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Clinical Tmf Jobs (NOW HIRING)

Ocugen Inc

TMF Lead

Malvern, PA · On-site

$32.75 - $45/hr

Lead and own TMF activities across assigned clinical studies from study startup through closeout and archival, ensuring TMF completeness, quality, and continuous inspection readiness at every phase ...

Ocugen Opco Inc

TMF Lead

Malvern, AR · On-site

$120 - $180/hr

ResponsibilitiesLead and own TMF activities across assigned clinical studies from study startup through closeout and archival, ensuring TMF completeness, quality, and continuous inspection readiness ...

OCUGEN OPCO INC

TMF Lead

Malvern, PA · On-site

$32.75 - $45/hr

Lead and own TMF activities across assigned clinical studies from study startup through closeout and archival, ensuring TMF completeness, quality, and continuous inspection readiness at every phase ...

SolCur

WI · On-site

$60 - $75/hr

This role works closely with Clinical Operations, Study Management, Regulatory Affairs, Quality ... The TMF Associate plays a key role in maintaining inspection readiness and supporting the overall ...

New

Ergclinical

$60 - $85/hr

Familiarity with Good Clinical Practices (GCP), ICH guidelines, and the DIA TMF Reference Model is desirable. SKILLS and/or ABILITIES * Knowledge of regulatory requirements for clinical research ...

New

Praxis Precision Medicines, Inc.

TMF Operations Lead

OR · On-site +1

$33.50 - $45.75/hr

As our Trial Master File expert, you'll partner with Clinical Operations and cross-functional teams to build high-quality TMFs, identify and address risks early, and help ensure our studies are ...

Praxis Precision Medicines, Inc.

TMF Operations Lead

$99K - $119K/yr

As our Trial Master File expert, you'll partner with Clinical Operations and cross-functional teams to build high-quality TMFs, identify and address risks early, and help ensure our studies are ...

BridgeBio Pharma

Associate Director, TMF Operations Lead

$34.25 - $46.75/hr

This individual will establish and lead the TMF strategy across the BBP-418 clinical development program, ensuring inspection readiness through proactive oversight, quality management, and cross ...

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Clinical Tmf information

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$17

$39

$70

How much do clinical tmf jobs pay per hour?

As of Sep 3, 2026, the average hourly pay for clinical tmf in the United States is $39.99, according to ZipRecruiter salary data. Most workers in this role earn between $32.21 and $43.99 per hour, depending on experience, location, and employer.

What is a clinical TMF?

A Clinical TMF, or Trial Master File, is a collection of essential documents that are used in clinical trials to demonstrate compliance with regulatory requirements and Good Clinical Practice (GCP) guidelines. It includes all documents related to the planning, conduct, and management of a clinical study. Maintaining an accurate and complete TMF is crucial for ensuring the integrity of the trial and for audits by regulatory authorities. The TMF can be maintained in paper, electronic, or hybrid formats, and is typically managed by Clinical TMF Specialists or teams within pharmaceutical or clinical research organizations.

What are the key skills and qualifications needed to thrive as a clinical TMF specialist, and why are they important?

To thrive as a Clinical TMF Specialist, you need strong organizational skills, attention to detail, and a solid understanding of clinical trial documentation and regulatory requirements, often supported by a degree in life sciences or a related field. Familiarity with electronic Trial Master File (eTMF) systems, document management software, and Good Clinical Practice (GCP) guidelines is typically required. Excellent communication, problem-solving abilities, and the capacity to work independently make candidates stand out in this role. These skills ensure accurate documentation, compliance with regulatory standards, and smooth clinical trial operations.

What are some common challenges faced by clinical TMF professionals, and how can they be managed?

Clinical TMF (Trial Master File) professionals often encounter challenges related to maintaining TMF completeness, ensuring document accuracy, and meeting strict regulatory timelines. Coordinating with multiple stakeholders—such as clinical operations, quality assurance, and external vendors—requires strong organizational and communication skills. Proactively implementing robust tracking systems, conducting regular quality control checks, and fostering a culture of continuous training can help manage these challenges effectively and ensure compliance with industry standards.

What is the difference between Clinical Tmf vs Clinical Data Manager?

