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Downstream Manufacturing Supervisor Jobs (NOW HIRING)

Ichor Systems

Manufacturing Supervisor

Fremont, CA · On-site

$99K - $169K/yr

Oversee saw operations to ensure materials are processed and delivered on schedule to downstream ... related manufacturing. * Experience supervising saw cutting operations for metal materials ...

Ichor Systems

Manufacturing Supervisor

Fremont, CA

$99K - $169K/yr

Ichor Systems is seeking an experienced and motivated Manufacturing Supervisor to oversee daily ... Oversee saw operations to ensure materials are processed and delivered on schedule to downstream ...

Avid Bioservices, Inc.

$80 - $100/hr

The Supervisor, Manufacturing Downstream is responsible for the supervision of Downstream manufacturing staff and operations as well as regularly performing hands-on operational activities. This ...

CIRCOR Aerospace

Manufacturing Supervisor

Corona, CA · On-site

$100 - $125/hr

Interface with upstream and downstream operations to address manufacturing issues affecting ... supervisory or management role. * Experience leading teams in an aerospace, defense, highly ...

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Downstream Manufacturing Supervisor information

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$30.5K

$97.6K

$153.5K

How much do downstream manufacturing supervisor jobs pay per year?

As of Sep 9, 2026, the average yearly pay for downstream manufacturing supervisor in the United States is $97,556.00, according to ZipRecruiter salary data. Most workers in this role earn between $78,000.00 and $120,500.00 per year, depending on experience, location, and employer.

What does a downstream manufacturing supervisor do?

A Downstream Manufacturing Supervisor oversees the purification and processing steps in the production of biopharmaceutical products after the initial cell culture or fermentation phase. They manage teams responsible for filtration, chromatography, and formulation to ensure products meet quality and regulatory standards. The supervisor coordinates daily operations, troubleshoots process issues, and ensures compliance with Good Manufacturing Practices (GMP). They also play a key role in training staff, optimizing workflows, and maintaining safety protocols.

What are the key skills and qualifications needed to thrive as a downstream manufacturing supervisor, and why are they important?

To thrive as a Downstream Manufacturing Supervisor, you need a strong background in bioprocessing, GMP regulations, and supervisory experience, usually backed by a degree in life sciences or engineering. Familiarity with downstream processing equipment, process control systems, and quality management software is essential. Leadership, problem-solving, and effective communication are critical soft skills for managing teams and ensuring compliance. These skills ensure efficient production, product quality, and regulatory adherence in a fast-paced manufacturing environment.

What are some common challenges faced by downstream manufacturing supervisors, and how can they be addressed?

Downstream Manufacturing Supervisors often encounter challenges such as maintaining process consistency, ensuring compliance with strict quality standards, and managing tight production schedules. Addressing these challenges requires strong organizational skills, effective communication with both upstream and downstream teams, and a proactive approach to troubleshooting equipment or process deviations. Building a culture of continuous improvement and fostering collaboration within the team are also key to overcoming obstacles and meeting production goals efficiently.

What is the difference between Downstream Manufacturing Supervisor vs Process Technician?

AspectDownstream Manufacturing SupervisorProcess Technician
CredentialsTypically requires a bachelor's degree in engineering or related fieldOften requires a diploma or associate degree in process technology or similar
Work EnvironmentSupervises production lines in manufacturing plants, overseeing teamsOperates and monitors equipment, performs troubleshooting on the production floor
Industry UsageCommonly used in pharmaceutical, chemical, and biotech manufacturingWidely used in similar industries for equipment operation and process control

The Downstream Manufacturing Supervisor oversees production teams and ensures manufacturing processes run smoothly, while the Process Technician focuses on operating and maintaining equipment. Both roles are essential in manufacturing settings, but the supervisor has a broader leadership responsibility, whereas the technician is more hands-on with daily operations.

What cities are hiring for Downstream Manufacturing Supervisor jobs?

Cities with the most Downstream Manufacturing Supervisor job openings:

What states have the most Downstream Manufacturing Supervisor jobs?

States with the most job openings for Downstream Manufacturing Supervisor jobs include:

What are popular job titles related to Downstream Manufacturing Supervisor jobs?

For Downstream Manufacturing Supervisor jobs, the most frequently searched job titles are:

Infographic showing various Downstream Manufacturing Supervisor job openings in the United States as of June 2026, with employment types broken down into 92% Full Time, 5% Part Time, and 3% Nights. Highlights an 86% Physical, 3% Hybrid, and 11% Remote job distribution, with an average salary of $97,556 per year, or $46.9 per hour.

