frontline employees who took The Breakroom Quiz

Job description

Job Description
General Summary:
Vertex Pharmaceuticals is seeking a highly experienced and motivated Principal Scientist to join the Vertex Manufacturing Center (VMC) Kilo Lab in a dual-capability role that is central to our drug substance development mission. This is an exceptional opportunity for a seasoned pharmaceutical scientist with deep expertise in analytical and preparative chromatographic purification in both an R&D and cGMP environment- including large-scale preparative HPLC, supercritical fluid chromatography (SFC), Ion-pair reversed phase high-performance liquid chromatography (IP-RP_HPLC), ion exchange chromatography (AEX/CEX), and size exclusion chromatography (SEC). This individual will play a pivotal role in jumpstarting Vertex's emerging kilo-scale cGMP purification capabilities and laboratory, contributing also to new therapeutic modalities with significant pipeline impact.
Key Duties and Responsibilities:
  • Lead Preparative Chromatography Method Development Spearhead the development, optimization, and scale-up of preparative HPLC and SFC purification methods across all scales - from semi-preparative to kilogram for both R&D and cGMP- selecting appropriate chromatographic modes (RP, NP, IEX, SEC) based on compound class and impurity profile
  • Execute & Troubleshoot Complex Purification Campaigns Lead hands-on execution of mass-directed and preparative purification campaigns for complex small molecule drug substances, troubleshooting challenging separations and developing creative, scientifically sound solutions
  • Establish & Maintain Lab Infrastructure: Drive equipment procurement, column packing, system qualification, and ongoing maintenance of large-scale chromatography platforms; influence technology selection and lab infrastructure investments to build a world-class separations capability
  • Perform Kilo-Lab Scale Synthesis: Ability to flex into multi-step synthesis of drug substance intermediates and APIs at gram-to-kilogram scale, including reactions in jacketed vessels and large-scale reactor systems, with full accountability for safety, quality, and yield
  • Support Scale-Up & Process Chemistry Collaboration: Partner with Process Chemistry, Analytical DevelopmentD and project teams to implement and adapt synthetic routes for kilo-lab operations, performing workups, crystallizations, filtrations, and drying at scale, and interpreting analytical data (NMR, HPLC, MS) to drive process decisions
  • Build Peptide and Oligonucleotide Purification Capability: Define the strategic roadmap and lead the implementation of kilogram oligonucleotide synthesis (solid-phase phosphoramidite chemistry) and purification platforms (IP-RP HPLC, AEX/CEX, ultrafiltration/diafiltration), including equipment procurement, qualification, and SOP establishment
  • Mentor & Develop Scientific Staff: Provide hands-on mentorship, technical coaching, and structured training to junior scientists, associates, and technicians - equipping them to independently master preparative chromatography, separations techniques, and kilo-lab operations
  • Author & Own GMP Documentation: Author, review, and approve SOPs, master batch records, validation protocols, purification reports, and technical documents in full compliance with cGMP standards and Vertex quality systems
  • Lead Cross-Functional Technical Initiatives: Serve as the organizational SME for preparative purification and drug substance chemistry; lead cross-functional project teams and act as primary technical liaison with Analytical Development, Process Chemistry, Quality, and Manufacturing groups
  • Ensure GMP Compliance, Quality & Safety: Ensure all lab operations adhere strictly to cGMP regulations, EHS standards, and Vertex quality requirements; maintain meticulous documentation (ELN, batch records, deviations, change controls) and support internal/external audits as a subject matter expert

Knowledge and Skills:
  • Expert-level proficiency in preparative chromatography (HPLC, SFC, IP-RP, AEX, CEX SMB, and SEC) across all scales, encompassing method development, column selection, mobile phase optimization, mass-directed purification systems, and chromatography data systems (e.g., Empower, OpenLab)
  • Demonstrated track record of technical leadership and cross-functional collaboration, with the ability to influence stakeholders, lead project teams, and drive scientific decisions without direct authority.
  • Strong written and verbal communication skills, with proven ability to present complex technical findings to diverse audiences ranging from bench scientists to senior leadership
  • Experience mentoring and developing junior scientists and technical staff, fostering growth in separations techniques and kilo-lab operations
  • Deep working knowledge of cGMP regulations, documentation standards, and quality systems as applied to drug substance manufacturing, including authoring and reviewing batch records, SOPs, deviation reports, and validation protocols
  • Demonstrated commitment to laboratory safety, environmental health standards, and maintaining a culture of quality and compliance across all operations
  • Ability to flex into hands-on synthetic organic chemistry at kilogram scale, including jacketed reactor operations, large-scale workups, and the ability to interpret complex analytical data (HPLC, LC-MS, NMR, Karl Fischer) to drive purification and synthetic decisions

Education and Experience:
  • Ph.D. in Analytical Chemistry, Organic Chemistry, Medicinal Chemistry, Chemical Engineering, or a closely related discipline preferred; M.S. or B.S. with extensive relevant industry experience will be considered.
  • Bachelor's degree and 10+ years, Master's degree and 7+ years, or PhD and 4+ years of hands-on industry experience in R&D and cGMP pharmaceutical analytical and preparative separations, drug substance development manufacturing or the equivalent combination of education and experience

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pay Range:
$138,000 - $207,000
Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
On-Site Designated
Flex Eligibility Status:
In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.
#LI-Onsite
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

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