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Downstream Process Jobs in Michigan (NOW HIRING)

Centraprise Corp

PLM Program Manager

Auburn, MI · On-site

$100K - $100K/yr

... and downstream systems • Manage program risks, dependencies, and delivery outcomes, with focus on process convergence, data readiness, and stakeholder alignment to ensure successful adoption ...

Gentex

Software Requirements Manager

Zeeland, MI · On-site

Monitor effectiveness of work products in supporting downstream processes and adjust as needed. * Perform duties related to managing a team of direct reports including recruiting, training, retaining ...

Epredia

Order to Cash Cycle Manager

Kalamazoo, MI · On-site

$18.50 - $24.50/hr

... downstream processes such as fulfillment, billing, and collections; lead training and cross-functional education to drive process consistency. Invoice Batching and Delivery: * Oversee the daily order ...

Epredia

Order to Cash Cycle Manager

Kalamazoo, MI · Hybrid

$18.50 - $24.50/hr

... downstream processes such as fulfillment, billing, and collections; lead training and cross-functional education to drive process consistency. Invoice Batching and Delivery: * Oversee the daily order ...

CSAA

In order for your application to be correctly processed please sign-in before you apply Internal ... Validate integrations and data outcomes by reconciling source vs. hub vs. downstream results ...

Magna

Auditor, Quality

Boyne City, MI

Provide quality direction and disposition to operators and direct support/communication with area supervisors to acknowledge and inform them of any issues within the process. * Provide downstream ...

Sentinel

Quote Management Specialist

Grand Rapids, MI · On-site +1

$62K - $75K/yr

Sync completed ConnectWise CPQ quotes to NetSuite for review and downstream processing. * Support Account Managers and sales support teams with quote management tasks. * Request or coordinate ...

Sentinel

Quote Management Specialist

Grand Rapids, MI · On-site +1

$62K - $75K/yr

Sync completed ConnectWise CPQ quotes to NetSuite for review and downstream processing. * Support Account Managers and sales support teams with quote management tasks. * Request or coordinate ...

Magna

Auditor, Quality

Boyne City, MI · On-site

Provide quality direction and disposition to operators and direct support/communication with area supervisors to acknowledge and inform them of any issues within the process. * Provide downstream ...

Sentinel

Quote Management Specialist

Grand Rapids, MI · On-site +1

$62K - $75K/yr

Sync completed ConnectWise CPQ quotes to NetSuite for review and downstream processing. * Support Account Managers and sales support teams with quote management tasks. * Request or coordinate ...

Stefanini

3DX Product Manager

Dearborn, MI · On-site

Design and implement robust processes for managing the 150% Over-Complete BOM and generating precise 100% Configured BOMs for downstream procurement and manufacturing. Define the integration points ...

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Downstream Process information

What are some common challenges faced by professionals working in downstream process roles within biomanufacturing?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What are the key skills and qualifications needed to thrive as a Downstream Process Engineer, and why are they important?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What is a Downstream Process in biotechnology?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.
What are popular job titles related to Downstream Process jobs in Michigan? For Downstream Process jobs in Michigan, the most frequently searched job titles are:
What job categories do people searching Downstream Process jobs in Michigan look for? The top searched job categories for Downstream Process jobs in Michigan are:
Downstream Process jobs near you
Infographic showing various Downstream Process job openings in Michigan as of July 2026, with employment types broken down into 18% Locum Tenens, 74% Full Time, 4% Part Time, 3% Contract, and 1% Summer. Highlights an 85% Physical, 4% Hybrid, and 11% Remote job distribution.
PLM Program Manager

PLM Program Manager

Centraprise Corp

Auburn, MI • On-site

$100K - $100K/yr

Other

Posted 19 days ago

Job description

Must Have Technical/Functional Skills
• 10+ yrs experience with at least 1–2 Greenfield PLM programs
• Strong Teamcenter / PLM implementation exposure
• Proven process harmonization across business units
• Hands-on with data migration + integrations
• Managed global programs (multi-geo, multi-stakeholder)
• Automotive domain exposure 
 
Roles & Responsibilities
• Lead end-to-end greenfield PLM (OnePLM) implementation, covering discovery, process harmonization, solution design, build, data migration, testing, and rollout phases 
• Drive enterprise-wide process harmonization, translating AS‑IS to TO‑BE PLM processes and ensuring alignment and sign-off across multiple business units 
• Establish and manage program governance, including stakeholder engagement, steering committee cadences, decision frameworks, and escalation management
• Ensure comprehensive requirements definition and sign-offs by engaging business SMEs early and controlling scope to avoid downstream rework and delays 
• Oversee data migration and system integration strategy, including legacy PLM/PDM consolidation and integration with CAD, ERP, and downstream systems 
• Manage program risks, dependencies, and delivery outcomes, with focus on process convergence, data readiness, and stakeholder alignment to ensure successful adoption
 
Generic Managerial Skills, If any
•  Strong stakeholder management & executive communication, with ability to drive alignment across business, IT, and leadership teams
• Effective program governance & decision-making, managing priorities, escalations, and ensuring timely outcomes in complex multi-stakeholder environments
• Proactive risk & dependency management, identifying critical issues early and driving mitigation to protect program timelines, cost, and quality

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