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Director Bioinformatics information

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$31.5K

$114.7K

$189.6K

How much do director bioinformatics jobs pay per year?

As of Aug 27, 2026, the average yearly pay for director bioinformatics in Boston, MA is $114,731.00, according to ZipRecruiter salary data. Most workers in this role earn between $79,300.00 and $141,800.00 per year, depending on experience, location, and employer.

What is a director bioinformatics?

A Director of Bioinformatics leads teams that analyze complex biological data using computational tools and techniques. They oversee the development of algorithms, manage bioinformatics projects, and collaborate with scientists to interpret genomic and molecular data. Their role involves strategic planning, managing research initiatives, and ensuring that bioinformatics solutions align with organizational goals. Typically, they work in biotech, pharmaceutical, or academic settings, driving innovation through data-driven insights. Strong leadership, expertise in bioinformatics tools, and an understanding of biology and programming are essential for this role.

What are the key skills and qualifications needed to thrive as a director bioinformatics?

To thrive as a Director of Bioinformatics, you need advanced expertise in computational biology, data analytics, genomics, and a graduate degree in bioinformatics, computational biology, or a related field. Proficiency with tools like Python, R, SQL, cloud-based platforms, and bioinformatics pipelines, as well as leadership certifications, is highly valued. Outstanding candidates possess strategic thinking, excellent communication, team leadership, and project management abilities. These skills are vital for leading multidisciplinary teams, driving cutting-edge research, and delivering actionable insights in fast-evolving scientific environments.

What are some typical challenges faced by a director bioinformatics, and how can they be addressed?

A Director of Bioinformatics often faces the challenge of managing large, complex datasets and integrating diverse types of biological data from multiple sources. Balancing the needs of scientific research teams with company or institutional goals requires strong leadership and strategic prioritization. Effective collaboration with scientists, clinicians, and IT staff is essential to ensure data accuracy, platform scalability, and actionable results. Staying updated with rapidly evolving bioinformatics tools and methodologies also presents a continuous learning opportunity. Proactively investing in team training, establishing robust data management practices, and fostering open communication can help address these challenges.

What are the most commonly searched types of Bioinformatics jobs in Boston, MA?

The most popular types of Bioinformatics jobs in Boston, MA are:

What are popular job titles related to Director Bioinformatics jobs in Boston, MA?

For Director Bioinformatics jobs in Boston, MA, the most frequently searched job titles are:

What job categories do people searching Director Bioinformatics jobs in Boston, MA look for?

The top searched job categories for Director Bioinformatics jobs in Boston, MA are:

What cities near Boston, MA are hiring for Director Bioinformatics jobs?

Cities near Boston, MA with the most Director Bioinformatics job openings:

Director Bioinformatics jobs near you
Infographic showing various Director Bioinformatics job openings in Boston, MA as of August 2026, with employment types broken down into 2% As Needed, 81% Full Time, 13% Part Time, 1% Temporary, and 3% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $114,883 per year, or $55.2 per hour.

Associate Director, Bioinformatics

Rhythm Pharmaceuticals

Boston, MA • On-site

Full-time

Re-posted 15 days ago

Job description

Company Overview
Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.
Opportunity Overview
We are seeking a highly motivated Associate Director of Data Science within Rhythm's Research group and the Data Sciences Team in support of our clinical, regulatory, and scientific objectives in the rare neuroendocrine/obesity/metabolic disease. The successful candidate will have a strong background in biostatistics, genetics, and data analytics, and will be responsible for implementing advanced AI data models, predictive tools, and integrative analyses across the obesity and metabolic disease therapeutic areas. A core focus of this position will be the development and implementation of algorithmic phenotyping approaches using electronic medical records (EMR) and real-world datasets, enabling robust patient stratification, cohort definition, and integration with genomics and biomarker data. This position is ideal for a technically strong investigator who thrives in a fast-paced environment and is motivated to apply and scale high-impact data science infrastructure alongside a growing team.
Responsibilities and Duties
  • Design and deploy AI-driven, agent-based phenotyping pipelines that leverage EMR/EHR and real-world data to define disease cohorts, endpoints, and longitudinal outcomes.
  • Develop scalable approaches for cohort identification, feature extraction, and phenotype validation, including rule-based and machine learning methods.
  • Maintain high-throughput rare variant curation and classification models.
  • Execute the design, development, and deployment of data analysis pipelines, statistical models, and predictive tools to support Genetics-led programs.
  • Lead hands-on integration of clinical, EMR, genomics, and biomarker datasets, enabling multi-modal analyses.
  • Build and maintain reproducible workflows for data ingestion, harmonization (e.g., coding systems, ontologies), QC, and analysis (SQL, Python, R).
  • Apply statistical genetics and advanced analytics to link phenotypic definitions with genetic signals, including rare variant analyses.
  • Drive improvements in data infrastructure and phenotyping frameworks to support team expansion and increased dataset complexity.

Qualifications and Skills
  • Ph.D. in Biostatistics, Computational Biology, Genetics, Data Science, or related quantitative field.
  • ~5+ years of relevant experience in biotechnology, pharmaceuticals, or healthcare analytics.
  • Experience with neuroendocrine, obesity/metabolic-related biology and datasets.
  • Experience applying machine learning and AI models to real-world and clinical datasets, including model development, evaluation, and deployment in production or near-production settings.
  • Experience developing or utilizing AI-driven agents/workflows to automate data extraction, phenotyping, analysis, or knowledge generation tasks.
  • Strong hands-on expertise in SQL, Python, and R, with experience building production-quality data pipelines.
  • Experience with cloud computing and storage environments including AWS, GCP, Snowflake.
  • Demonstrated experience with variant calling pipelines, variant interpretation and ACMG rare variant classification.
  • Demonstrated experience in EMR/EHR and real-world data analysis (e.g., UK Biobank, All of Us) including cohort building and longitudinal data modeling.
  • Proven track record in algorithmic phenotyping, including use of coding systems (ICD, CPT, SNOMED), clinical ontologies, and feature engineering.
  • Familiarity with broader bioinformatics/multi-omics methodologies including RNA-seq, methylation analysis, long-read sequencing would be advantageous.
  • Strong problem-solving skills and ability to operate independently in a fast-paced, execution-focused environment.
  • Excellent communication skills with the ability to clearly present complex analytical outputs to technical stakeholders.

This role can be remote or based out of our corporate office in Boston, Massachusetts. Rhythm operates in a hybrid-work model. Candidates applying must be willing and able to be in the Boston office in coordination with their department and business needs. This role may involve some travel.
More about Rhythm
We are a dynamic and growing global team spanning more than a dozen countries. At Rhythm we are dedicated to transforming the lives of patients living with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause. Our team is passionate about expanding access to reach more patients and developing novel therapies for other rare neuroendocrine diseases, including congenital hyperinsulinism.
At Rhythm our core values are:
  • We are committed to advancing scientific understanding to improve patients' lives
  • We are inspired to tackle tough challenges and have the courage to ask bold questions
  • We are eager to learn and adapt
  • We believe collaboration and ownership are foundational for our success
  • We value the unique contribution each individual brings to furthering our mission

Inherent in our core values is the commitment to act ethically and with integrity in all we do.
Rhythm is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service, or any other class protected by state or federal law.
Headquartered in Boston, Rhythm is proud to have been named one of the Top Places to Work in Massachusetts.

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