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Nmr Structure Biology Biophysics Jobs (NOW HIRING)

University of Colorado

Post-Doctoral Fellow

Aurora, CO · On-site

$49K - $67K/yr

Solution NMR spectroscopy (structure, dynamics) * Cryo-EM of large macromolecular assemblies ... structural biology, biophysics, or a related field * Strong experience in biomolecular NMR ...

University of Colorado

Post-Doctoral Fellow

Aurora, CO

$49K - $67K/yr

Solution NMR spectroscopy (structure, dynamics) * Cryo-EM of large macromolecular assemblies ... structural biology, biophysics, or a related field * Strong experience in biomolecular NMR ...

Output Biosciences

Head of Biology

New York, NY · On-site

You have a PhD in computational biology, biophysics, structural biology, molecular biology, or a ... You have structural biology expertise, including protein structure analysis and structure-function ...

Namely

Head of Biology

Manhattan, NY · On-site

$90 - $120/hr

You have a PhD in computational biology, biophysics, structural biology, molecular biology, or a ... You have structural biology expertise, including protein structure analysis and structure-function ...

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Nmr Structure Biology Biophysics information

What is NMR Structure Biology Biophysics?

NMR Structure Biology Biophysics is a scientific field that uses Nuclear Magnetic Resonance (NMR) spectroscopy to study the structures, dynamics, and interactions of biological molecules like proteins and nucleic acids. Researchers in this field use principles of biophysics to interpret NMR data and gain insights into how biomolecules function at the molecular level. This approach is essential for understanding biological processes, drug design, and protein engineering, as it provides detailed information about molecular structure and interactions in solution.

What are the key skills and qualifications needed to thrive as an NMR Structural Biology Biophysicist, and why are they important?

To excel as an NMR Structural Biology Biophysicist, you need a solid background in biochemistry, molecular biology, and physics, typically with a PhD and experience in structural analysis. Proficiency with NMR spectrometers, data processing software (such as TopSpin or NMRPipe), and familiarity with related bioinformatics tools is essential. Strong analytical thinking, attention to detail, and effective collaboration are crucial soft skills in this field. These competencies are vital for accurately determining biomolecular structures and contributing meaningful insights to interdisciplinary research projects.

What are some common challenges faced by NMR Structure Biology Biophysics professionals in interpreting experimental data?

Professionals in NMR Structure Biology Biophysics often encounter challenges such as spectral overlap, sample instability, and low sensitivity, which can complicate data interpretation. Dealing with large or complex biomolecules may require advanced techniques and significant computational analysis to accurately assign resonances and determine structures. Collaborating closely with chemistry, bioinformatics, and structural biology teams is essential to overcome these challenges and ensure reliable results. Staying current with software and hardware advancements can also aid in addressing these common obstacles.

What is the difference between Nmr Structure Biology Biophysics vs Nmr Spectroscopist?

AspectNmr Structure Biology BiophysicsNmr Spectroscopist
Required CredentialsAdvanced degrees in biology, biochemistry, or biophysics; specialized NMR trainingDegree in chemistry, physics, or related field; NMR certification often preferred
Work EnvironmentResearch labs, academic institutions, biotech companiesResearch labs, pharmaceutical companies, academic settings
Industry UsageFocus on understanding biological structures and functionsFocus on NMR technique development and spectral analysis

While both roles involve NMR techniques, Nmr Structure Biology Biophysics emphasizes studying biological molecules' structures and functions, whereas Nmr Spectroscopist specializes in spectral data acquisition and analysis. The former is more biology-oriented, and the latter leans toward chemistry and physics applications.

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Nmr Structure Biology Biophysics jobs near you
Infographic showing various Nmr Structure Biology Biophysics job openings in the United States as of August 2026, with employment types broken down into 1% Internship, 86% Full Time, 10% Part Time, and 3% Contract. Highlights an 54% Physical, 2% Hybrid, and 44% Remote job distribution.

Scientist-Principal Scientist, Protein Design & Structure

Superluminal Medicines, Inc.

Boston, MA • On-site

Full-time

Re-posted 4 days ago

Job description

Position Summary

We are seeking a highly innovative and experienced Scientist/Senior Scientist/Principal Scientist to lead GPCR protein engineering and production efforts. The successful candidate will be a subject matter expert (SME) in membrane protein biochemistry, responsible for developing and implementing strategies to express, purify, and characterize challenging G-protein coupled receptors (GPCRs) to support structural biology, biophysics, and drug discovery programs. This role involves hands-on laboratory work and scientific leadership. 

Key Responsibilities

  • Protein Engineering Strategy: Design, execute, and optimize constructs for GPCR expression.
  • Expression & Purification: Drive the development of high-throughput protein expression (mammalian/insect cells) and purification workflows, ensuring high-quality, homogeneous protein for assays and structural studies (Cryo-EM).
  • Cross-Functional Collaboration: Partner with pharmacology, structural biology, and medicinal chemistry teams to support drug discovery projects and advance programs from hit-to-lead and lead optimization.
  • Technical Leadership: Serve as a SME on GPCR protein sciences in internal and external project teams; evaluate and implement new technologies.
  • Scientific Documentation & Communication: Document experiments in ELN, present data at internal/external meetings, and publish research findings.

Required Qualifications

  • Ph.D. in Biochemistry, Molecular Biology, Biophysics, or a related field with 2+ years (Scientist), 5+ years (Senior Scientist), or 8+ years (Principal Scientist) of relevant experience; or a master's or bachelor's degree in a related field with commensurate industry experience. 
  • Deep knowledge of GPCR biology and membrane protein structure-function relationships.
  • Proven expertise in molecular biology (cloning, construct design, mutagenesis).
  • Hands-on experience in protein purification of GPCRs using FPLC (affinity, SEC).
  • Familiarity with protein stabilization techniques (e.g., antibody fragments, fusion partners, mutagenesis).
  • Excellent communication, interpersonal, and leadership skills.

Preferred Qualifications

  • Experience with structural biology methods (data collection and processing for Cryo-EM).
  • Experience in laboratory automation in protein sciences & purification.
  • Background in computational protein design tools (e.g., Rosetta, AI/ML-driven prediction).

Apply