ZipRecruiter

Log In

1

Analytical Method Development Jobs in California

WuXi AppTec

Associate Analytical Scientist

San Diego, CA · On-site

$69K - $89K/yr

Perform / Assist in analytical method development, stress study, stability indication method development, IPC method development, residual solvent method development, etc. * Through the scientific ...

New

WuXi AppTec

Associate Analytical Scientist

San Diego, CA

$69K - $89K/yr

Perform / Assist in analytical method development, stress study, stability indication method development, IPC method development, residual solvent method development, etc. * Through the scientific ...

New

previous page

Showing results 41-60

All JobsAnalytical Method Development JobsAnalytical Method Development Jobs in California

Analytical Method Development information

See California salary details

$87.8K

$188.9K

$283.7K

How much do analytical method development jobs pay per year?

As of Aug 20, 2026, the average yearly pay for analytical method development in California is $188,905.00, according to ZipRecruiter salary data. Most workers in this role earn between $92,800.00 and $245,700.00 per year, depending on experience, location, and employer.

What is an analytical method development?

An Analytical Method Development job involves designing, optimizing, and validating methods for analyzing pharmaceutical, chemical, or biological samples. Professionals in this role ensure accurate, reliable, and reproducible results by developing techniques like chromatography, spectroscopy, or titration. They collaborate with research, quality control, and regulatory teams to comply with industry standards and guidelines. This role is critical in drug development, manufacturing, and ensuring product quality and safety.

What does an analytical method development do?

A typical day involves designing, executing, and optimizing analytical experiments to develop new testing methods or improve existing ones, often using advanced laboratory instruments. You may also analyze data, document results, troubleshoot instrument or methodological issues, and collaborate with scientists, quality assurance, and production teams. Regular tasks include preparing reports for regulatory submissions, participating in team meetings to discuss progress and challenges, and maintaining rigorous documentation standards. The role balances independent technical work with teamwork and cross-departmental communication to ensure methods meet performance, accuracy, and compliance standards.

What are the key skills and qualifications needed to thrive in analytical method development?

To excel in Analytical Method Development, a strong background in chemistry, analytical techniques, and statistical analysis is typically required, often supported by a relevant science degree. Familiarity with laboratory instrumentation such as HPLC, GC, MS, and validation protocols, as well as experience with software like Empower or ChemStation, is highly valued. Attention to detail, problem-solving, and effective communication are crucial soft skills for this role. These competencies are vital to ensure robust method development, regulatory compliance, and effective teamwork in a laboratory setting.

What are the most commonly searched types of Analytical Method Development jobs in California?

The most popular types of Analytical Method Development jobs in California are:

Analytical Method Development jobs near you
Infographic showing various Analytical Method Development job openings in California as of August 2026, with employment types broken down into 1% As Needed, 86% Full Time, 11% Part Time, and 2% Contract. Highlights an 89% Physical, 3% Hybrid, and 8% Remote job distribution, with an average salary of $188,905 per year, or $90.8 per hour.

Senior Scientist Analytical Development & Quality Control

Protagonist Therapeutics Inc.

