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Computational Biology Jobs (NOW HIRING)

Mass General Brigham

Computational Associate

Boston, MA · On-site

Analyze genomic, transcriptomic, epigenomic, and spatial biology datasets. * Build computational workflows that integrate pathology images, molecular data, and clinical outcomes. * Support biomarker ...

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How much do computational biology jobs pay per year?

As of Aug 28, 2026, the average yearly pay for computational biology in the United States is $93,988.00, according to ZipRecruiter salary data. Most workers in this role earn between $70,500.00 and $117,000.00 per year, depending on experience, location, and employer.

What is computational biology?

Computational biology is an interdisciplinary field that uses data analysis, mathematical modeling, and computer simulations to understand biological systems and relationships. Researchers in this area develop algorithms and software to analyze large sets of biological data, such as DNA sequences or protein structures. Computational biology plays a crucial role in genomics, drug discovery, systems biology, and personalized medicine, helping scientists make sense of complex biological information.

What are the key skills and qualifications needed to thrive as a computational biologist, and why are they important?

To thrive as a Computational Biologist, you need a strong background in biology, statistics, and computer science, often supported by a relevant degree such as bioinformatics, computational biology, or a related discipline. Familiarity with programming languages like Python or R, experience using bioinformatics tools (e.g., BLAST, Bioconductor), and knowledge of data analysis pipelines are typically required. Strong problem-solving, collaboration, and communication skills help computational biologists interpret complex datasets and work effectively with interdisciplinary teams. These competencies are crucial for extracting meaningful biological insights from large datasets and advancing research in genomics, drug discovery, and personalized medicine.

How do computational biologists typically collaborate with experimental scientists in research projects?

Computational biologists frequently work alongside experimental biologists to interpret data, design experiments, and develop new hypotheses. Collaboration often involves regular meetings to align on research goals, data sharing, and troubleshooting analytical challenges together. Being able to communicate complex computational findings in accessible terms is crucial for ensuring that experimental teams can act on the insights provided. This interdisciplinary teamwork not only enhances research outcomes but also broadens professional skill sets, making the role both dynamic and rewarding.

What is the difference between Computational Biology vs Bioinformatics?

AspectComputational BiologyBioinformatics
Required CredentialsTypically requires a PhD in biology, bioinformatics, or related fieldsOften requires a bachelor's or master's degree in computer science, biology, or bioinformatics
Work EnvironmentResearch labs, academia, biotech companiesResearch labs, healthcare, biotech, and pharmaceutical industries
Industry UsageUsed for modeling biological systems and understanding complex biological dataPrimarily focused on developing algorithms and tools to analyze biological data

Computational Biology and Bioinformatics are closely related fields that often overlap. Computational Biology emphasizes modeling and understanding biological systems through computational methods, often requiring advanced degrees. Bioinformatics focuses on developing tools and algorithms to analyze biological data, typically with a background in computer science or biology. Both roles are vital in research and industry, but they differ in their primary focus and educational requirements.

What can you do with a computational biology degree?

A computational biology degree prepares individuals for roles such as bioinformatics analyst, research scientist, or data scientist in healthcare, biotech, and pharmaceutical industries. Graduates use skills in programming, statistical analysis, and biological data interpretation to develop models, analyze genomic data, and support drug discovery. Proficiency in tools like Python, R, and databases is often required.
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Computational Biology jobs near you
Infographic showing various Computational Biology job openings in the United States as of August 2026, with employment types broken down into 63% Full Time, 33% Part Time, 1% Temporary, and 3% Contract. Highlights an 77% Physical, 2% Hybrid, and 21% Remote job distribution, with an average salary of $93,988 per year, or $45.2 per hour.

Member of Technical Staff - Computational Biologist

Manhattan, NY • On-site

Valthos
See more jobs at Valthosexternal

Full-time

This job post has expired 2 days ago. Applications are no longer accepted.

Job description

Job Summary:
Valthos Inc. is an applied biological intelligence company focused on building and deploying software and biological AI systems. They are seeking a highly skilled Computational Biologist to bridge machine learning and biology by developing data frameworks for assessing biological threats and designing precision biologics.
Responsibilities:
• Contribute to shaping and executing the Valthos-wide research and development roadmap
• Identify large-scale biological datasets appropriate for training frontier biological models, and build workflows and infrastructure for processing these datasets
• Design, build, and apply evaluation frameworks for rigorously assessing model performance on real-world problems in biological security
• Design wet-lab experiments to evaluate the efficacy and real-world utility of designed biologics
• Collaborate closely with AI engineers to design and train models tailored to tasks in biological security and precision biologics
• Collaborate closely with software engineers to build and deploy tools for data analysis, including proper documentation and testing
• Visualize and communicate results clearly within Valthos and externally
• Work with customers and external collaborators to understand their needs and effectively represent Valthos
• Embrace continuous learning in both technical and non-technical areas across Valthos
• Stay up-to-date on state-of-the-art methods at the intersection of AI and biology
Qualifications:
Required:
• Experience analyzing biological datasets, ideally sequence-based modalities (e.g., genomic, protein, metagenomic)
• Experience planning and running in silico computational biology experiments
• High proficiency in Python and its scientific package ecosystem
• Experience with bioinformatics sequence analysis tools (e.g., aligners)
• Experience with cloud computing platforms (e.g., AWS)
Preferred:
• Proven ability to design, implement, and evaluate novel methods in computational biology
• Experience working with experimental biologists to plan and interpret the results of wet-lab experiments
• Experience with ML-centric bioinformatics and structure-based tools (e.g., AlphaFold)
• Knowledge of biological databases (e.g., NCBI)
• Experience with machine learning model training and evaluation
• Contributions to open-source projects
Company:
Valthos is an applied biological intelligence company focusing on biodefense by developing AI systems to identify biological threats. Founded in 2024, the company is headquartered in New York, USA, with a team of 11-50 employees. The company is currently Early Stage.

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