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Clinical Variant Analyst Jobs in Oregon (NOW HIRING)

Natera

Senior Product Manager, Clinical Genomics

OR · On-site +1

$126K - $166K/yr

The Clinical Genomics Engineering organization builds software that supports complex, regulated workflows spanning tertiary analysis workflows including variant interpretation, clinical review, and ...

Natera

Staff Scientist, Bioinformatics/RWD

OR · On-site +1

Expert knowledge of bioinformatics tools including mapping, variant calling, CNV analysis and ... Understanding of real-world clinical data, such as electronic health records, claims data, patient ...

All JobsClinical Variant Analyst JobsClinical Variant Analyst Jobs in Oregon

Clinical Variant Analyst information

What is a clinical variant analyst?

A Clinical Variant Analyst is a professional who interprets and analyzes genetic variants identified through clinical genetic testing. Their main role is to evaluate DNA sequence changes to determine their significance in relation to health and disease. They collaborate with geneticists, laboratory scientists, and clinicians to classify variants according to established guidelines and help inform patient diagnoses and management. Additionally, Clinical Variant Analysts review scientific literature, use databases, and may contribute to research and quality improvement in genetic testing.

What are the key skills and qualifications needed to thrive as a clinical variant analyst, and why are they important?

To thrive as a Clinical Variant Analyst, you need a strong background in genetics, molecular biology, and bioinformatics, typically supported by a relevant degree such as in genetics or molecular biology. Familiarity with next-generation sequencing (NGS) platforms, variant interpretation databases (like ClinVar), and clinical reporting software is commonly required, along with certifications such as ACMG variant interpretation training. Attention to detail, analytical thinking, and effective communication are vital soft skills for accurately interpreting genetic data and collaborating with clinical teams. These skills ensure accurate variant classification and reporting, directly impacting patient diagnosis and care.

What are some common challenges clinical variant analysts face when interpreting genetic data, and how can they be addressed?

Clinical Variant Analysts often encounter challenges such as distinguishing between benign and pathogenic variants, managing large datasets, and keeping up with rapidly evolving scientific literature. Addressing these challenges requires strong analytical skills, familiarity with bioinformatics tools, and ongoing collaboration with genetic counselors, laboratory directors, and clinicians. Staying current through continuous education and attending case discussions or multidisciplinary meetings also helps analysts provide accurate and clinically relevant interpretations.

What are popular job titles related to Clinical Variant Analyst jobs in Oregon?

For Clinical Variant Analyst jobs in Oregon, the most frequently searched job titles are:

What job categories do people searching Clinical Variant Analyst jobs in Oregon look for?

The top searched job categories for Clinical Variant Analyst jobs in Oregon are:

What cities in Oregon are hiring for Clinical Variant Analyst jobs?

Cities in Oregon with the most Clinical Variant Analyst job openings:

Clinical Variant Analyst jobs near you
Infographic showing various Clinical Variant Analyst job openings in Oregon as of August 2026, with employment types broken down into 91% Full Time, and 9% Part Time. Highlights an 94% In-person, and 6% Remote job distribution.

Senior Product Manager, Clinical Genomics

Natera

OR • On-site, Remote

$126K - $166K/yr

Full-time

Re-posted 27 days ago

Natera rating

7.7

Company rating: 7.7 out of 10

Based on 38 frontline employees who took The Breakroom Quiz

57th of 120 rated laboratories

Job description

Senior Product Manager, Clinical Genomics Engineering

Natera offers genetic risk assessment and diagnostic tests to patients through medical providers. The Clinical Genomics Engineering organization builds software that supports complex, regulated workflows spanning tertiary analysis workflows including variant  interpretation, clinical review, and reporting. As Natera scales across Women's Health, Oncology, and Organ Health, delivering  cohesive, reliable, and compliant software experiences is foundational to clinical quality and commercial success.