Newark, CA • On-site

$140K - $160K/yr

Full-time

Re-posted 2 days ago

Job description

Senior Scientist Analytical Development & Quality Control
Protagonist Therapeutics is seeking a talented and highly motivated Senior Scientist to join the Analytical Development & Quality Control (ADQC) group. The successful candidate will help drive analytical development strategy for small-molecule and peptide candidates from early development through late-stage programs, including analytical method development, validation, transfer, stability programs, phase-appropriate specifications, and analytical control strategies for drug substance (DS) and drug product (DP). This role includes leading internal analytical activities, managing external CDMO partners, and collaborating closely with Drug Substance, Drug Product, Supply Chain, Quality Assurance, Regulatory, Nonclinical, and Clinical teams to achieve program objectives. This position reports to the Senior Director of ADQC.
Responsibilities
  • Develop, optimize, and validate analytical methods for release, stability, and characterization testing of DS and DP.
  • Lead impurity identification, degradant analysis, comparability assessments, method transfer, and analytical method lifecycle management.
  • Establish phase-appropriate, scientifically robust analytical control strategies, including characterization plans and specification setting, to support clinical and regulatory requirements and enable accelerated development timelines.
  • Troubleshoot analytical issues and support investigations, including OOS/OOT results, deviations, root-cause analysis, CAPA recommendations, and change-control activities, as applicable.
  • Manage stability and reference standard programs for assigned projects.
  • Communicate effectively with stakeholders and manage analytical development and QC testing activities at CDMOs.
  • Review CDMO data for release testing, stability testing, and DS/DP characterization to ensure scientific rigor, data integrity, and compliance.
  • Author analytical sections for regulatory filings, including INDs, IMPDs, and NDAs, and provide input to relevant Module 3 sections.
  • Participate in continuous improvement initiatives, including process and workflow improvements, CDMO management practices, and SOP development or revision in collaboration with Quality Assurance.
  • Represent ADQC in cross-functional team meetings.
Qualifications
  • PhD or MS in Analytical Chemistry or a relevant scientific discipline, with 5+ years of experience supporting early- and late-stage CMC development.
  • Hands-on expertise in UHPLC method development using a range of detection technologies, including UV, PDA, MALS, CAD, conductivity, fluorescence, and advanced MS for identification and structural characterization.
  • Extensive experience developing analytical methods for synthetic peptides or similarly complex drug substance molecules, such as ADCs, PEGylated proteins, or monoclonal antibodies, is highly preferred.
  • Demonstrated ability to solve complex scientific and business challenges.
  • Extensive experience communicating with and managing analytical development and QC functions at CDMOs.
  • Strong knowledge of cGMP/GLP compliance, pharmaceutical quality systems, and regulatory requirements for drug development.
  • Excellent written and verbal communication skills, with the ability to effectively represent analytical development plans to CDMOs, internal project teams, CMC teams, and senior management.
  • Ability to manage priorities and maintain timelines in a fast-paced environment while balancing speed, quality, and risk.
  • Strong project management, communication, leadership, and cross-functional collaboration skills.
  • Experience in small- to mid-size innovator companies is desired.
  • Ability to travel domestically and internationally, as needed.

The base pay range for this position at commencement of employment is expected to be between $140K and $160K / year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.
Protagonist Therapeutics is a discovery through late-stage development biopharmaceutical company. The Company's proprietary peptide technology platform enables de novo discovery of peptide therapeutics. Two novel peptides derived from Protagonist's proprietary discovery platform are at or near commercialization. ICOTYDE™ (icotrokinra) is approved in the U.S. for the treatment of moderate-to-severe plaque psoriasis in adults and pediatric patients 12 years of age and older who weigh at least 40 kg who are candidates for systemic therapy or phototherapy. ICOTYDE is the first and only targeted oral peptide that precisely blocks the Interleukin-23 receptor (IL-23R) licensed to Janssen Biotech, Inc.,a Johnson & Johnson company. ICOTYDE was jointly discovered by Protagonist and Johnson & Johnson scientists, with Protagonist having primary responsibility for the development of ICOTYDE through Phase 1, and Johnson & Johnson assuming responsibility for further development and commercialization. An NDA for rusfertide, a first-in-class hepcidin mimetic peptide that is being co-developed with Takeda Pharmaceuticals pursuant to a worldwide license and collaboration agreement entered in 2024, is under priority review with the FDA. Protagonist holds an option to co-commercialize rusfertide in the U.S. through a 50/50 profit and loss share structure or can opt-out of this structure. The Company also has a number of preclinical stage drug discovery programs addressing clinically and commercially validated targets including an oral IL-17 peptide antagonist, obesity dual and triple agonists, an oral hepcidin functional mimetic, and the recently announced IL-4 and amylin programs.
More information on Protagonist, its pipeline drug candidates, and clinical studies can be found on the Company's website at https://www.protagonist-inc.com.

Apply