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Director Real World Evidence Jobs (NOW HIRING)

Novo Nordisk

Real World Evidence Director

Plainsboro, NJ · On-site

$187K - $327K/yr

The Position The Director, Real World Evidence (RWE) leads the development and execution of RWE for the assigned therapeutic area or function area through serving as the principal investigator on ...

Novo Nordisk

Real World Evidence Director

Plainsboro, NJ · On-site

$187K - $327K/yr

The Position The Director, Real World Evidence (RWE) leads the development and execution of RWE for the assigned therapeutic area or function area through serving as the principal investigator on ...

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How much do director real world evidence jobs pay per year?

As of Sep 3, 2026, the average yearly pay for director real world evidence in the United States is $123,955.00, according to ZipRecruiter salary data. Most workers in this role earn between $106,000.00 and $137,000.00 per year, depending on experience, location, and employer.

What is a director of real world evidence?

A Director of Real World Evidence (RWE) is a senior professional in the healthcare or pharmaceutical industry responsible for overseeing the collection and analysis of real-world data to generate insights about the use, safety, and effectiveness of medical products. They lead teams that design and implement studies using data from sources like electronic health records, insurance claims, and patient registries. Their work helps inform regulatory decisions, support product development, and improve patient outcomes. The role requires expertise in epidemiology, data science, and regulatory requirements, as well as strong leadership and communication skills.

How does a director of real world evidence collaborate with cross-functional teams to drive evidence generation projects?

A Director of Real World Evidence (RWE) works closely with clinical, regulatory, medical affairs, biostatistics, and data science teams to design and execute studies that generate actionable insights from real-world data. This role often involves leading project teams, aligning stakeholder objectives, and ensuring that RWE strategies support both product development and post-market decision-making. Effective communication and project management skills are essential, as the Director must synthesize input from diverse experts, manage timelines, and ensure that evidence generation aligns with regulatory and business goals.

What are the key skills and qualifications needed to thrive as a director of real world evidence, and why are they important?

To thrive as a Director of Real World Evidence, you need advanced expertise in epidemiology, biostatistics, and data analytics, typically supported by a graduate degree in a related field and significant experience in pharmaceutical or healthcare research. Mastery of statistical software (such as SAS, R, or Python), familiarity with real-world data sources (like claims or EMR databases), and knowledge of regulatory guidelines are crucial. Exceptional leadership, communication, and stakeholder management skills distinguish top performers in this role. These competencies ensure robust evidence generation, effective cross-functional collaboration, and impactful decision-making that drives value for healthcare organizations.

What is the difference between Director Real World Evidence vs Clinical Data Manager?

AspectDirector Real World EvidenceClinical Data Manager
Required CredentialsAdvanced degree (PhD, MD, or Master’s), experience in RWE, biostatisticsBachelor’s or Master’s in life sciences, clinical research, or related field
Work EnvironmentStrategic, cross-functional teams, focus on observational studiesData collection, database management, clinical trial support
Employer & Industry UsagePharmaceutical, biotech companies, healthcare analyticsClinical research organizations, hospitals, pharma companies
Common Search & Comparison IntentUnderstanding senior roles in RWEOperational data management roles in clinical trials

The main difference is that the Director of Real World Evidence focuses on strategic analysis of observational data to inform healthcare decisions, while a Clinical Data Manager handles the operational aspects of managing clinical trial data. Both roles require strong scientific backgrounds but differ in scope and responsibilities.

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Director Real World Evidence jobs near you
Infographic showing various Director Real World Evidence job openings in the United States as of August 2026, with employment types broken down into 78% Full Time, 18% Part Time, 3% Contract, and 1% Nights. Highlights an 91% Physical, 2% Hybrid, and 7% Remote job distribution, with an average salary of $123,955 per year, or $59.6 per hour.

Associate Director, Real World Evidence (RWE) Science

Ubertal Inc

Waltham, MA • Remote

Contractor

Re-posted 19 days ago

Job description

Job Title: Associate Director, Real World Evidence (RWE) Science – Phase IV / Post-Approval (Contract)

Location: United States (Remote; Eastern Time business hours preferred)
Duration: 7-Month Contract (Full-Time, 40 hours/week)
Start: Targeting Early March 2026

We are seeking an experienced Associate Director, Real World Evidence (RWE) Science to provide coverage for a Phase IV / post-approval RWE portfolio within a global Medical Affairs environment. This is a senior-level individual contributor role requiring deep epidemiology and real-world evidence expertise, strong methodological leadership, and the ability to independently manage ongoing studies with minimal ramp-up.

This position supports global stakeholders, including Europe, and requires flexibility for early morning meetings aligned to EU collaboration.

Key Responsibilities

  • Lead scientific oversight of Phase IV and post-approval real-world evidence (RWE) and observational studies

  • Provide methodological and technical leadership for study design, feasibility assessments, and evidence planning (EU focus)

  • Oversee vendors/CROs conducting outsourced analyses; review protocols, statistical analysis plans, and outputs to ensure scientific rigor

  • Conduct and/or supervise systematic literature reviews (SLRs) and meta-analyses

  • Contribute to development of RWE plans aligned with regulatory, HTA, and post-approval commitments

  • Support retrospective analyses leveraging real-world data sources (claims, EHR, registries)

  • Guide protocol development for observational studies and pragmatic trials

  • Perform evidence reviews to inform regulatory submissions, reimbursement strategy, and medical strategy

  • Collaborate with Regional Medical Affairs on scientific exchange and external RWE engagement

  • Support development of abstracts, posters, manuscripts, and internal scientific communications

Required Qualifications

  • Advanced degree (MD, PhD, or MS) in Epidemiology, Biostatistics, Public Health, or related field

  • 8–10+ years of progressive experience in epidemiology and real-world evidence

  • Minimum 5 years of Pharma or Biotech industry experience

  • Strong expertise in:

    • Phase IV / post-approval epidemiologic study design

    • Retrospective real-world data (RWD) analyses

    • Observational research methodologies

  • Experience overseeing vendors/CROs and critically evaluating statistical methodologies

  • Proficiency with statistical software (R, SAS, Stata) and strong understanding of claims/EHR data structures

  • Demonstrated ability to work autonomously in a global, matrixed environment

  • Flexibility to support EU collaboration across time zones

Preferred Qualifications

  • Experience supporting regulatory or HTA-facing RWE deliverables

  • Vaccines, infectious disease, or public health epidemiology background

  • Experience with systematic literature reviews and meta-analyses

  • R programming skills, including simulations, power calculations, or Shiny applications

  • Experience with data extraction, cleaning, and standardization for RWD

  • Prior authorship of scientific publications and presentations

  • Experience supporting EU feasibility assessments and RWE expectations

Role Highlights

  • Senior-level RWE leadership without people management responsibilities

  • High-visibility Phase IV and real-world effectiveness portfolio

  • Global collaboration with strong EU engagement

  • Remote flexibility within the United States

Qualified candidates with deep RWE and epidemiology expertise, strong methodological grounding, and Phase IV experience in Pharma/Biotech are encouraged to apply.