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Head Statistical Programming Jobs (NOW HIRING)

OSI

$175K - $220K/yr

Associate Director, Statistical Programming The Associate Director, Statistical Programming will work in collaboration with the Head of Biometrics and leadership to provide strong programming support ...

Life Sciences WA

Global Head of Biostatistics

Charleston, SC · On-site

$210K - $290K/yr

The Head of Biostatistics is a senior executive leader responsible for defining and executing the ... While not expected to be hands‑on in SAP development, TLF production, statistical programming, or ...

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How much do head statistical programming jobs pay per year?

As of Sep 14, 2026, the average yearly pay for head statistical programming in the United States is $280,147.00, according to ZipRecruiter salary data. Most workers in this role earn between $260,500.00 and $322,500.00 per year, depending on experience, location, and employer.

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Infographic showing various Head Statistical Programming job openings in the United States as of July 2026, with employment types broken down into 1% As Needed, 81% Full Time, 15% Part Time, 1% Temporary, 1% Contract, and 1% Nights. Highlights an 95% Physical, 2% Hybrid, and 3% Remote job distribution, with an average salary of $280,147 per year, or $134.7 per hour.

Senior Manager, Statistical Programming

Princeton, NJ • On-site

Kardigan
See more jobs at Kardiganexternal

Full-time

Re-posted 19 days ago

Job description

About Us
Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.
It is Kardigan's mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve.
Led by Tassos Gianakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan's co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.
We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients.
At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families, we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in being authentic-leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn, we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries.
These values are the foundation of our work, empowering us to make a real difference, every day.
Position Title: Senior Manager, Statistical Programming
Department: Clinical Data Sciences & Analytics
Reports To: Head of Statistical Programming
Location: South San Francisco, CA or Princeton, NJ - On-site 4 days per week (Mon to Thurs)
Job Overview:
The Senior Manager of Statistical Programming will be responsible for leading Statistical Programming activities. It involves hands-on implementation of statistical analyses using SAS/R, as well as performing quality reviews of deliverables, both for in-house analyses and outsourced programming tasks.
This position serves as a critical bridge between Biostatistics and Clinical Data Management (CDM), ensuring the development of CRFs and the delivery of high-quality clinical data. Additionally, this position will play an important role in establishing SOPs and programming standards and modernizing statistical reporting with open-source tools.
ESSENTIAL DUTIES AND RESPONSIBILITIES
Key Project Responsibilities:
  • Provide programming leadership and oversee study to compound-level programming deliverables in collaboration with the lead biostatistician and cross-functional teams.
  • Serve as the lead programmer to review the SAP, Data Presentation Plan, and Table Shells to align with project objectives and ensure clarity and completeness of programming assumptions and requirements.
  • Lead programming team to produce and/or validate SDTM, ADaM, and TLF for CSR and regulatory requests, publication needs, and ad-hoc analyses.
  • Manage CROs and contractors, ensuring compliance, quality of deliverables, timelines, and budget adherence.
  • Collaborate with biostatisticians and clinical development colleagues to develop/review TLF shells, SDTM, and ADaM specifications.
  • Work closely with Data Management and Biostatistics teams to ensure the accuracy of final databases, analyses, and reports.
  • Develop company tools, such as R packages, macros, and interactive data dashboards (e.g., with Shiny), to enhance the efficiency and capacity of the Statistical Programming team.
  • Develop robust programs to create define.xml. Lead the NDA eSubmission package preparation.

Initiative Responsibilities:
  • Under the guidance of the Head of Statistical Programming and Compound Lead, implement innovative strategies and technologies to enhance programming processes.
  • Working with the manager, establish Statistical Programming standards and deploy programming strategies, specifications, and programmed analyses.
  • Proactively plan, implement, and identify issues/risks and provide remediation strategies to improve programming capability.

Qualifications and Preferred Skills
Education:
  • Master's degree in Statistics/Biostatistics, Mathematics, Computer Science, or a related field.

Experience and Skill Set:
  • Minimum of 6 years of statistical programming experience in the pharmaceutical, biotech, or CRO clinical trial environment.
  • Advanced SAS and R programming skills, with experience using Git for version control required. Extensive hands-on experience with SDTM, ADaM, and TLF programming.
  • Python programming experience is desirable.
  • Proficient knowledge in the implementation of CDISC standards (SDTM, ADaM) and regulatory submission requirements.
  • Good knowledge of the drug development process, study design, statistical methodology, regulatory guidance, statistical concepts, and medical terminology.
  • Broad expertise in statistical programming and in developing computing strategies.
  • In-depth understanding of CDISC standards including SDTM and ADaM models and extensive experience with their implementation in clinical trials.
  • Knowledge of data validation, define.xml generation using Pinnacle 21.
  • Results-oriented, with proven problem-solving skills and a strong interest in continued learning.
  • Excellent communication and collaboration skills, with the ability to work closely with cross-functional teams.
  • Experience managing outsourced programming activities and overseeing deliverables from CROs and contractors.
  • Adaptable and able to thrive in a fast-paced, startup environment while managing multiple priorities effectively.
  • Experience with regulatory audits and inspections (e.g., FDA, PMDA, NMPA, EMA) is a strong advantage.

Exact Compensation may vary based on skills, experience and location.
Pay range
$172,000-$234,000 USD

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