Natera is seeking a Senior Product Manager to define and drive strategy for core components of the Results, Interpretation, and Reporting (RIR) platform. This role is responsible for shaping scalable, compliant, and cohesive clinical software systems that support complex genomics workflows across multiple business units. The Lead PM will operate as a platform-level owner, ensuring long-term architectural soundness, regulatory robustness, and measurable clinical and operational outcomes.

Initial Focus and Scope Evolution

The Senior Product Manager will lead cross-functional alignment across engineering, clinical, quality, and downstream systems to ensure RIR components operate as a cohesive, scalable platform. This role will identify systemic gaps, resolve cross-team tradeoffs, and drive architectural and workflow decisions that support long-term growth and regulatory compliance.

This role will initially own one or more RIR software components or initiatives, with responsibility for defining long-term strategy, aligning cross-component workflows, and ensuring scalable architecture across user-facing applications, data contracts, and backend services. The Lead PM will drive strategic investment decisions, establish standards for usability and reliability, and ensure systems meet evolving clinical, operational, and regulatory requirements.

As business needs evolve, this role will expand to influence and coordinate across multiple RIR components, driving cohesive workflow design, shared data standards, and platform-level scalability across Women's Health, Oncology, and Organ Health.

Primary Responsibilities

  • Define and drive multi-year product strategy and roadmap across one or more RIR components, ensuring alignment to clinical quality, regulatory requirements, and commercial scale objectives

  • Influence platform-level technical direction in partnership with engineering leadership 

  • Partner closely with software engineering, bioinformatics, clinical domain experts, quality, regulatory, and other product teams

  • Translate business, clinical, and operational needs into clear, actionable product requirements

  • Define and evolve end-to-end user workflows, including UI/UX requirements and supporting backend functionality

  • Drive cross-team alignment on shared data contracts and workflow standards

  • Mentor and raise the bar for product management within the RIR organization

  • Own measurable improvements in clinical workflow efficiency, reliability, and operational scalability

  • Establish prioritization frameworks that balance regulatory risk, clinical impact, technical scalability, and business outcomes across RIR investments.

  • Develop and track quantitative metrics related to usability, performance, reliability, and adoption

  • Lead delivery teams with clear strategic direction, ensuring requirements reflect long-term platform goals, validation readiness, and system interoperability.

  • Proactively identify systemic risks, architectural constraints, and workflow inefficiencies that may limit scale or regulatory robustness, and lead cross-functional initiatives to resolve them

  • Partner with Quality and Regulatory leadership to shape validation strategy, risk classification, traceability, and audit readiness for RIR software systems.

  • Create clear, data-driven written proposals and presentations to support stakeholder alignment and decision-making

  • Act as a subject matter expert for owned components, supporting design, testing, validation, rollout, and ongoing use

QualificationsRequired

  • Bachelor's degree in life sciences, engineering, computer science, statistics, or equivalent experience

  • 5+ years of experience in software product management, including ownership of complex, multi-team or platform-level initiatives

  • 5+ years experience working on production software in healthcare, clinical genomics, or other regulated lifesciences domains, with demonstrated impact on validation, compliance, and system scalability

  • Demonstrated experience influencing engineering architecture and long-term technical investment decisions

  • Proven ability to drive alignment across highly matrixed organizations without direct authority
    Track record of independently operating in ambiguous environments and establishing product direction

Preferred

  • Experience with clinical genomics and variant processing and interpretation workflows

  • Experience owning user-facing applications, tools, or operational software

  • Familiarity working with backend services, APIs, or data-driven systems

Knowledge, Skills, and Abilities

  • Ability to operate effectively at both tactical and strategic levels, connecting detailed execution to broader platform vision.

  • Strong analytical skills with attention to quality, reliability, and user outcomes

  • Leads technical design discussions and critically evaluates architectural tradeoffs to ensure scalability, reliability, and regulatory integrity

  • Proven ability to influence without authority and drive alignment across teams

  • Clear, concise written and verbal communication skills across technical and non-technical audiences

  • Ability to manage multiple initiatives in a fast-paced, regulated environment

  • Familiarity with Next Generation Sequencing concepts is beneficial

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