ZipRecruiter

Log In

1

Internship Downstream Process Development Jobs in New York

MSD

Biologics Process R&D Senior Scientist

Rahway, NJ · On-site

$100K - $127K/yr

Process Cell Sciences (PCS), Upstream and Downstream Process Development & Engineering. The latter two together form our Process Development (PD) group that works on both the early- and late-stage ...

MSD Malaysia

Biologics Process R&D Scientist

Rahway, NJ · On-site

$125 - $150/hr

Process Cell Sciences (PCS), Upstream Process, and Downstream Process Development & Engineering. The latter two together form our Process Development (PD) group that works on both the early- and late ...

MSD

Biologics Process R&D Scientist

Rahway, NJ · On-site

Process Cell Sciences (PCS), Upstream Process, and Downstream Process Development & Engineering. The latter two together form our Process Development (PD) group that works on both the early- and late ...

Merck & Co.

Biologics Process R&D Scientist

Rahway, NJ · On-site

Process Cell Sciences (PCS), Upstream Process, and Downstream Process Development & Engineering. The latter two together form our Process Development (PD) group that works on both the early- and late ...

next page

Showing results 1-20

All JobsDownstream Process Development JobsInternship Downstream Process Development JobsInternship Downstream Process Development Jobs in New York

Internship Downstream Process Development information

What is an internship in downstream process development?

An Internship in Downstream Process Development is a temporary position, typically for students or recent graduates, focused on learning and supporting the processes involved in purifying and formulating biopharmaceutical products after the initial production stage. Interns in this field gain hands-on experience with techniques such as filtration, chromatography, and quality control, and often work within a research and development or manufacturing environment. This internship helps build skills in laboratory methods, data analysis, and process optimization, making it valuable for those interested in careers in biotechnology or pharmaceuticals.

What types of hands-on projects can I expect to work on during an internship in downstream process development?

As an intern in Downstream Process Development, you will typically assist with projects focused on purification and recovery of biological products, such as proteins or antibodies, from complex mixtures. This often includes tasks like preparing chromatography columns, performing filtration techniques, and conducting sample analysis using methods such as SDS-PAGE or HPLC. You’ll also collaborate closely with experienced scientists and engineers, participate in team meetings to review data, and help troubleshoot process challenges. These experiences provide valuable insight into both laboratory workflows and the broader bioprocess development pipeline.

What are the key skills and qualifications needed to thrive as an internship in downstream process development, and why are they important?

To thrive in an Internship Downstream Process Development role, a solid background in biotechnology, chemical engineering, or a related field, along with foundational lab skills, is essential. Familiarity with bioprocessing techniques, analytical instruments, and data analysis software is typically required, and experience with GMP environments can be advantageous. Strong problem-solving abilities, attention to detail, and effective communication are important soft skills for collaborating with team members and documenting results. These competencies ensure interns can contribute to optimizing purification processes and maintaining high standards in biopharmaceutical development.

What is the difference between Internship Downstream Process Development vs Downstream Process Technician?

AspectInternship Downstream Process DevelopmentDownstream Process Technician
CredentialsTypically pursuing or holding a degree in biotech, chemistry, or related fieldsUsually requires technical diploma or associate degree in biotech or related areas
Work EnvironmentLaboratory and development settings, focusing on process optimization and experimental workManufacturing floor, operating equipment, and performing process runs
ResponsibilitiesAssisting in process development, data analysis, and protocol documentationExecuting downstream processing steps, equipment setup, and process monitoring

In summary, Internship Downstream Process Development focuses on learning and supporting process optimization in a lab setting, while Downstream Process Technicians handle the hands-on execution of downstream manufacturing processes in production environments.

What cities in New York are hiring for Internship Downstream Process Development jobs?

Cities in New York with the most Internship Downstream Process Development job openings:

Internship Downstream Process Development jobs near you

Principal Engineer, Lentivirus Downstream Process Development

Somerset, NJ • On-site

Legend Biotech US
See more jobs at Legend Biotech USexternal

Full-time

Re-posted 11 days ago

Key responsibilities

  • Design, optimize, and scale purification processes for lentiviral vectors including clarification, chromatography, and TFF.

