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$122.7K

$196.5K

How much do contract high throughput screening scientist jobs pay per year?

As of Jul 27, 2026, the average yearly pay for contract high throughput screening scientist in the United States is $122,738.00, according to ZipRecruiter salary data. Most workers in this role earn between $98,500.00 and $136,000.00 per year, depending on experience, location, and employer.

What does a Contract High Throughput Screening Scientist do?

A Contract High Throughput Screening (HTS) Scientist is responsible for designing, executing, and analyzing large-scale biological or chemical screening experiments, typically in a pharmaceutical or biotech setting. They use automated technologies to rapidly test thousands of compounds against specific biological targets to identify potential candidates for drug development or research. As a contract scientist, they are usually hired for a specific project or time period, which can involve assay development, data analysis, and reporting findings to project teams. Their work is crucial for accelerating the discovery process and enabling informed decision-making in early-stage drug discovery.

What are the key skills and qualifications needed to thrive as a Contract High Throughput Screening Scientist, and why are they important?

To thrive as a Contract High Throughput Screening Scientist, you need a solid background in biology, chemistry, or related sciences, often supported by an advanced degree and experience with assay development. Familiarity with automated liquid handling systems, laboratory information management systems (LIMS), and data analysis software is typically required. Strong problem-solving abilities, attention to detail, and effective communication are important soft skills for this role. These competencies ensure high-quality experimental results, efficient workflow, and clear collaboration in fast-paced research environments.

What is the difference between Contract High Throughput Screening Scientist vs Contract Bioassay Scientist?

AspectContract High Throughput Screening ScientistContract Bioassay Scientist
CredentialsBachelor's or Master's in Life Sciences, Chemistry, or related field; experience with screening platformsBachelor's or Master's in Biology, Biochemistry, or related; experience with bioassay development
Work EnvironmentLaboratories focused on compound screening, automation, and assay testingLaboratories conducting biological activity testing, assay optimization, and validation
Employer & Industry UsagePharmaceutical and biotech companies, CROs involved in drug discoveryPharmaceutical, biotech, and CROs focusing on biological assay development

The Contract High Throughput Screening Scientist primarily focuses on testing large compound libraries using automated screening platforms, while the Contract Bioassay Scientist specializes in developing and validating biological assays. Both roles require laboratory experience in life sciences and are common in drug discovery settings, but they differ in their specific focus areas within the research process.

What are some common challenges faced by Contract High Throughput Screening Scientists, and how can they be addressed?

Contract High Throughput Screening Scientists often work in fast-paced environments where they must efficiently manage large volumes of samples and data within tight deadlines. One common challenge is ensuring data accuracy and reproducibility while handling automated instrumentation and complex assay protocols. Effective communication with cross-functional teams, including medicinal chemists and data analysts, is crucial for troubleshooting and optimizing screening processes. Familiarity with laboratory automation and strong organizational skills can help scientists navigate these challenges and contribute successfully to drug discovery projects.
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Contract High Throughput Screening Scientist jobs near you
Scientist - High-Throughput Screening & Analytical Chemistry

Scientist - High-Throughput Screening & Analytical Chemistry

Manus Bio

Waltham, MA • On-site

Full-time

Posted 7 days ago

Job description

Scientist - High-Throughput Screening & Analytical Chemistry - Waltham, MA, Full-time
Manus works across industries and value chains to accelerate the transition to BioAlternatives - better performing and more sustainable versions of complex molecules traditionally sourced from plants, animals, or fossil fuels. Our platform is proven to work across scales, bridging the Valley of Death between lab and manufacturing more efficiently and more reliably to deliver the benefits of biotechnology today.
We are seeking a Scientist in Screening & Analytical Chemistry to lead development of high-throughput analytical workflows. This role focuses on method development for rapid, targeted metabolite quantification and integration with screening pipelines.
This hands-on position requires a desire and ability to work as an integral part of a multidisciplinary team, as well as the demonstration of a high degree of flexibility, creativity, and initiative. This person will be expected to play an integral part of Manus's research and development team located in Waltham, MA.
Why work at Manus:
  • Opportunity - For motivated, results-oriented team members, our growth creates opportunities for personal and professional advancement.
  • Accountability - You are given the resources you need to succeed and the freedom to make it happen; in return, we hold each other accountable for our high expectations.
  • Passion - We love what we do and enjoy working with others who feel the same way. We embrace the challenge and hard work that comes with working on the cutting edge.

Responsibilities
  • Develop and optimize analytical methods for targeted metabolite quantification
  • Lead method development on GC/MS, GC-FID, and LC-QQQ-MS platforms
  • Design high-throughput analytical workflows with fast cycle times
  • Develop sample preparation and derivatization strategies
  • Work with automation and screening teams to support microtiter plate-based fermentations
  • Analyze and interpret large datasets
  • Mentor junior staff
  • Interface with instrument vendors to maintain uptime and optimal performance
  • Author SOPs and technical reports

Basic Qualifications
  • PhD in Analytical Chemistry, Chemistry, or related field OR
  • MS with 8+ years or BS with 13+ years relevant experience
  • Strong experience in analytical method development

Required Technical Expertise
  • GC-FID and GC/MS assay development for targeted quantitation and metabolite profiling
  • LC/QQQ-MS assay develop for targeted quantitation
  • Assay optimization for speed, sensitivity, and throughput

Preferred Experience
  • Experience with high-throughput screening environments
  • Integration of analytical workflows with automation
  • Familiarity with liquid handling platforms
  • Experience with LIMS (e.g. Benching) and large datasets
  • Industrial biotech or applied R&D experience
  • Experience with the following types of analytical instrumentation
    • UHPLC
    • GC-FID
    • GC/MS
    • LC/QQQ-MS
  • Experience with a variety of sample extraction and preparation techniques, applying automated solutions when appropriate, from complex matrices
    • Microbial fermentation broth
    • Microbial biomass
    • Purified extracts

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