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Analytical Method Development Jobs in California

Abbott

Method Development Scientist

Santa Rosa, CA

$90K - $180K/yr

Career development with an international company where you can grow the career you dream of ... Troubleshoot existing analytical methods * Author, review, and verify validation protocols and ...

Abbott

Method Development Scientist

Santa Rosa, CA · On-site

$90K - $180K/yr

Career development with an international company where you can grow the career you dream of ... Troubleshoot existing analytical methods * Author, review, and verify validation protocols and ...

Abbott

Method Development Scientist

Santa Rosa, CA · On-site

$90K - $180K/yr

Career development with an international company where you can grow the career you dream of ... Troubleshoot existing analytical methods * Author, review, and verify validation protocols and ...

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All JobsAnalytical Method Development JobsAnalytical Method Development Jobs in California

Analytical Method Development information

See California salary details

$87.8K

$188.9K

$283.7K

How much do analytical method development jobs pay per year?

As of Jul 30, 2026, the average yearly pay for analytical method development in California is $188,905.00, according to ZipRecruiter salary data. Most workers in this role earn between $92,800.00 and $245,700.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the Analytical Method Development position, and why are they important?

To excel in Analytical Method Development, a strong background in chemistry, analytical techniques, and statistical analysis is typically required, often supported by a relevant science degree. Familiarity with laboratory instrumentation such as HPLC, GC, MS, and validation protocols, as well as experience with software like Empower or ChemStation, is highly valued. Attention to detail, problem-solving, and effective communication are crucial soft skills for this role. These competencies are vital to ensure robust method development, regulatory compliance, and effective teamwork in a laboratory setting.

What does a typical day look like for someone working in Analytical Method Development?

A typical day involves designing, executing, and optimizing analytical experiments to develop new testing methods or improve existing ones, often using advanced laboratory instruments. You may also analyze data, document results, troubleshoot instrument or methodological issues, and collaborate with scientists, quality assurance, and production teams. Regular tasks include preparing reports for regulatory submissions, participating in team meetings to discuss progress and challenges, and maintaining rigorous documentation standards. The role balances independent technical work with teamwork and cross-departmental communication to ensure methods meet performance, accuracy, and compliance standards.

What is an Analytical Method Development job?

An Analytical Method Development job involves designing, optimizing, and validating methods for analyzing pharmaceutical, chemical, or biological samples. Professionals in this role ensure accurate, reliable, and reproducible results by developing techniques like chromatography, spectroscopy, or titration. They collaborate with research, quality control, and regulatory teams to comply with industry standards and guidelines. This role is critical in drug development, manufacturing, and ensuring product quality and safety.

What are the most commonly searched types of Analytical Method Development jobs in California? The most popular types of Analytical Method Development jobs in California are:
Analytical Method Development jobs near you
Infographic showing various Analytical Method Development job openings in California as of July 2026, with employment types broken down into 89% Full Time, 8% Part Time, and 3% Contract. Highlights an 87% Physical, 4% Hybrid, and 9% Remote job distribution, with an average salary of $188,905 per year, or $90.8 per hour.

Principal Scientist - Analytical Methods Development

Programmable Medicine Operatin

Redwood City, CA • On-site

$165K - $200K/yr

Full-time

Medical, Dental, Vision

Posted 4 days ago

Job description

Programmable Medicine, a clinical stage biopharmaceutical company located in Redwood City, is seeking a motivated Chemist/Sr. Chemist Analytical Method Development. We are focused on developing novel nanomedicines, HD therapeutics (HDTs), to treat unmet medical needs in ophthalmology, neurology, inflammatory diseases, and neuro-oncology. Our HD platform builds therapeutics that are selectively taken up only by inflamed tissues, allowing us to treat diseases with unprecedented precision.
The successful candidate will provide scientific leadership for the development, qualification, stage-appropriate validation of analytical methods supporting complex large molecule therapeutics, including antibody drug conjugates, polymer-based platforms, and other nanomedicine products. The successful candidate will partner closely with Chemistry, Translational, Process Development, Formulation Development, Quality, Regulatory Affairs, Manufacturing, and external contract laboratories to establish robust analytical strategies that support product characterization, process understanding, product test and release, and regulatory submissions.
  • Subject matter expert in analytical methods development that uses scientific knowledge and experience to independently design, plan and execute studies in support of preclinical through Phase 2 programs
  • Performs analytical development and optimizes methods in support of preclinical studies through Phase 2
  • Creates and implements novel ideas and techniques to support analytical activities
  • Leads analytical technology transfersto GLP laboratories in support of GMP production
  • Writes analytical method development reports, SOPs, and analytical sections of regulatory submissions
  • Supervises laboratory personnel including setting priorities, monitoring work, execution of timelines, training to appropriate SOPs, meeting quality standards, and timely completion of documentation

Job Requirements
  • PhD in Analytical Chemistry or related discipline and 10+ years of relevant experience with at least 6 years of experience in the biotechnology/pharmaceutical or related industry
  • Demonstrated experience supporting complex large molecule therapeutics, including at least one of the following: antibody drug conjugates, dendrimers, polymers, biologics, bioconjugates, nanoparticles, or related products.
  • Extensive experience developing analytical methods supporting products from discovery through clinical development
  • Thorough understanding of analytical chemistry and a well-developed understanding of potential in-process impurities generated in production of antibody drug conjugates or polymer-drug conjugates
  • Strong working knowledge of analytical techniques, including: HPLC, SEC, LC-MS/MS, LC-MS, NMR spectroscopy, UV-Vis spectroscopy, , Dynamic Light Scattering (DLS), Zeta potential analysis, Multi-angle light scattering (MALS),.
  • Experience leading analytical method transfers to GMP manufacturing sites and familiarity with CDMO and CRO management
  • Strong knowledge of FDA, ICH, USP, EMA, and global CMC regulatory requirements and experience supporting regulatory submissions, including IND, NDA, and associated agency responses
  • Demonstrated understanding of cross-functional team membership related to drug development
  • Excellent project management skills with proven ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency
  • Previous experience supervising and optimizing the performance of a small scientific team
  • Extensive experience in developing analytical methods using fundamental scientific principles including peer reviewed publications as co-author or lead author

About Programmable Medicine
This is a unique opportunity to join a team focused on the development of a new class of precision medicines that selectively treat diseased cells in regions of inflammation. By making precision medicine even more precise, our nanomedicine technology has the potential to change the standard of care across ophthalmology, neurology, inflammatory diseases and neuro-oncology. You will have the opportunity to learn new skills and gain a better understanding of cutting-edge technology.
We have a comprehensive compensation package including fully paid medical, dental and vision benefits for you and your family. We want our employees to become shareholders and offer new hire stock options. The company also offers participation in the annual bonus program. The salary range for MS candidates located in the Bay Area, with a minimum of 8 years of industry experience is $165,000 - $200,000, depending on years of experience and relevant skill sets.

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