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Analytical Method Development Jobs in California

Amgen

Analytical Scientist

Thousand Oaks, CA

Define analytical control strategies and implement methodologies for development of pivotal phase clinical programs. * Collaborate closely with drug substance and drug product process development ...

Actalent

Analytical Chemist Medical Device

Northridge, CA · On-site

$30 - $37/hr

This role includes assisting in method development, maintaining laboratory instrumentation, and ... Key Responsibilities Analytical Testing & Method Development * Perform routine and non-routine ...

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Analytical Method Development information

See California salary details

$87.8K

$188.9K

$283.7K

How much do analytical method development jobs pay per year?

As of May 31, 2026, the average yearly pay for analytical method development in California is $188,905.00, according to ZipRecruiter salary data. Most workers in this role earn between $92,800.00 and $245,700.00 per year, depending on experience, location, and employer.

What is an Analytical Method Development job?

An Analytical Method Development job involves designing, optimizing, and validating methods for analyzing pharmaceutical, chemical, or biological samples. Professionals in this role ensure accurate, reliable, and reproducible results by developing techniques like chromatography, spectroscopy, or titration. They collaborate with research, quality control, and regulatory teams to comply with industry standards and guidelines. This role is critical in drug development, manufacturing, and ensuring product quality and safety.

What are the key skills and qualifications needed to thrive in the Analytical Method Development position, and why are they important?

To excel in Analytical Method Development, a strong background in chemistry, analytical techniques, and statistical analysis is typically required, often supported by a relevant science degree. Familiarity with laboratory instrumentation such as HPLC, GC, MS, and validation protocols, as well as experience with software like Empower or ChemStation, is highly valued. Attention to detail, problem-solving, and effective communication are crucial soft skills for this role. These competencies are vital to ensure robust method development, regulatory compliance, and effective teamwork in a laboratory setting.

What does a typical day look like for someone working in Analytical Method Development?

A typical day involves designing, executing, and optimizing analytical experiments to develop new testing methods or improve existing ones, often using advanced laboratory instruments. You may also analyze data, document results, troubleshoot instrument or methodological issues, and collaborate with scientists, quality assurance, and production teams. Regular tasks include preparing reports for regulatory submissions, participating in team meetings to discuss progress and challenges, and maintaining rigorous documentation standards. The role balances independent technical work with teamwork and cross-departmental communication to ensure methods meet performance, accuracy, and compliance standards.
More about Analytical Method Development jobs
What are the most commonly searched types of Analytical Method Development jobs in California? The most popular types of Analytical Method Development jobs in California are:
Analytical Method Development jobs near you
Infographic showing various Analytical Method Development job openings in California as of May 2026, with employment types broken down into 97% Full Time, and 3% Part Time. Highlights an 70% Physical, 4% Hybrid, and 26% Remote job distribution, with an average salary of $188,905 per year, or $90.8 per hour.

Analytical & Product Quality Lead, Small Molecule

Retro

Redwood City, CA

Full-time

Medical, Dental, Vision, Retirement

Posted 8 days ago

Job description

Retro develops therapies for diseases driven by the biology of aging. We focus on cellular reprogramming and autophagy to rejuvenate cell and tissue function with the ultimate aim of adding 10 years to healthy human lifespan.

We are building a mission-driven, collaborative team operating with speed, transparency, and adaptability.

We are hiring a new member of the team who will lead analytical development and product quality strategy for RTR242, a small molecule in Phase I for the treatment of neurodegenerative diseases such as Alzheimer's. In this role, you will provide hands-on leadership for analytical development while owning the end-to-end product quality strategy across CMC, manufacturing, and QC. You will work with our CDMO and CRO partners to achieve quality standards appropriate to stage and intended use.

