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Assistant System Engineer Jobs in California (NOW HIRING)

The Rockridge Group

Systems Engineer

Pleasanton, CA

Managed IT Service Manager The System Engineer is responsible for the maintenance and improvement ... Ability to speak with C-Level Management and assist in the creation of business technology roadmaps

BTAS

Senior Comp/Network System Engineer

El Segundo, CA · On-site

$183K - $300K/hr

Senior Comp/Network System Engineer LOCATION: El Segundo, CA/Flexible REQUIRED SECURITY CLEARANCE ... Advise and assist on cost, schedule, and performance issues. * Revise or draft Joint Capabilities ...

AMERICAN SYSTEMS

$133K - $222K/yr

Analyze system requirements and design solutions to enhance air and maritime surveillance ... Support development, modification, and maintenance of AMOSS software and interfaces * Assist with ...

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All JobsSystem Engineer JobsAssistant System Engineer JobsAssistant System Engineer Jobs in California

Assistant System Engineer information

See California salary details

$32.6K

$87.6K

$132.7K

How much do assistant system engineer jobs pay per year?

As of Aug 9, 2026, the average yearly pay for assistant system engineer in California is $87,592.00, according to ZipRecruiter salary data. Most workers in this role earn between $69,600.00 and $103,100.00 per year, depending on experience, location, and employer.

What are some common challenges faced by assistant system engineers during the onboarding period?

Assistant System Engineers often encounter challenges such as quickly adapting to complex IT infrastructures, learning proprietary systems, and understanding organization-specific protocols. Collaborating with senior engineers and cross-functional teams can also require strong communication skills to bridge knowledge gaps. Proactively seeking guidance, participating in training sessions, and utilizing available documentation are effective ways to overcome these initial hurdles and build a solid technical foundation.

What is the difference between Assistant System Engineer vs System Engineer?

AspectAssistant System EngineerSystem Engineer
QualificationsBachelor's degree in Computer Science or related field, certifications like CompTIA or Cisco are commonSame as Assistant System Engineer, often with additional certifications or experience
Work EnvironmentSupportive roles in IT teams, assisting with system maintenance and troubleshootingDesign, implement, and manage complex IT systems and infrastructure
ResponsibilitiesAssist in system setup, monitoring, and basic troubleshootingLead system design, deployment, and optimization

In summary, Assistant System Engineers typically support and assist System Engineers in daily tasks, focusing on maintenance and troubleshooting, while System Engineers handle more complex system design and management responsibilities.

What is an assistant system engineer?

Assistant System Engineers are entry-level professionals who support the design, implementation, and maintenance of computer systems and networks within an organization. They assist senior engineers in troubleshooting technical issues, configuring hardware and software, and ensuring the smooth operation of IT infrastructure. This role provides hands-on experience and exposure to various technologies, making it a common starting point for a career in systems engineering.

What are the key skills and qualifications needed to thrive as an assistant system engineer, and why are they important?

To thrive as an Assistant System Engineer, you need a solid grounding in computer science fundamentals, troubleshooting, and system administration, typically supported by a relevant degree or certification. Familiarity with operating systems (such as Linux and Windows), scripting languages, and IT service management tools like ServiceNow is often required. Strong analytical thinking, effective communication, and teamwork skills set outstanding candidates apart in this role. These competencies enable efficient problem-solving and collaboration, ensuring reliable system performance and swift resolution of technical issues.
What are the most commonly searched types of System Engineer jobs in California? The most popular types of System Engineer jobs in California are:
What cities in California are hiring for Assistant System Engineer jobs? Cities in California with the most Assistant System Engineer job openings:
Assistant System Engineer jobs near you
Infographic showing various Assistant System Engineer job openings in California as of August 2026, with employment types broken down into 1% As Needed, 74% Full Time, 21% Part Time, 2% Temporary, and 2% Contract. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $87,592 per year, or $42.1 per hour.

Business System Engineer - Enterprise Applications

Rezolute

Redwood City, CA

$131K - $162K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 5 days ago

Job description

Rezolute is a late-stage rare disease biopharmaceutical company focused on developing transformative therapies for patients living with severe metabolic and endocrine disorders. Our lead investigational therapy, RZ358 (ersodetug), is a fully human monoclonal antibody in late-stage clinical development for the treatment of congenital and acquired forms of hyperinsulinism (HI). Rezolute's mission is to bring hope and meaningful solutions to patients and families affected by rare diseases through scientific innovation, collaboration, and integrity. 

