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Clinical Operation Manager Jobs in Silver Spring, MD

Ambu

Clinical Data Manager

Columbia, MD · On-site

Serve as the primary operational liaison between clinical sites, investigators, internal stakeholders, and external vendors. * Support study budgets, contracts, site agreements, and vendor management ...

WizeHire, Inc

Clinical Operations Lead

Fairfax, VA · On-site

$90 - $120/hr

Role Overview This role is roughly: * 50-70% clinical : intakes, education, follow‑ups, side‑effect management, tougher situations. * 30-50% operational : overseeing day‑to‑day clinic flow ...

REGENXBIO

Sr Clinical Project Manager

Rockville, MD · On-site

The Sr. CPM provides operational leadership to the clinical operations team to ensure project ... This position may include line management responsibilities and will also be able and willing to ...

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Showing results 21-40

All JobsClinical Operation JobsClinical Operation Manager JobsClinical Operation Manager Jobs in Silver Spring, MD

Clinical Operation Manager information

See Silver Spring, MD salary details

$36.2K

$101.3K

$192.8K

How much do clinical operation manager jobs pay per year?

As of Aug 22, 2026, the average yearly pay for clinical operation manager in Silver Spring, MD is $101,350.00, according to ZipRecruiter salary data. Most workers in this role earn between $74,900.00 and $117,300.00 per year, depending on experience, location, and employer.

What is a clinical operation manager?

Clinical Operation Managers are professionals responsible for overseeing the daily operations of clinical research sites, medical facilities, or departments. They ensure that clinical trials or healthcare services are conducted efficiently, comply with regulations, and meet quality standards. Their duties often include supervising staff, managing budgets, implementing policies, and coordinating between various teams. Clinical Operation Managers play a crucial role in ensuring that patient care and research activities run smoothly and effectively.

What are the key skills and qualifications needed to thrive as a clinical operation manager?

To thrive as a Clinical Operation Manager, you need expertise in clinical project management, regulatory compliance, and a background in healthcare or life sciences, often supported by a relevant degree. Familiarity with clinical trial management systems (CTMS), electronic data capture (EDC) tools, and certifications such as PMP or Six Sigma are commonly required. Strong leadership, problem-solving abilities, and excellent communication skills set top performers apart in this role. These competencies are essential for ensuring efficient clinical operations, maintaining regulatory standards, and leading teams to deliver successful trial outcomes.

What are some common challenges clinical operation managers face when coordinating multi-site clinical trials?

Clinical Operation Managers often encounter challenges such as ensuring consistent protocol adherence across all sites, managing communication among geographically dispersed teams, and maintaining timelines despite unexpected delays. They must also address regulatory differences between sites and troubleshoot issues related to patient recruitment and data collection. Success in this role requires strong organizational skills, adaptability, and effective collaboration with investigators, coordinators, and regulatory personnel.

What is the difference between Clinical Operation Manager vs Clinical Research Coordinator?

AspectClinical Operation ManagerClinical Research Coordinator
CredentialsBachelor's degree in health sciences, life sciences, or related field; often with project management certificationsBachelor's degree in health sciences, nursing, or related field; often with research-specific training
Work EnvironmentOversees multiple clinical trials, manages teams, and ensures compliance at a departmental levelCoordinates daily activities of clinical trials, interacts directly with participants and investigators
Employer & IndustryPharmaceutical companies, biotech firms, hospitals, research institutionsResearch sites, hospitals, academic institutions, contract research organizations

The Clinical Operation Manager focuses on overseeing clinical trial operations, managing teams, and ensuring compliance across projects. In contrast, the Clinical Research Coordinator handles the day-to-day activities of specific trials, working closely with participants and investigators. Both roles require relevant healthcare or science credentials, but their scope and responsibilities differ significantly.

What are popular job titles related to Clinical Operation Manager jobs in Silver Spring, MD?

For Clinical Operation Manager jobs in Silver Spring, MD, the most frequently searched job titles are:

What job categories do people searching Clinical Operation Manager jobs in Silver Spring, MD look for?

The top searched job categories for Clinical Operation Manager jobs in Silver Spring, MD are:

What cities near Silver Spring, MD are hiring for Clinical Operation Manager jobs?

Cities near Silver Spring, MD with the most Clinical Operation Manager job openings:

Clinical Operation Manager jobs near you
Infographic showing various Clinical Operation Manager job openings in Silver Spring, MD as of August 2026, with employment types broken down into 90% Full Time, 9% Part Time, and 1% Contract. Highlights an 81% Physical, 2% Hybrid, and 17% Remote job distribution, with an average salary of $101,350 per year, or $48.7 per hour.

