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Downstream Process Jobs in Washington (NOW HIRING)

Quality Agents

Process Engineer

Rockville, MD · On-site

The ideal candidate brings hands-on experience in biotech or pharmaceutical process engineering, with a focus on upstream, downstream or cell therapy operations. Key Responsibilities Support the ...

Quality Agents, LLC

Process Engineer

Rockville, MD

The ideal candidate brings hands-on experience in biotech or pharmaceutical process engineering, with a focus on upstream, downstream or cell therapy operations. Key Responsibilities Support the ...

Quality Agents, LLC

Process Engineer

Rockville, MD · On-site

The ideal candidate brings hands-on experience in biotech or pharmaceutical process engineering, with a focus on upstream, downstream or cell therapy operations. Key Responsibilities • Support the ...

GAP SOLUTIONS INC

Biologist (50849)

Gaithersburg, MD · On-site

Develop downstream (purification) processes, under the supervision of a project lead scientist, for recombinant proteins, virus vaccines, and virus-like particles (VLP) that may be used as clinical ...

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Downstream Process information

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$15

$27

$40

How much do downstream process jobs pay per hour?

As of Jun 22, 2026, the average hourly pay for downstream process in Washington is $27.94, according to ZipRecruiter salary data. Most workers in this role earn between $22.31 and $31.88 per hour, depending on experience, location, and employer.

What are some common challenges faced by professionals working in downstream process roles within biomanufacturing?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What are the key skills and qualifications needed to thrive as a Downstream Process Engineer, and why are they important?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What is a Downstream Process in biotechnology?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.
What are popular job titles related to Downstream Process jobs in Washington? For Downstream Process jobs in Washington, the most frequently searched job titles are:
What job categories do people searching Downstream Process jobs in Washington look for? The top searched job categories for Downstream Process jobs in Washington are:
What cities in Washington are hiring for Downstream Process jobs? Cities in Washington with the most Downstream Process job openings:
Downstream Process jobs near you

Senior Process Engineer (Pharmaceuticals)

pondco

Washington, DC • On-site

$117K - $152K/yr

Other

This job post has expired today. Applications are no longer accepted.

Job description

About the Position

We are seeking a Senior Process Engineer with experience in Pharmaceutical design to join our growing Life Science & Industrial team.

The ideal candidate will have 10+ years of relevant experience in Pharmaceutical Process Systems Design and a passion for growth, collaboration, and innovation.

Design projects will span multiple markets and geographies, providing opportunities to broaden your knowledge and deepen your expertise. We are looking for someone who is an independent self-starter and can move quickly and efficiently through various design stages, from concept planning to construction documentation.

Experience and Qualifications

  • Bachelor’s Degree in Chemical, Biochemical, or Mechanical Engineering from an accredited college or university
  • 10+ years experience in Pharmaceutical or Biotech process design engineering.
  • Experience in upstream or downstream process design, cGMP design, and process validation.
  • Experience supporting all levels of design from feasibility studies through detailed design, construction support, commissioning, and validation.
  • Experience with equipment selection for product line development and utilities including  clean utilities, CIP, SIP, and WFI systems.
  • Experience with debottlenecking and optimization of existing facilities.
  • Advanced experience in cGMP engineering design principles and applicable guides, codes, and standards.
  • Experience in developing scope of work, estimating, and scheduling professional man-hours for projects.
  • Full understanding of process design and managing process engineering work.
  • Ability to lead a small team on a project and deliver presentations to clients
  • Ability to generate complete process engineering documents and review vendor drawings and specifications
  • Ability to develop process flow diagrams, piping and instrumentation diagrams, equipment datasheets and cost studies. Support development of layouts.
  • Ability to size and generate specifications for equipment and URS.
  • Familiarity with specification and installation of equipment, piping, and instruments.
  • Ability to mentor and train Junior engineers.
  • Experienced in process simulation (i.e., ASPEN One, CHEMCAD, Promax, PRO II, or similar)
  • Experienced in Hydraulic software ( i.e. AFT Fathom, Arrow, PIPE-FLO)
  • Experienced in drafting software (i.e., AutoCAD, MicroStation)
  • Proficient in the use of Microsoft Word, Excel, PowerPoint, and Outlook
  • Excellent written and verbal communication skills
  • Proficient in Microsoft Office (Microsoft word, Excel, Power Point, Outlook etc.)
  • Ability to work well within a team environment, positive attitude, multi-task, and self-motivated to produce high quality work
  • Ability and desire to learn and grow professionally
  • Ability to travel 25% - While most travel would be domestic, this position could have the opportunity for international travel in which case a valid passport would be necessary

Preferred Qualifications

  • Professional Engineering License
  • Experience in small or large molecule pharmaceutical design
  • Experience in biologics design
  • Experience in scale up from lab or pilot scale to manufacturing or commercial production
  • Experience designing for CMO or CDMO Clients

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