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Job Description

Principal Engineer, VaiDA User Experience

Location: Hybrid / On-site

Vertex Pharmaceuticals is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. At Vertex, we combine cutting-edge science, technology, and human-centered thinking to solve complex challenges and improve lives. Our digital and AI initiatives help empower employees across the organization with scalable, intuitive tools that accelerate innovation and decision-making.

Vertex Pharmaceuticals is seeking a Principal User Experience Engineer to shape the future of VaiDA, our enterprise AI platform for employees across Vertex. This role will design and build polished, seamless interfaces for sophisticated AI and multi-agent workflows used by employees across Vertex. The ideal candidate blends strong frontend engineering expertise with exceptional UX and product instincts, translating complex backend capabilities into user experiences that are clear, intuitive, and scalable for 10,000+ employees.

This is a foundational role focused on ensuring VaiDA is not only powerful, but also approachable, efficient, and trusted to use.

Design and build high-quality frontend experiences for VaiDA and related AI-driven enterprise workflows

Lead UX engineering strategy and frontend architecture for VaiDA

Own interaction design and prototyping for a wide spectrum of user journeys and multi-agent experiences

Translate sophisticated technical capabilities into clear, intuitive, and scalable interfaces

Create workflow visualizations that improve usability, clarity, and user confidence

Partner closely with product, engineering, AI, and business stakeholders to define user-centered solutions

Develop and refine reusable UI patterns, components, and design standards for enterprise-scale applications

Prototype and validate concepts quickly to inform product direction and implementation

Advocate for usability best practices and help raise the bar for design quality across digital products

Contribute to the overall product vision for VaiDA as a trusted and engaging enterprise AI experience

Mentor engineers and influence UX engineering best practices across teams

Required Qualifications

Bachelor's degree in Computer Science, Human-Computer Interaction, Design, Engineering, or a related field; or equivalent practical experience

Proven experience in frontend engineering, product design engineering, or UX engineering roles

Strong track record of designing and building polished, user-centered interfaces for complex applications

Experience translating technical or data-rich workflows into clear and intuitive user experiences

Demonstrated ability to own interaction design and prototyping from concept through implementation

Strong understanding of usability, accessibility, and responsive design principles

Experience collaborating cross-functionally with product managers, engineers, and stakeholders

Ability to balance user needs, technical constraints, and business goals in a fast-paced environment

Excellent communication, problem-solving, and presentation skills

Modern frontend development frameworks such as React, Angular, TypeScript, JavaScript, HTML, and CSS

Interaction design and frontend prototyping

Enterprise UI development and scalable design systems

Experience with design tools such as Figma or similar prototyping platforms

Workflow visualization and complex interface design

Usability and human-centered design practices

Frontend performance optimization

Component-based architecture and reusable UI patterns

Collaboration with backend and AI/agent-based systems

Accessibility standards and inclusive design implementation

Experience designing for AI-powered products, conversational interfaces, or multi-agent systems

Experience leveraging AI-assisted tools to accelerate frontend prototyping, design exploration, or development workflows

Familiarity with enterprise software and internal platform experiences

Understanding of product strategy and user research methods

Experience building interfaces for data-heavy, workflow-oriented, or highly technical applications

Familiarity with design systems governance and frontend architecture at scale

Vertex offers a competitive and comprehensive rewards package designed to support employees professionally and personally, which may include:

Competitive salary and performance-based incentives

Comprehensive health, dental, and vision coverage

Retirement and savings programs

Paid time off and company holidays

Professional development and career growth opportunities

Inclusive and collaborative work environment

Employee wellness and support programs

The opportunity to help shape innovative AI experiences that make a meaningful impact across Vertex

#LI-HYBRID

Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com