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Downstream Processing Jobs in New York (NOW HIRING)

MSD

Manager, Process Operations

Rahway, NJ

Strong understanding of GMP manufacturing environments, including upstream and downstream processing. * Working knowledge of cGMP, Quality Systems, and EHS requirements. * Ability to train employees ...

Sanofi EU

Production Technician

Newark, NJ · On-site

$24 - $32/hr

Duties will include the operation, maintenance, cleaning and sanitization of all downstream processing equipment such as stainless-steel vessels including transfer lines, ancillary equipment (tube ...

Sanofi EU

Production Technician

Paterson, NJ · On-site

$24 - $32/hr

Duties will include the operation, maintenance, cleaning and sanitization of all downstream processing equipment such as stainless-steel vessels including transfer lines, ancillary equipment (tube ...

Sanofi EU

Production Technician

Manhattan, NY

$24 - $32/hr

Duties will include the operation, maintenance, cleaning and sanitization of all downstream processing equipment such as stainless-steel vessels including transfer lines, ancillary equipment (tube ...

Sanofi EU

Production Technician

Pearl River, NY · On-site

$24 - $32/hr

Duties will include the operation, maintenance, cleaning and sanitization of all downstream processing equipment such as stainless-steel vessels including transfer lines, ancillary equipment (tube ...

Sanofi EU

Production Technician

Jersey City, NJ · On-site

$24 - $32/hr

Duties will include the operation, maintenance, cleaning and sanitization of all downstream processing equipment such as stainless-steel vessels including transfer lines, ancillary equipment (tube ...

Sanofi EU

Production Technician

Yonkers, NY · On-site

$24 - $32/hr

Duties will include the operation, maintenance, cleaning and sanitization of all downstream processing equipment such as stainless-steel vessels including transfer lines, ancillary equipment (tube ...

Merck & Co.

Manager, Process Operations

Rahway, NJ · On-site

Strong understanding of GMP manufacturing environments, including upstream and downstream processing.Working knowledge of cGMP, Quality Systems, and EHS requirements.Ability to train employees in ...

Scadea

Java Developer

New York, NY · On-site

$55.75 - $72.25/hr

Familiarity with or interest in the trade lifecycle (e.g., order capture, execution, downstream processing). * Market Concepts: Basic understanding of execution workflows, market data, or order ...

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Downstream Processing information

What is downstream processing?

A Downstream Processing (DSP) job involves purifying and recovering biomolecules, such as proteins or vaccines, after fermentation or cell culture. Professionals in this role use techniques like filtration, chromatography, and centrifugation to ensure product purity and quality. They work in industries like pharmaceuticals, biotechnology, and bioprocessing. Key responsibilities include optimizing purification processes, troubleshooting equipment, and ensuring compliance with regulatory standards.

What are the typical daily responsibilities of someone working in downstream processing?

In Downstream Processing, your daily activities often include operating and optimizing purification systems, conducting in-process testing, and meticulously documenting process parameters and results. You’ll collaborate closely with upstream teams, quality control labs, and engineering staff to troubleshoot and improve workflows. Managing equipment maintenance, adhering to safety and compliance standards, and actively participating in process development projects are also key facets of the job. This hands-on role is essential for ensuring the purity and consistency of biopharmaceutical products.

What are the key skills and qualifications needed to thrive in downstream processing, and why are they important?

To thrive in Downstream Processing, you typically need a background in biochemistry, chemical engineering, or a related field, along with experience in purification and separation techniques. Familiarity with technical tools such as chromatography systems, filtration units, and process control software, as well as cGMP certification, is often required. Strong attention to detail, problem-solving skills, and effective teamwork are valuable soft skills for this role. These competencies ensure efficient production, product quality, and compliance in highly regulated biopharmaceutical environments.

What does downstream processing involve?

Downstream processing involves the purification and recovery of products such as proteins, enzymes, or pharmaceuticals from bioreactors. It includes steps like filtration, chromatography, and concentration to ensure product quality and safety, often requiring knowledge of bioprocessing techniques and quality control standards.

What are popular job titles related to Downstream Processing jobs in New York?

For Downstream Processing jobs in New York, the most frequently searched job titles are:

What job categories do people searching Downstream Processing jobs in New York look for?

The top searched job categories for Downstream Processing jobs in New York are:

Downstream Processing jobs near you
Infographic showing various Downstream Processing job openings in New York as of August 2026, with employment types broken down into 74% Full Time, and 26% Contract. Highlights an 68% In-person, 16% Hybrid, and 16% Remote job distribution.

Senior Scientist, Process Development (AAV)

Lexeo Therapeutics

New York, NY • Hybrid

$136K - $172K/yr

Full-time

Re-posted 15 days ago

Job description

Role Summary 

The Senior Scientist supports development, optimization, and scale-up of AAV manufacturing processes using Sf9/baculovirus and HEK-based systems. This role contributes to early and late-stage CMC activities including process characterization, technology transfer, control strategy development, and regulatory documentation. The level of responsibility, technical leadership, and cross-functional ownership will be commensurate with experience. 

Primary Responsibilities
  • Design, execute, and lead process development and optimization studies for AAV manufacturing using Sf9 cells/baculovirus and HEK platforms.
  • Perform hands-on laboratory work to execute process development and optimization experiments, generate critical process data, and support technical troubleshooting.
  • Support and, as appropriate, define study designs to drive process optimization, scalability, robustness, and technology transfer for clinical and late-stage programs.
  • Collaborate with and provide technical leadership across upstream, downstream, analytical, manufacturing, and quality teams to evaluate process performance and product quality.
  • Support or own late-stage CMC deliverables, including process characterization, risk assessments, control strategy development, technology transfer, and validation readiness.
  • Author, review, and provide technical input for study protocols, technical reports, and regulatory documentation.
  • Support or lead troubleshooting, investigations, mentoring of junior staff, and continuous process improvement initiatives. 
Required Skills and Qualifications
  • Master's degree in biochemical engineering, bioprocess engineering, molecular biology, cell biology, or relevant life sciences or engineering discipline with a minimum of 6 years of relevant experience, or PhD with at least 3 years of relevant experience.
  • Hands-on experience with upstream AAV production using Sf9 cells/baculovirus and HEK platforms required.
  • Understanding of virus/viral vector properties and experience with development of upstream and downstream processes for viral vectors or gene therapy products are highly desirable.
  • Working knowledge of downstream processing and analytical testing preferred.
  • Experience supporting process optimization, characterization, and late-stage CMC activities preferred.
  • Demonstrated leadership in process development, cross-functional collaboration, and late-stage CMC readiness is expected.
  • Experience authoring and reviewing regulatory documentation preferred. 
$136,200 - $172,000 a year
Compensation is dependent on qualifications and experience

About LEXEO  

Lexeo Therapeutics is a clinical-stage genetic medicine company headquartered in New York City, pioneering cardiac genetic medicine candidates to treat the root causes of inherited cardiovascular diseases. Our lead program, LX2006, targets cardiomyopathy associated with Friedreich's Ataxia and anchors a broader pipeline addressing genetically defined conditions such as hypertrophic and arrhythmogenic cardiomyopathies. Backed by a strong financial foundation, Lexeo is positioned to translate groundbreaking science into durable clinical impact. 

Our work culture is a hybrid model with 2 days in the New York City office and 3 days working from home.   

LEXEO Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment. 

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
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