AspectClinical TmfClinical Data Manager
CredentialsTypically requires life sciences degree, TMF-specific trainingRequires degree in life sciences, biostatistics, or related field, often with data management certifications
Work EnvironmentWorks closely with clinical trial documentation, regulatory teamsFocuses on data collection, validation, and database management
Industry UsageUsed in clinical trial documentation and regulatory complianceUsed in data collection, cleaning, and analysis in clinical research

While both roles are essential in clinical research, Clinical Tmf specialists focus on managing trial documentation and regulatory files, whereas Clinical Data Managers handle data collection and analysis. Understanding these differences helps in choosing the right career path or job search focus.

More about Clinical Tmf jobs

What job categories do people searching Clinical Tmf jobs look for?

The top searched job categories for Clinical Tmf jobs are:

Infographic showing various Clinical Tmf job openings in the United States as of August 2026, with employment types broken down into 3% As Needed, 71% Full Time, 18% Part Time, and 8% Contract. Highlights an 95% Physical, 1% Hybrid, and 4% Remote job distribution, with an average salary of $83,169 per year, or $40 per hour.

Clinical Document Management Specialist

Integrated Resources INC

Lexington, MA • On-site

$39 - $52.50/hr

Contractor

Re-posted 19 days ago

Job description

Company Description

A Few Words About Us Integrated Resources, Inc is a premier staffing firm recognized as one of the tri-states most well-respected professional specialty firms. IRI has built its reputation on excellent service and integrity since its inception in 1996. Our mission centers on delivering only the best quality talent, the first time and every time. We provide quality resources in four specialty areas: Information Technology (IT), Clinical Research, Rehabilitation Therapy and Nursing.


This is Contract position with my direct client 

Job Description

Reporting to the Clinical Documentation Team Lead, and working in collaboration with the clinical study teams, the Clinical Document Management Specialist (CDMS) is responsible for the management and oversight of Trial Master File (TMF) records from set-up through to final archival of the clinical trial, ensuring compliance with company SOPs and processes, and all applicable regulations.

Focusing on inspection readiness, monitors compliance of the TMF and supports preparation of documentation required for regulatory agency inspections and internal audits.

Oversees set-up and consolidation of outsourced elements of the TMF with preferred CRO vendors. With support from the management team, performs periodic quality assessments of clinical TMF documents where required.

Contributes to assigned Clinical Document Management (CDM) initiatives.

Responsibilities

% of Time Job Function and Description

70% Responsible for high quality clinical document deliverables across multiple, global assigned studies in support of GCDO ensuring effective lifecycle management of the clinical section of the TMF.

Key contributor and member of the clinical study team

Monitors completeness and quality of the Clinical TMF, including elements outsourced to CRO

Ensures effective communication and issue escalation internally and with external vendors

Oversees consolidation and archive preparation of clinical TMF, liaising with CRO partners to ensure compliance with company SOPs and timelines throughout the process.

Ensures compilation of CSR appendices in accordance with Shire's process

20% Supports inspection readiness for GCDO through periodic quality assessment of clinical records.

Ensures clinical records are filed in a timely manner

With direction from the CDM Manager, prepares clinical records for agency inspection.

Supports assigned TMF corrective action plans under direction of Senior CDM/Manager.

10% Supports CDM initiatives to enhance efficiencies in document management practices

Qualifications

Education and Experience Requirements

Minimum 2 years of pharmaceutical industry experience

Records management/TMF experience

Familiarity with various aspects of clinical trials and regulatory submissions. Current awareness of regulatory requirements for clinical trials (ICH/GCP).

Associates/Bachelor's degree or equivalent preferred

Additional Information

Contact me at 732 429 1924

Integrated Resources logo

About Integrated Resources

Sourced by ZipRecruiter

Integrated Resources Inc (IRI), based in Edison, NJ, US, is an esteemed player in the staffing solutions industry with a credible presence on their official website irionline.com. Notably, IRI provides a range of professional staffing services including contract, contract-to-hire, and direct hire solutions to a wide spectrum of industries such as healthcare, life sciences, manufacturing, financial, insurance, and others. Since its inception, IRI has been committed to delivering top-talent and optimum solutions to meet its clients' diverse needs.

Industry

Recruiting and staffing services

Company size

51 - 200 Employees

Headquarters location

Edison, NJ, US

Year founded

1996

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