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How much do high throughput screening scientist jobs pay per year?

As of Jul 27, 2026, the average yearly pay for high throughput screening scientist in the United States is $122,738.00, according to ZipRecruiter salary data. Most workers in this role earn between $98,500.00 and $136,000.00 per year, depending on experience, location, and employer.

What does a typical day look like for a High Throughput Screening Scientist?

A typical day for a High Throughput Screening Scientist involves designing, executing, and analyzing high-volume biological assays to test large libraries of compounds. Scientists often split their time between the laboratory—operating robotic liquid handlers and automated screening equipment—and the office, where they interpret data and prepare reports. Collaboration is a key part of the role, as these scientists work closely with chemists, data analysts, and project managers to drive drug discovery projects forward. The work is fast-paced and dynamic, offering variety and the opportunity to contribute to groundbreaking scientific advancements.

What are the key skills and qualifications needed to thrive in the High Throughput Screening Scientist position, and why are they important?

To thrive as a High Throughput Screening Scientist, you generally need a background in biochemistry, molecular biology, or a related field, with experience in assay development and compound screening. Familiarity with lab automation platforms, liquid handling robotics, and data analysis software such as Spotfire or Pipeline Pilot is highly valued. Strong attention to detail, analytical thinking, and effective teamwork and communication skills help scientists excel in this collaborative environment. These capabilities are important to ensure precise, efficient experimentation, high data quality, and successful integration with larger research and development projects.

What does a High Throughput Screening Scientist do?

A High Throughput Screening (HTS) Scientist designs, optimizes, and executes automated experiments to rapidly test thousands of chemical or biological compounds for potential activity in drug discovery or research. They develop and validate assays, operate robotic instrumentation, analyze large datasets, and collaborate with interdisciplinary teams to identify promising candidates for further study. Their work is essential in accelerating drug discovery, reducing costs, and improving efficiency in identifying potential therapeutic compounds.

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High Throughput Screening Scientist jobs near you
Infographic showing various High Throughput Screening Scientist job openings in the United States as of July 2026, with employment types broken down into 1% As Needed, 81% Full Time, 16% Part Time, and 2% Contract. Highlights an 95% Physical, 1% Hybrid, and 4% Remote job distribution, with an average salary of $122,738 per year, or $59 per hour.
Scientist - High-Throughput Screening & Analytical Chemistry

Scientist - High-Throughput Screening & Analytical Chemistry

Manus Bio

Waltham, MA • On-site

Full-time

Posted 7 days ago

Job description

Scientist - High-Throughput Screening & Analytical Chemistry - Waltham, MA, Full-time
Manus works across industries and value chains to accelerate the transition to BioAlternatives - better performing and more sustainable versions of complex molecules traditionally sourced from plants, animals, or fossil fuels. Our platform is proven to work across scales, bridging the Valley of Death between lab and manufacturing more efficiently and more reliably to deliver the benefits of biotechnology today.
We are seeking a Scientist in Screening & Analytical Chemistry to lead development of high-throughput analytical workflows. This role focuses on method development for rapid, targeted metabolite quantification and integration with screening pipelines.
This hands-on position requires a desire and ability to work as an integral part of a multidisciplinary team, as well as the demonstration of a high degree of flexibility, creativity, and initiative. This person will be expected to play an integral part of Manus's research and development team located in Waltham, MA.
Why work at Manus:
  • Opportunity - For motivated, results-oriented team members, our growth creates opportunities for personal and professional advancement.
  • Accountability - You are given the resources you need to succeed and the freedom to make it happen; in return, we hold each other accountable for our high expectations.
  • Passion - We love what we do and enjoy working with others who feel the same way. We embrace the challenge and hard work that comes with working on the cutting edge.

Responsibilities
  • Develop and optimize analytical methods for targeted metabolite quantification
  • Lead method development on GC/MS, GC-FID, and LC-QQQ-MS platforms
  • Design high-throughput analytical workflows with fast cycle times
  • Develop sample preparation and derivatization strategies
  • Work with automation and screening teams to support microtiter plate-based fermentations
  • Analyze and interpret large datasets
  • Mentor junior staff
  • Interface with instrument vendors to maintain uptime and optimal performance
  • Author SOPs and technical reports

Basic Qualifications
  • PhD in Analytical Chemistry, Chemistry, or related field OR
  • MS with 8+ years or BS with 13+ years relevant experience
  • Strong experience in analytical method development

Required Technical Expertise
  • GC-FID and GC/MS assay development for targeted quantitation and metabolite profiling
  • LC/QQQ-MS assay develop for targeted quantitation
  • Assay optimization for speed, sensitivity, and throughput

Preferred Experience
  • Experience with high-throughput screening environments
  • Integration of analytical workflows with automation
  • Familiarity with liquid handling platforms
  • Experience with LIMS (e.g. Benching) and large datasets
  • Industrial biotech or applied R&D experience
  • Experience with the following types of analytical instrumentation
    • UHPLC
    • GC-FID
    • GC/MS
    • LC/QQQ-MS
  • Experience with a variety of sample extraction and preparation techniques, applying automated solutions when appropriate, from complex matrices
    • Microbial fermentation broth
    • Microbial biomass
    • Purified extracts

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