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GrapheneDx

Research Scientist, Assay Development

Boston, MA · On-site

$85K - $120K/yr

The Research Scientist in Assay Development will design and execute experiments to functionalize sensors with nucleic acid or antibody probes for biomarker detection, contributing to the development ...

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How much do assay development jobs pay per hour?

As of May 31, 2026, the average hourly pay for assay development in the United States is $38.66, according to ZipRecruiter salary data. Most workers in this role earn between $28.37 and $46.15 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in Assay Development, and why are they important?

To thrive in Assay Development, you need a solid background in biochemistry, molecular biology, or a related field, often supported by a relevant degree or advanced training. Familiarity with laboratory instrumentation, data analysis software, and validation protocols is typically required, along with experience in techniques like ELISA, PCR, or cell-based assays. Strong attention to detail, problem-solving abilities, and effective collaboration are crucial soft skills in this role. These competencies ensure the accuracy, reliability, and efficiency of assays, which are critical for research, diagnostics, and product development.

What are some common challenges faced when developing new assays, and how can they be addressed?

Assay Development professionals often encounter challenges such as optimizing assay sensitivity and specificity, troubleshooting inconsistent results, and adapting protocols for high-throughput environments. These issues are typically addressed through systematic optimization of reagents and conditions, rigorous validation, and collaboration with cross-functional teams like R&D, quality assurance, and automation specialists. Clear documentation and regular team meetings also help in quickly identifying and resolving technical hurdles, ensuring the assay meets project goals and regulatory standards.

What is assay development?

Assay development refers to the process of designing, optimizing, and validating analytical tests (assays) used to detect or measure specific substances, such as proteins, nucleic acids, or small molecules, within a sample. This work is crucial in fields like biotechnology, pharmaceuticals, and diagnostics, as it ensures that assays are accurate, reliable, and suitable for their intended applications. Professionals in assay development work on tailoring assay conditions, selecting appropriate detection methods, and establishing protocols to support research or clinical decision-making.

What is the difference between Assay Development vs Laboratory Scientist?

AspectAssay DevelopmentLaboratory Scientist
CredentialsBachelor's or Master's in Life Sciences, relevant certificationsBachelor's or Master's in Life Sciences, relevant certifications
Work EnvironmentResearch labs, biotech companies, pharmaceutical firmsResearch labs, hospitals, biotech companies
Industry UsageDesigning and optimizing assays for research and diagnosticsPerforming experiments, data collection, and analysis

Assay Development focuses on creating and optimizing diagnostic or research assays, while Laboratory Scientists perform experiments and analyze data within the lab. Both roles require similar educational backgrounds and often work in similar environments, but their core responsibilities differ in scope and focus.

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Assay Development jobs near you
Research Associate II/III, Assay Development (Contract)

Research Associate II/III, Assay Development (Contract)

Adverum Biotechnologies, Inc.

Redwood City, CA

$25 - $40/hr

Contractor

Posted 27 days ago

Job description

Adverum Biotechnologies, Inc., wholly owned subsidiary of Eli Lilly and Company, is a mission-driven clinical-stage company that aims to establish gene therapy as a new standard of care for highly prevalent ocular diseases with the aspiration of developing functional cures to restore vision and prevent blindness. Leveraging the research capabilities of its proprietary intravitreal (IVT) platform, Adverum is developing durable, single-administration therapies designed to be delivered in physicians' offices to eliminate the need for frequent ocular injections to treat these diseases. By overcoming the challenges associated with current treatment paradigms for these debilitating ocular diseases, Adverum aspires to transform the standard of care, preserve vision, and create a profound societal impact around the globe.

Adverum is looking for a Research Associate II or III (contract) to join our team in our Redwood City office. This position reports to a Scientist/Team Leader in Assay Development.  This person will be working with Assay Development, Quality Control, and Process Development departments.  This role is responsible for testing and troubleshooting molecular biology, ligand binding and protein characterization assays in support of product and process characterization.

Note to Recruiters and Agencies
All recruiter and agency inquiries must go through Adverum's internal Talent Acquisition team.  Unsolicited resumes sent to Adverum will be considered Adverum's property.   Adverum's Talent Acquisition team must expressly engage agencies for any requisition.  Direct contact with hiring managers by agencies will not be tolerated and may affect your ability to work with Adverum in the future.

 
What you'll do:

  • Work with senior scientific personnel to test and troubleshoot molecular biology, ligand binding and protein characterization assays in a subset of the following categories: 

  • Molecular biology assays including qPCR, ddPCR, and nucleic acid extraction

  • Ligand binding assays including ELISA

  • Protein characterization assays including chromatography, electrophoresis, and light scattering assays

  • Execute experimental plans.

  • Conduct sample analysis following standard procedures.

  • Participate in decisions on experimental approaches and interpretation of data.

  • Author test procedures, documented standard test methods, and SOPs.

  • Present project status updates to AD team members.

  • Maintain current knowledge of regulatory requirements for product characterization assays.

  • Maintain excellent documentation of laboratory activities.

  • Perform routine lab maintenance.

  • Other responsibilities may be assigned as needed.

About you:

  • Bachelor's degree in a life sciences field with 2+ years of relevant experience in a biotech company or fast-paced academic research lab, or an equivalent combination of education and experience.

  • Experience in generating high quality and reproducible data employing accurate documentation is required.

  • Knowledge of protein and DNA chemistry is required.

  • Experience with molecular biology, ligand binding, and/or protein characterization assays is strongly desired.

  • Experience in AAV-based gene therapy is a plus.

  • Knowledge of SoftMaxPro, QuantStudio, Empower, and/or other common analytical software is a plus.

  • Must be a self-starter, proactive, cooperative, and proficient at working both independently and in a small team environment.

  • Excellent verbal and written communication skills.

  • Proficient with MS Office and other common office software.

$25 - $40 an hour
Hourly depends on experience.
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