The Business Systems Engineer - Enterprise Applications position is a hands-on technical contributor responsible for executing and supporting the implementation, integration, and optimization of enterprise and business systems across the organization.

This role bridges business stakeholders, vendors, and IT, ensuring systems are deployed effectively, align with operational needs, and adhere to compliance and validation standards. The Business Systems Engineer - Enterprise Applications works directly with technical environments and configurations-not just project coordination-to help bring systems online efficiently and correctly.

This individual collaborates closely with the Director of Quality Assurance- Computer Systems to ensure implementation activities align with validation requirements and reports to the Associate Director of IT, who oversees enterprise architecture, strategic planning, and IT roadmap execution.

The ideal candidate has experience in the biotech or pharmaceutical industry, particularly in organizations moving from clinical to commercial phases, and understands how to deliver systems that meet both business and compliance expectations.

Key Responsibilities:
  • Take a hands-on role in configuring, implementing, and supporting enterprise and business systems across departments.
  • Work with business stakeholders to capture requirements and translate them into technical and system configurations.
  • Lead cross-functional and IS/IT-centric projects, ensuring alignment between business stakeholders, vendors, and internal IT resources.
  • Collaborate with IT staff and external vendors to deploy, integrate, and optimize systems that support operational growth.
  • Partner with the CSV team to ensure implementation tasks align with validation processes, providing technical assistance (e.g., system setup, environment readiness, data preparation, and issue resolution).
  • Support and troubleshoot system integrations, user access issues, and environment dependencies within AWS and Azure ecosystems.
  • Participate in data migration and environment setup activities during system deployment.
  • Maintain detailed documentation of system configurations, workflows, and change controls.
  • Identify and escalate project risks, blockers, or dependencies to the Associate Director of IT.
  • Provide post-implementation support and assist in transitioning systems to steady-state ownership.
Qualifications:
  • Bachelor's degree in Information Technology, Computer Science, or a related discipline (or equivalent experience).
  • Minimum of 5  years of experience implementing or supporting enterprise and business systems in biotech or pharmaceutical organizations.
  • Hands-on experience with platforms such as Veeva Vault, ERP systems (e.g., NetSuite, SAP, or Oracle), and cloud environments (AWS and Azure).
  • Familiarity with GxP, SOX, and data integrity principles.
  • Understanding of both clinical-phase and commercial-phase biotech operations.
  • Strong troubleshooting, analytical, and documentation skills.
  • Ability to manage multiple priorities and adapt to evolving business needs.
  • Excellent communication skills and ability to work cross-functionally across IT, QA/CSV, and business teams.

Core Competencies

  

Hands-On Executor: Comfortable configuring, testing, and deploying systems directly.

Collaborative Partner: Works effectively with IT, CSV, and business stakeholders to drive compliant implementations.

Analytical Problem-Solver: Identifies technical challenges and implements scalable solutions.

Detail-Oriented: Maintains precision in documentation and configuration management.

Clear Communicator: Provides concise updates and transparent reporting to leadership.

Adaptable: Operates effectively in a fast-paced, evolving biotech environment.

Rezolute (RZLT) currently anticipates the base salary for the Business Systems Engineer - Enterprise Applications role could range from $120,000 to $160,000 and will depend, in part, on the successful candidate's geographical location and their qualifications for the role, including education and experience. This position will also be eligible for an annual performance bonus in accordance with the terms of the applicable plan (depending, in part, on company and individual performance and at the Company's discretion on an individual basis). The compensation described above is subject to change and could be higher or lower than the range described based on current market survey data and the qualifications, education, experience and geographical location of the selected candidate. Rezolute offers competitive compensation, stock options and a rich benefits package.

Qualifying employees are eligible to participate in benefit programs such as:

  • Health Insurance (Medical / Dental / Vision)
  • Disability, Life & Long-Term Care Insurance
  • Holiday Pay
  • Tracking Free Vacation Program
  • 401(k) Plan Match
  • Educational Assistance Benefit
  • Fitness Center Reimbursement

We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class.


We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
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