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Downstream Process Development Jobs in New York (NOW HIRING)

Neion Bio

Head of Biologics

Manhattan, NY · On-site

$170K - $230K/yr

Lead Neion Bio's protein development function, including downstream process development, analytical development, product characterization, and regulatory strategy and interactions * Define product ...

Neion Bio

Head of Biologics

Manhattan, NY · On-site

$170K - $230K/yr

Lead Neion Bio's protein development function, including downstream process development, analytical development, product characterization, and regulatory strategy and interactions * Define product ...

Neion Bio

Head of Biologics

New York, NY · On-site

$170K - $230K/yr

Lead Neion Bio's protein development function, including downstream process development, analytical development, product characterization, and regulatory strategy and interactions * Define product ...

Pathos

Director, CMC - Biologics & ADC

Manhattan, NY · On-site

$210 - $250/hr

This individual will own upstream and downstream process development, analytical development, and ADC conjugation/manufacturing -- from early clinical supply through late-stage development ...

Pathos

Director, CMC - Biologics & ADC

New York, NY · On-site

$210K - $250K/yr

This individual will own upstream and downstream process development, analytical development, and ADC conjugation/manufacturing - from early clinical supply through late-stage development - ensuring ...

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Downstream Process Development information

What is downstream process development?

A Downstream Process Development job involves optimizing and scaling purification processes for biologics, such as proteins, antibodies, or gene therapies. Scientists and engineers in this role develop efficient methods for isolation, purification, and formulation of therapeutic products while ensuring quality and regulatory compliance. Key activities include chromatography, filtration, and process analytics to improve yield, purity, and consistency. This role is critical in biotech and pharmaceutical industries to ensure safe and effective drug production for clinical and commercial use.

What does someone in downstream process development do?

Professionals in Downstream Process Development are typically responsible for designing, optimizing, and scaling up purification processes for biopharmaceutical products. Their day-to-day work may involve conducting laboratory experiments, analyzing data, troubleshooting technical issues, and documenting process changes in accordance with regulatory standards. They also frequently collaborate with upstream processing, analytical, and quality teams to ensure seamless transfer and integration of processes. The role often includes participating in project meetings, contributing to process validation efforts, and supporting technology transfer to manufacturing teams, making it both technically challenging and collaborative.

What are the key skills and qualifications needed for downstream process development?

To excel in Downstream Process Development, you generally need a strong background in biochemistry, chemical engineering, or a related life sciences field, often with experience in bioprocessing or purification technologies. Familiarity with chromatography systems, filtration equipment, process analytical technology (PAT), and relevant software such as DeltaV or Unicorn is frequently required, along with knowledge of GMP and regulatory standards. Excellent problem-solving, project management, and cross-functional communication skills help professionals succeed in dynamic team environments. These competencies are crucial for developing efficient, scalable purification processes that ensure high product quality and support organizational goals.

What are the most commonly searched types of Downstream Process Development jobs in New York?

The most popular types of Downstream Process Development jobs in New York are:

What job categories do people searching Downstream Process Development jobs in New York look for?

The top searched job categories for Downstream Process Development jobs in New York are:

What cities in New York are hiring for Downstream Process Development jobs?

Cities in New York with the most Downstream Process Development job openings:

Downstream Process Development jobs near you
Infographic showing various Downstream Process Development job openings in New York as of August 2026, with employment types broken down into 1% As Needed, 81% Full Time, 16% Part Time, and 2% Contract. Highlights an 90% Physical, 3% Hybrid, and 7% Remote job distribution.

Senior Scientist, Process Development (AAV)

Lexeo Therapeutics

New York, NY • Hybrid

$136K - $172K/yr

Full-time

Re-posted 6 days ago

Job description

Role Summary 

The Senior Scientist supports development, optimization, and scale-up of AAV manufacturing processes using Sf9/baculovirus and HEK-based systems. This role contributes to early and late-stage CMC activities including process characterization, technology transfer, control strategy development, and regulatory documentation. The level of responsibility, technical leadership, and cross-functional ownership will be commensurate with experience. 

Primary Responsibilities
  • Design, execute, and lead process development and optimization studies for AAV manufacturing using Sf9 cells/baculovirus and HEK platforms.
  • Perform hands-on laboratory work to execute process development and optimization experiments, generate critical process data, and support technical troubleshooting.
  • Support and, as appropriate, define study designs to drive process optimization, scalability, robustness, and technology transfer for clinical and late-stage programs.
  • Collaborate with and provide technical leadership across upstream, downstream, analytical, manufacturing, and quality teams to evaluate process performance and product quality.
  • Support or own late-stage CMC deliverables, including process characterization, risk assessments, control strategy development, technology transfer, and validation readiness.
  • Author, review, and provide technical input for study protocols, technical reports, and regulatory documentation.
  • Support or lead troubleshooting, investigations, mentoring of junior staff, and continuous process improvement initiatives. 
Required Skills and Qualifications
  • Master’s degree in biochemical engineering, bioprocess engineering, molecular biology, cell biology, or relevant life sciences or engineering discipline with a minimum of 6 years of relevant experience, or PhD with at least 3 years of relevant experience.
  • Hands-on experience with upstream AAV production using Sf9 cells/baculovirus and HEK platforms required.
  • Understanding of virus/viral vector properties and experience with development of upstream and downstream processes for viral vectors or gene therapy products are highly desirable.
  • Working knowledge of downstream processing and analytical testing preferred.
  • Experience supporting process optimization, characterization, and late-stage CMC activities preferred.
  • Demonstrated leadership in process development, cross-functional collaboration, and late-stage CMC readiness is expected.
  • Experience authoring and reviewing regulatory documentation preferred. 
Compensation is dependent on qualifications and experience

About LEXEO  

Lexeo Therapeutics is a clinical-stage genetic medicine company headquartered in New York City, pioneering cardiac genetic medicine candidates to treat the root causes of inherited cardiovascular diseases. Our lead program, LX2006, targets cardiomyopathy associated with Friedreich’s Ataxia and anchors a broader pipeline addressing genetically defined conditions such as hypertrophic and arrhythmogenic cardiomyopathies. Backed by a strong financial foundation, Lexeo is positioned to translate groundbreaking science into durable clinical impact.   

Our work culture is a hybrid model with 2 days in the New York City office and 3 days working from home.   

LEXEO Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment. 

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.