Sr. Clinical Operations Lead (Clinical Trial Manager)

Alimentiv

Washington, DC • Remote

$86K - $143K/yr

Full-time

Re-posted 4 days ago

Job description

Responsible for the clinical operations of a project within a defined regional/global level.  Provides oversight of project deliverables, assigned Clinical Research Associate (CRAs) and Investigator sites in accordance with the Monitoring Plan, Protocol, Good Clinical Practice (GCP), ICH guidelines and local regulations.  The COL acts as a primary liaison between the CRAs and the clinical project team.  Additional responsibilities include project specific training of CRAs, conducting assessment visits with CRAs, implementation of enrollment and recruitment strategies, preparation of the monitoring plan and other structural documentation and the oversight of monitoring visit scheduling, site and monitoring performance metrics, issue escalation and corrective actions.  The COL will develop study tools for site and CRA use, review visit reports, review and track protocol deviations, and support other objectives for clinical operations and the clinical project team.
Project Oversight
  • Overall oversight of (a group of) regional CRAs to ensure (site) compliance with study protocol, study plans, ICH-GCP, local regulations and study timelines.
  • Monitoring support visits (Co-monitoring), per project requirements, to aid the site/CRA in the satisfactory performance and compliance with standards mentioned above.
  • May support clinical project team by providing oversight of study deliverables related to other departments (e.g. Data Management, TMF Operations, etc.)
  • Oversee regional startup and feasibility activities.
  • Assist in vendor management activities as required per project.
  • Perform review of visit reports for quality, compliance and appropriate site management.
  • Assure compliance with high quality and timely project deliverables according to the project requirements and the monitoring plan.
  • Proactive management of site and country performance (recruitment, data collection, document collection, TMF review etc.) and inform clinical project team on progress.
  • Contribute to financial project management processes as applicable.  May include but may not be limited to input on revenue recognition, site payments, and site pass-through expense review.
  • May be required to manage/oversee investigator sites including CRA responsibilities, on a temporary or permanent basis.         
Project Liaison
  • Conduct regular global CRA calls with the monitoring and site management team, as well as individual/country CRA calls 
  • Attend meetings with Study Sponsor to provide status updates on country and site progress
  • Provide operational support and guidance to the monitoring team throughout project.
  • Provide project training/mentoring to regional CRAs on study procedures, clinical plans and guidelines, and timelines for the study. Ensures study specific training requirements are completed and documented.
  • First point of contact for regional CRAs for study-specific questions and issues. Escalates to PM and other functions as appropriate.
  • Support line managers by providing status updates on utilization and performance of CRAs. 
  • Liaise with line manager for assigning sites to CRAs following line manager allocation of a CRA resource to the project. 
  • Conduct CRA Assessment visits per departmental requirements to assess the performance of the CRA against their monitoring responsibilities.
Study Documents and Plans
  • Develop training materials and study tools for sites and CRAs, including monitoring plans.
  • Develop and implement enrolment and recruitment strategies together with clinical project team.
  • Develop presentation materials for and presents at Sponsor Kickoff meetings, Investigator meetings and Sponsor Calls (as needed), and prepares presentations for Site Qualification Visits and Site Initiation Visits.
 
Qualifications
  • College diploma/degree AND 7-9 years related experience +continuous training and knowledge/skills upgrading
OR
  • Undergraduate university degree (Bachelors or Honors Bachelors) AND 4-6 years' experience + substantial on-going job-related training
Other
  • Health Sciences, Life Sciences or Nursing specialty preferred, or SoCRA and/or ACRP Certification/Designation.
  • Should have a minimum of 3 years CRA experience, have strong experience with EDC systems, be proficient with MS Office, have strong written and verbal communication skills and highly effective interpersonal and organizational skills.
  • Demonstrate the following attributes: proactive, detail oriented, task-driven and highly organized.
  • Demonstrate the critical elements of GCPs and local regulations as they relate to clinical monitoring, IRB/EC and Investigator responsibilities.
  • Demonstrated ability in report writing and strong ability to critically understand clinical research documents.
  • Ability to handle multiple tasks to meet deadlines in a dynamic environment. 
 
Working Conditions
  • Home-based
+ Bonus
Accommodations for persons with disabilities are available on request in respect of all aspects of the recruitment and selection lifecycle. Requests can be directed to recruitment@alimentiv.com
 
PHISHING SCAM WARNING: Alimentiv is aware of the continued increase of phishing scams, leveraging various methods of attack via email, text, voice and social media. Please note that Alimentiv only uses company email addresses, which contain “@alimentiv.com”, to communicate with candidates via email. If you are contacted by someone about an open job at Alimentiv, please verify the domain of the sender’s email address and that they are asking you to apply on this website. If you believe you’ve been a victim of a phishing scam, please contact your local government cyber authority to report.
 

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.