Biologist - Purification Scientist
Client: Eli Lilly and Company
Location: Boston, MA (Onsite)
Schedule: Monday–Friday | 8:00 AM–5:00 PM (40 hrs/week
Position Summary
Seeking an early-career Biologist / Purification Scientist to join the Downstream Process Development team in Boston, MA. This role will support purification and characterization of viral vectors, biologics, or recombinant proteins for process development and manufacturing activities. The ideal candidate has hands-on laboratory experience with chromatography-based purification techniques and strong documentation and collaboration skills.
Key Responsibilities
Execute purification processes including affinity chromatography (e.g., AVB, CaptureSelect), ion-exchange chromatography (AEX, CEX), and polishing steps
Operate AKTA systems (Avant, Pure, Pilot) for small- to large-scale purification runs
Perform tangential flow filtration (TFF) for buffer exchange and product concentration
Prepare buffers and manage chromatography columns and consumables
Support experimental design, data collection, and detailed documentation in accordance with GMP/GLP practices
Assist with troubleshooting and optimization of purification processes
Analyze samples using standard analytical techniques (e.g., UV, SDS-PAGE, ELISA, ddPCR, HPLC)
Collaborate with upstream process, analytical, and manufacturing teams
Maintain laboratory equipment and ensure compliance with safety and quality standards
Required Qualifications
Master’s degree in Biochemistry, Biotechnology, Chemical Engineering, or a related scientific discipline
Minimum 2 years of hands-on purification experience in an academic or industry laboratory
Practical experience with ion-exchange and affinity chromatography
Experience with buffer preparation and basic analytical characterization methods
Strong attention to detail with excellent documentation practices
Ability to manage multiple tasks and meet project timelines
Effective written and verbal communication skills
Preferred Qualifications
Experience with AAV or other viral vector purification
Hands-on experience with AKTA systems and Unicorn software
Exposure to downstream process development or biomanufacturing environments