  • Build and apply mechanistic, hybrid, and in silico process models using engineering principles and data analytics to improve downstream processing.

  • Lead the translation of bench-scale processes to GMP manufacturing, ensuring seamless technology transfer and troubleshooting during clinical production.

Job description

Legend Biotech is seeking a Principal Engineer, Lentivirus Downstream Process Development as part of the Technical Development team based in Somerset, NJ.

Role Overview

The Principal Engineer, Lentivirus Downstream Process Development, will be a key technical leader responsible for designing, optimizing, and scaling purification processes for lentiviral vectors (LVV) within our
innovative pipeline. This role focuses on delivering high-quality vector products to support LVV generation and other advanced cell therapy programs. The successful candidate will drive scientific excellence in scaling automation capabilities from concept to operation, integrating analytics, and modeling into downstream workflows, and translating microscale insights into robust, scalable processes-ensuring processes are robust, scalable, and phase-appropriate for GMP manufacturing.

Key Responsibilities

  • Build state-of-the-art mechanistic and hybrid models that directly influence the development of LVV downstream processing, build operational efficiency by model-first and AI-enabled development strategies.
  • Apply core engineering concepts including mass transfer, fluid mechanics, and thermodynamics to build robust in silico process models.
  • Perform data analytics using ML algorithms for modelling and clustering to generate process insights.
  • Working closely with team to implement development and optimization of downstream processes including and not limited to: clarification (depth filtration, centrifugation), chromatography (AEX, SEC, HIC), and Tangential Flow Filtration (TFF) for concentration and diafiltration.
  • Direct the translation of bench-scale processes to GMP manufacturing by simulation plus wet lab, ensuring seamless technology transfer and providing troubleshooting support during clinical production runs.
  • Design/ Implement different Advanced Process Control (APC) strategy (e.g., MPC, State Estimators) to optimise process performance.
  • Communicate the potential for issues and delays along with solutions and mitigation approaches.
  • In collaboration with the Senior Leaders, CMC Project Manager, Project Leader, and other technical leads identify project acceleration opportunities.
  • Leverage advanced science and technology to maximize vector recovery, purity, and potency, identifying creative solutions to define unknowns in the viral vector field.
  • Guide a team of scientists in the execution of project-specific activities, fostering a culture of transparency, scientific rigor, and continuous improvement.
  • Author and serve as a primary reviewer for technical documents, including development reports, SOPs, and CMC sections for regulatory submissions (IND/IMPD).
  • Work closely with Upstream Process Development and Analytical Development teams to ensure integrated and holistic process outcomes.
  • Tech transfer process to/from other Legend sites or CDMOs
  • Resolve conflict and proactively identify/address performance issues.
  • Ensure compliance with regulatory requirements.

Requirements

  • Advanced degree (PhD preferred, or MS) in Chemical Engineering, Biomedical Engineering, bioprocessing engineering or a related field.
  • 8+ years (PhD) or 10+ years (MS) of experience in process development or manufacturing within a biotech or pharmaceutical setting.
  • Strong engineering knowledge of the bioprocessing modeling/simulation and the interaction of biomolecules, materials and machinery.
  • Experience with modeling software and programming language such as Python and MATLAB.
  • Deep technical experience in purification, chromatography, and TFF. 
  • Strong understanding of GMP manufacturing requirements and CMC strategies for early-phase and late phase clinical trials. 
  • Deep knowledge in lentiviral vector technologies within the current emerging field
  • Excellent leadership, emotional intelligence, and communication skills; ability to maintain composure and strategic focus during challenging development timelines.
  • Creative, strategic thinking
  • Strong troubleshooting skills
  • Preferred experience in developing vector processes tailored for in vivo CAR-T generation and systemic delivery
  • Preferred experience in large scale(>50L) purification process
  • Language(s): English. Mandarin is a plus

#Li-JR1

#Li-Onsite

Apply