Manufacturing Technical Specialist (Downstream)

Tustin, CA • On-site

Avid Bioservices
Pharmaceutical and Medicine Manufacturing • 51 - 200 employees
Learn more about Avid Bioservicesexternal

$25.48 - $34/hr

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 19 days ago

Job description

Description
Looking to join a passionate team dedicated to developing and manufacturing life-saving biopharmaceuticals? Avid Bioservices is a leading clinical and commercial biologics CDMO focused on creating innovative solutions to meet the needs of our clients and improve patient outcomes.
Your Role:
The primary responsibilities of the Downstream - Manufacturing Technical Specialist are to collaborate with the technical MFG Supervisor/Manager to ensure the successful transfer and execution of Downstream processes, and to serve as the main point of contact for QA, MSAT, and Facility for Downstream technical support. This role requires strong leadership skills and deep technical knowledge in scaling downstream processes, as well as an understanding of MFG Downstream equipment, processes, and the setup of Manufacturing Downstream Operations for success.
The MFG Technical Specialist supports the MFG Technical Supervisor/Manager in overseeing the transfer of all new projects and any changes to existing projects from MSAT to manufacturing. They will assist MFG Leads in the progress of technical and on-the-job training for the MFG team; as well as aid in maintaining the equipment list and calibration/PM schedule and will coordinate with Facility and MSAT to ensure successful equipment readiness for all manufacturing processes.
  • Develops and cultivates positive internal Avid group (MSAT, Facility, MFG, QA, Validations, IT, Computerized Systems/Automation, etc.) partnerships.
  • Working with MFG Technical Supervisor/Manager in Overseeing and approving the BPR, Unicorn method, BOM, and buffer and solution planning as the manufacturing stakeholder.
  • Working with MFG Technical Supervisor/Manager to identify and initiate process and procedural changes to improve performance, robustness, productivity, safety, efficiency, and compliance.
  • Communicating with Client, MSAT, and QA on Process Status and collaborating to resolve technical issues on the floor.
  • Maintaining and managing the equipment list and needs for all downstream processes. Collaborating with facility and MSAT to ensure successful and sufficient equipment allocations for all processes.
  • Reviewing Manufacturing Batch Production Records, Technical Reports, Standard Operating Procedures.
  • Leading technical training to Manufacturing Downstream Operators.
  • Supporting MFG Technical Supervisor/Manager in CAPA (Corrective Action Preventive Action) investigations and recommending dispositions for the manufacturing team.
  • Other tasks may be assigned as needed.

Minimum Qualifications:
  • B.S/M.S. in scientific or engineering (chemical or biomedical) discipline.
  • 4+ years of Experience downstream MFG with B.S and 2+ years with M.S.
  • Strong technical experience within relevant manufacturing process technologies and unit operations. Experience of commercial cGMP manufacturing.
  • Technical expertise in Downstream processes such as depth filtration, purification by affinity, ion exchange, and hydrophobic interaction chromatography, viral inactivation and filtration, tangential flow filtration, sterile filtration, and bulk drug substance fills.
  • Hands-on experience with downstream process equipment including, but not limited to AKTA ready column chromatography skids, large-scale filtration skids, Unicorn software.
  • Track record for analyzing and resolving complex manufacturing and production issues using sound scientific principles.
  • The ability to work effectively and lead small matrix and cross-functional teams in a fast-paced environment with changing priorities and a high level of urgency.
  • Highly motivated with the ability to work independently as well as on cross-functional and cross-site teams.
  • Customer service skillset via escorting of person in plant (PIP) or through prior work experience.
  • Strong knowledge of cGMPs or equivalent standards.
  • Sound decision-making skillset to resolve or escalate deviations and/or issues on the production floor.
  • Communicate clearly and professionally both in writing and verbally.
  • Proficient time management/multi-tasking and project oversite skills.
  • Strong leadership and management skillset.

Position Type/Expected Hours of Work:
This role is a full-time position operating Monday through Friday, 5x8 (5 days x 8 hours) schedule from 8am to 5pm PST unless otherwise stated by Supervisor. Must be able to work overtime, weekends, and/or holidays if needed.
Compensation:
We offer competitive compensation packages for this role, including a base salary, performance-based bonuses, and comprehensive benefits such as health, dental, and vision insurance, 401(k) matching, and paid time off.
The compensation range for this role is $25.48 to $34.00 hourly, depending on experience and qualifications. Additionally, we offer opportunities for career growth and development as well as a supportive and inclusive work environment.
Who you are:
  • You have a "bring it on!" team player approach and an unshakable positive attitude, always ready to tackle anything that comes your way.
  • Your written and verbal skills are out of this world, and you communicate with clarity and confidence.
  • You have exceptional multitasking skills and an unparalleled attention to detail that ensure the smooth running of everything.
  • You are a master at building relationships, capable of establishing connections with anyone, be it team members, clients, vendors, or suppliers.

Physical Demands & Work Environment:
In this dynamic role, expect a blend of regular activities like sitting, standing, and walking, with occasional physically engaging tasks such as lifting objects up to 20 pounds. The work environment might expose you to electrical shocks, toxic chemicals, vibrations, or loud noise levels occasionally. However, reasonable accommodations are available to enable individuals with different abilities to perform effectively, ensuring a supportive and adaptable work setting. Your visual acuity, including close, distance, and color vision, will be essential in navigating through the diverse day-to-day demands of this position.

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