Downstream Jobs in Missouri (NOW HIRING)

Job Title: Downstream Processing Technician

Job Description

The Downstream Processing Technician III plays a key role in large-scale biological and chemistry pharmaceutical operations, supporting the manufacture of biologics such as proteins used in pharmaceutical products for conditions like autoimmune diseases. This position focuses on the flawless execution of manufacturing batch records, work instructions, and standard operating procedures (SOPs) in a cGMP-regulated, cleanroom environment. The role requires strong attention to detail, proactive problem-solving, and a commitment to maintaining high-quality and safety standards while collaborating with a team of scientific and manufacturing professionals.

Responsibilities

• Execute manufacturing batch records, work instructions, and SOPs with a proactive focus on accurate, ‘right the first time’ completion.
• Assist with batch record reconciliation to ensure documentation is complete and accurate.
• Support all departmental functions by maintaining suites, supplies, equipment, logbooks, and data in accordance with site SOPs and policies.
• Document all activities to meet cGMP requirements, including completing document reviews, revisions, daily record reviews, and updating tasks and databases.
• Actively provide feedback on documentation, processes, and workflows to support continuous improvement.
• Participate in and, when needed, lead shift exchanges, one-on-one discussions, and meetings to support area needs and respond to changes, including lean activities.
• Support quality investigations by answering questions, providing feedback, and suggesting process improvements.
• Practice and promote safe work habits and adhere to all safety procedures and guidelines.
• Critically evaluate processes with foresight, identifying potential issues and opportunities to improve efficiency and compliance.
• Interpret production schedules, prioritize tasks appropriately, and complete work according to schedule requirements.
• Maintain aseptic technique and cleanroom discipline at all times while performing downstream processing activities.
• Contribute subject matter expertise on downstream processing steps, as applicable, to support team performance and training.
• Collaborate effectively with cross-functional teams in manufacturing, operations, and laboratory settings to meet production goals.

Work Environment

This role is based in a cleanroom, aseptic suite environment where strict gowning and contamination control procedures are required. Team members wear full gowning suits, including bodysuits, gloves, hair and beard nets, face covers, and safety glasses. Cleanroom gowning requirements include wearing Tyvek garments and Nitrile and/or Latex gloves. Certain personal items and products are not permitted in the cleanroom, including makeup, jewelry, nail polish, cologne or perfume, and scented lotions or hair care products. The position initially trains Monday through Friday on a day schedule for approximately 4 to 6 weeks, then transitions to their shift on a rotating two-week schedule: Week 1 (off Sunday, work Monday–Wednesday, off Thursday–Friday, work Saturday) and Week 2 (work Sunday, off Monday–Tuesday, work Wednesday–Friday, off Saturday). The environment is highly regulated, focused on safety, quality, and cGMP compliance, and offers exposure to large-scale biological and chemistry pharmaceutical operations producing biologics used in pharmaceutical products.

This is a Contract to Hire position based out of Saint Louis, MO.

The pay range for this position is $30.00 - $30.00/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following: • Medical, dental & vision • Critical Illness, Accident, and Hospital • 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available • Life Insurance (Voluntary Life & AD&D for the employee and dependents) • Short and long-term disability • Health Spending Account (HSA) • Transportation benefits • Employee Assistance Program • Time Off/Leave (PTO, Vacation or Sick Leave)

This is a fully onsite position in Saint Louis,MO.

This position is anticipated to close on Aug 24, 2026.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 20,000 consultants and 5,000 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500. We are proud to be an Engineering News-Record (ENR) Top 500 Design Firm for our engineering design services and a ClearlyRated Best of Staffing® winner for both client and talent service.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email actalentaccommodation@actalentservices.com for other accommodation options.

San Francisco Fair Chance Ordinance: Pursuant to the San Francisco Fair Chance Ordinance, for all positions located in the city and county of San Francisco, we will consider for employment qualified applicants with arrest and conviction records.

Massachusetts Lie Detector: It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Use of Artificial Intelligence (AI): We may use Artificial Intelligence (AI) to support parts of our hiring process, including sourcing, screening, and evaluating candidates. AI helps assess applications and qualifications, but final decisions are made by our hiring team. By applying, you acknowledge and agree that your application may be reviewed using AI tools.