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Downstream Manufacturing Associate Jobs (NOW HIRING)

Astrix Inc

Manufacturing Associate

Cary, NC · On-site

We are seeking a motivated Manufacturing Associate with 2+ years of experience in cell and gene ... Perform downstream purification using AKTA chromatography systems. * Monitor process parameters and ...

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Downstream Manufacturing Associate information

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How much do downstream manufacturing associate jobs pay per hour?

As of Sep 9, 2026, the average hourly pay for downstream manufacturing associate in the United States is $20.84, according to ZipRecruiter salary data. Most workers in this role earn between $16.35 and $23.32 per hour, depending on experience, location, and employer.

What is a downstream manufacturing associate?

Downstream Manufacturing Associates are professionals who work in the later stages of biopharmaceutical and biotechnology manufacturing processes. Their main responsibilities involve purifying and processing biological products after the initial production phase, often using techniques like filtration and chromatography. They ensure the quality and safety of the final product by following strict protocols and maintaining detailed documentation. Downstream associates often work in cleanroom environments and collaborate with other teams to meet production goals.

What are the key skills and qualifications needed to thrive as a downstream manufacturing associate?

To thrive as a Downstream Manufacturing Associate, you need a solid understanding of bioprocessing, protein purification, and GMP (Good Manufacturing Practice) standards, often gained through a degree in life sciences or related field. Familiarity with chromatography systems, filtration technologies, and process automation tools is typically required, alongside relevant safety certifications. Attention to detail, teamwork, and strong problem-solving skills are valued soft skills in this role. These qualifications are essential for ensuring the efficient, safe, and compliant production of biopharmaceutical products.

What are some typical challenges faced by downstream manufacturing associates, and how can they be addressed?

Downstream Manufacturing Associates often encounter challenges such as maintaining strict adherence to GMP (Good Manufacturing Practices), troubleshooting equipment issues, and ensuring consistent product quality during purification and filtration processes. These challenges can be addressed through thorough training, clear documentation, and effective communication within the team. Collaborating closely with upstream teams and quality control helps resolve issues quickly and ensures smooth workflow. Staying detail-oriented and proactive in identifying potential bottlenecks also contributes to success in this role.

What is the difference between Downstream Manufacturing Associate vs Upstream Manufacturing Associate?

AspectDownstream Manufacturing AssociateUpstream Manufacturing Associate
Primary ResponsibilitiesPurifies, filters, and processes final product batchesPrepares raw materials and manages initial production stages
Work EnvironmentCleanroom, laboratory, manufacturing floorManufacturing plant, laboratory, production line
Required CertificationsGMP training, OSHA safety certificationsGMP training, OSHA safety certifications
Industry UsagePharmaceutical, biotech manufacturingPharmaceutical, biotech manufacturing

Downstream Manufacturing Associates focus on final product purification and processing, while Upstream Manufacturing Associates handle raw material preparation and initial production. Both roles are essential in biopharmaceutical manufacturing, often requiring similar certifications and working in related environments.

What cities are hiring for Downstream Manufacturing Associate jobs?

Cities with the most Downstream Manufacturing Associate job openings:

What states have the most Downstream Manufacturing Associate jobs?

States with the most job openings for Downstream Manufacturing Associate jobs include:

What are popular job titles related to Downstream Manufacturing Associate jobs?

For Downstream Manufacturing Associate jobs, the most frequently searched job titles are:

Infographic showing various Downstream Manufacturing Associate job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 69% Full Time, 28% Part Time, 1% Temporary, and 1% Contract. Highlights an 96% Physical, 1% Hybrid, and 3% Remote job distribution, with an average salary of $43,341 per year, or $20.8 per hour.

Manufacturing Associate II, Downstream

San Diego, CA • On-site

Tanvex BioPharma Inc
See more jobs at Tanvex BioPharma Incexternal

$66K - $78K/yr

Full-time

Posted 29 days ago

Job description

Under general supervision, the Manufacturing Associate II, Downstream, will perform routine manufacturing activities in GMP manufacturing areas including purification and the associated sub-processes/ preparation. Operations will be performed according to Standard Operating Procedures (SOPs) and batch records. Perform manufacturing steps, execute routine batch records, and revise documents such as batch records and SOPs as needed. Flexible shift schedule and overtime may be required.
Technical:
  • Perform tasks using defined protocols or procedures which contribute to the achievement of project milestones.
  • Perform GMP manufacturing activities in assigned areas.
  • Set-up, operate, maintain and clean downstream bioprocessing equipment, which includes but is not limited to chromatography systems, UF/DF and Viral filtration skids and mixers.
  • Perform basic troubleshooting of bioprocess equipment.
  • Perform manual cleaning and sterilization of manufacturing areas, parts and components.

Compliance:
  • Follow Standard Operating Procedures (SOPs), current Good Manufacturing Practices (cGMPs), plant safety guidelines and other established procedures during the manufacturing process to produce quality products.
  • Accurately complete and maintain detail-oriented process-related documentation of equipment logs and batch records following the manufacturing Good Documentation Practices (GDP).
  • Draft and revise SOPs and batch records.

Teamwork and Communication:
  • Participate in regularly scheduled team meetings to discuss ideas, troubleshoot issues, go over lessons learned and identify future projects or tasks.
  • Address production issues and report any compliance related concerns to supervisor and/or management as soon as possible.
  • Fosters teamwork and is expected to suggest project improvements

Requirements
Education and Experience
  • Advanced degree in life sciences or related discipline with 0 years of experience in the pharmaceutical or biotech industry, or equivalent education and experience.
  • Bachelor's degree with 3 years of experience in the pharmaceutical or biotech industry, or equivalent education and experience.
  • High School Diploma/GED with 6 years of experience in the pharmaceutical or biotech industry, or equivalent education and experience.

Knowledge, Skills and Abilities:
  • Downstream/Purification experience and skills in Protein Chromatography, TFF, Depth Filtration, Viral Filtration, Bulk Drug Substance Formulation, and Final Filtration. Aseptic Sampling of process pools and buffers. Buffer Preparation, Tubing assemblies and Autoclaving Operations.
  • Knowledge of UNICORN and Common Control Platform (CCP) Software is preferred.
  • Fundamental knowledge of current biologics regulations and cGMP for drug substance operation.
  • Proficient with Microsoft Word and Excel.
  • Able to work with pressurized systems, steam, and corrosive chemicals with necessary safety precautions.
  • Demonstrated ability to follow and document activities in written procedures and/or logbooks.
  • Detail-oriented, strong team player.
  • Effective collaboration skills and the ability to work cross functionally across categories and internal stakeholders.

Salary Description
$66,421 - $78,044

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