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Biophysical Chemistry Jobs (NOW HIRING)

System One

Analytical Chemist II

Pearl River, NY · On-site

$27 - $33.14/hr

Bachelor's degree in chemistry, Biochemistry, Biology, Biophysics, or another Life Sciences discipline with 2+ years of relevant experience; OR Master's degree in a related scientific discipline with ...

System One

Analytical Chemist II

Pearl River, NY · On-site

$27 - $33.14/hr

Bachelor's degree in chemistry, Biochemistry, Biology, Biophysics, or another Life Sciences discipline with 2+ years of relevant experience; OR Master's degree in a related scientific discipline with ...

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Biophysical Chemistry information

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$20.5K

$90.6K

$155.5K

How much do biophysical chemistry jobs pay per year?

As of Aug 9, 2026, the average yearly pay for biophysical chemistry in the United States is $90,649.00, according to ZipRecruiter salary data. Most workers in this role earn between $69,000.00 and $112,000.00 per year, depending on experience, location, and employer.

What are the typical daily responsibilities of someone working in biophysical chemistry?

A professional in biophysical chemistry typically spends their day conducting experimental research, analyzing data using specialized instruments, and collaborating closely with colleagues from fields such as biology, physics, and computational science. Daily tasks include designing experiments, interpreting molecular interactions, preparing detailed reports, and presenting findings to stakeholders or at scientific meetings. You may also be involved in troubleshooting equipment and staying updated on the latest advancements in biophysical techniques. This dynamic environment offers ongoing opportunities to refine one's expertise and contribute to breakthroughs in medical, pharmaceutical, or materials science applications.

What are the key skills and qualifications needed to thrive in biophysical chemistry?

To thrive in biophysical chemistry, you typically need a strong background in chemistry, physics, and mathematics, usually supported by at least a bachelor's or master's degree in chemistry, biochemistry, or a related field. Proficiency in analytical instruments such as NMR spectroscopy, mass spectrometry, and computational modeling software is commonly required. Critical thinking, problem-solving, and effective communication are important soft skills for collaborating with multidisciplinary teams and presenting research findings. These combined skills enable biophysical chemists to investigate complex biological systems and contribute to scientific advancements.

What is biophysical chemistry?

A Biophysical Chemistry job involves studying the physical principles that govern biological molecules and systems. Professionals in this field use techniques from physics and chemistry to analyze biomolecular structures, interactions, and functions. They often work in research laboratories, pharmaceutical companies, or academia to develop new drugs, study protein folding, or understand cellular processes.

What does a biophysical chemist do?

A biophysical chemist studies the physical principles underlying biological molecules and systems, often using techniques like spectroscopy, microscopy, and computational modeling. They analyze the structure, dynamics, and interactions of biomolecules to understand biological processes and develop new applications in medicine, biotechnology, or materials science.
More about Biophysical Chemistry jobs
What states have the most Biophysical Chemistry jobs? States with the most job openings for Biophysical Chemistry jobs include:
What job categories do people searching Biophysical Chemistry jobs look for? The top searched job categories for Biophysical Chemistry jobs are:
Biophysical Chemistry jobs near you
Infographic showing various Biophysical Chemistry job openings in the United States as of August 2026, with employment types broken down into 1% Internship, 69% Full Time, 25% Part Time, 1% Temporary, and 4% Contract. Highlights an 83% Physical, 1% Hybrid, and 16% Remote job distribution, with an average salary of $90,649 per year, or $43.6 per hour.

Director, Medicinal Chemistry

Eli Lilly and Company

Louisville, CO • On-site

$163K - $257K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 20 days ago

Eli Lilly and Company rating

8.8

Company rating: 8.8 out of 10

Based on 63 frontline employees who took The Breakroom Quiz

11th of 86 rated pharmaceutical

Job description

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work-but it's work worth doing. If you're driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.
Overview
  • Lilly's Early Molecule Discovery team drives small-molecule hit identification and hit-to-lead progression through structure-based, mechanism-informed, and data-driven design.

  • We are seeking a hands-on medicinal chemistry leader with direct experience advancing molecular glue programs, from hit finding through candidate selection.

  • The role requires close collaboration across pharmacology, structural biology, computational chemistry, and DMPK to translate mechanistic hypotheses into optimized molecules.

  • Success requires both deep bench-level chemistry expertise and the interpersonal and cross-functional leadership skills to guide internal and external teams.

Responsibilities
  • Lead hit-to-lead optimization of screening hits, improving potency, selectivity, physicochemical properties, and ADMET.

  • Apply structure-based and data-driven design, incorporating ternary complex structural data where relevant.

  • Design and synthesize novel molecules to test mechanistic hypotheses, including cooperativity-driven SAR for molecular glue chemotypes.

  • Design and implement screening cascades tailored to molecular glue pharmacology.

  • Direct internal and external medicinal chemistry resources, including CRO relationships, to keep programs aligned with strategy and timelines.

  • Oversee high-throughput synthesis, route scouting, and scale-up to enable efficient compound delivery.

  • Maintain a strong safety culture and efficient lab operations.

Basic Qualifications
  • PhD in Organic Chemistry or related Chemistry field with 8+ years of relevant experience in small molecule drug discovery; MS with 10+ years; or BS with 12+ years.

Preferred Skills and Experience
  • Extensive experience in medicinal chemistry, SAR analysis, and structure- and mechanism-based molecular design.
  • Direct experience designing or optimizing molecular glue degraders, including protein-protein interface engagement, E3 ligase biology, and neosubstrate identification.

  • Demonstrated leadership as a chemistry lead on programs of any mechanism-ideally including a molecular glue program-that reached candidate selection.

  • Track record of scientific contributions through publications, patents, or external presentations.

  • Experience managing or collaborating with external chemistry teams and CROs.

  • Experience with novel modalities, such as targeted protein degradation and covalent chemistry, and biophysical techniques to mechanistically understand molecular glue SAR.

  • Familiarity with computational drug design tools (e.g., LiveDesign, MOE, Maestro) and AI-enabled chemistry tools.

  • Self-driven, with a growth mindset and adaptability to fast-evolving science.

  • Strong communication and collaboration skills in multidisciplinary, matrixed environments.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women's Initiative for Leading at Lilly (WILL).
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$163,500 - $257,400
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
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About Eli Lilly

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Eli Lilly, based in Indianapolis, IN, US, is one of the pioneers in the pharmaceutical industry with a rich history dating back to 1876. This global pharmaceutical company focuses on discovering, developing, manufacturing and selling pharmaceutical products in approximately 120 countries. The company's product categories include endocrinology, oncology, cardiovascular, neuroscience, and immunology. Having invested over $9 billion in research and development in the past decade, Eli Lilly is also committed to creating high-quality medicines that meet real needs. As a recipient of several awards and recognitions, Eli Lilly is known for its focus on life-saving research and drug development. Their mission is to make medicines that help people live longer, healthier, and more active lives.

Industry

Pharmaceutical product wholesalers

Company size

10,000+ Employees

Headquarters location

Indianapolis, IN, US

Year founded

1876

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