About You:
You are a rigorous and pragmatic quality leader with deep expertise in small molecule analytical development. You know how to build scientifically sound, risk-based control strategies that are fit-for-stage. You are comfortable owning the details-from specifications and stability strategy to analytical methods, critical quality attributes, and acceptance criteria. You work effectively across internal teams and external partners, identify gaps early, and drive practical solutions with a high bar for quality, compliance, and execution. You are motivated by the opportunity to help advance therapies for age-related neurodegenerative disease and contribute to extending healthy lifespan.
In This Role, You Will:

  • Lead Quality Assurance for RTR242, providing end-to-end oversight of manufacturing and QC activities at CDMOs, including tech transfer, performance monitoring, deviation oversight, issue resolution, and continuous improvement and data integrity.

  • Define and maintain a scientifically sound, risk-based, phase-appropriate control strategy across materials, manufacturing processes, analytical methods, and specifications to ensure product identity, strength, quality, purity, and stability in alignment with cGMP expectations.

  • As part of the control strategy, define, justify, and maintain drug substance and drug product specifications, including critical quality attributes, acceptance criteria, scientific rationale, and lifecycle management.

  • Collaborate with QMS Chapter leads and document owners to define, refine, and standardize quality requirements.

  • Lead the analytical method strategy across the product lifecycle, including QC release and stability methods supporting clinical development.

  • Oversee analytical method development, qualification, and validation at CDMOs and CROs in alignment with ICH guidance and phase-appropriate regulatory expectations.

  • Establish and oversee stability strategies, including protocol design, stability-indicating methods, data trending and interpretation, and shelf-life proposals.

  • Serve as the product quality subject-matter expert for investigations, deviations, and CAPAs, ensuring robust root cause analysis and effective resolution.

  • Identify and mitigate analytical, quality, and control strategy gaps and risks to support CMC readiness, compliant product release, and regulatory submissions.

  • Serve as the primary analytical and product quality interface with CDMOs and CROs, establishing clear responsibilities, robust quality agreements, and governance to support effective oversight and sustained inspection readiness.

  • Partner cross-functionally with Research, CMC, Regulatory Affairs, and QMS stakeholders to ensure analytical and quality strategies are scientifically sound, compliant, and clearly and defensibly documented.

  • Contribute to global regulatory submissions and support health authority interactions in collaboration with Regulatory Affairs. 

You Will Excel In This Role If You:

  • Bring 7+ years of experience in small-molecule analytical development, quality control, and/or product quality within a regulated pharmaceutical environment.

  • Have hands-on experience with analytical method development, validation, and transfer, including techniques such as HPLC, GC, dissolution, impurity methods, and related assays.

  • Have a strong working knowledge of ICH guidelines, GMP requirements, and regulatory expectations for clinical-stage small-molecule products.

  • Have experience supporting IND-enabling or early clinical CMC activities.

  • Have experience overseeing CDMO and/or CRO analytical activities, including method transfer, performance management, and external partner oversight.

  • Demonstrate strong judgment in identifying and addressing CMC, quality, and regulatory risks before they affect timelines or development progress.

  • Understand how analytical and quality expectations evolve across early clinical development and apply appropriate, phase-aligned rigor.

  • Communicate clearly and effectively across technical teams, senior leadership, and external stakeholders.

  • Have an advanced degree in Chemistry, Pharmaceutical Sciences, or a related scientific discipline, or equivalent experience.

It's A Bonus If You:

  • Have prior experience serving as a product quality or analytical lead within a matrixed organization.

  • Have prior experience leading or providing technical oversight for impurity identification, metabolite or degradation pathway characterization, and root cause investigations, leveraging LC/MS and related techniques.

  • Have experience supporting or leading formulation development activities.

  • Have exposure to regulatory interactions or authoring CMC sections related to analytical control strategies.

$195,000 - $215,000 a year

At Retro, we don't use titles. New hires join as a "Member of X Team."

Depending on experience, this role could flex from Senior Manager to Associate Director or Director level, depending on company stage and size.

Total compensation includes competitive base salary, generous equity, and benefits including:

  • Medical, dental, and vision insurance for you and your family

  • 401(k) plan with 4% matching

  • Flexible time off and 10 company holidays per year

  • Paid parental leave

  • Annual learning & development stipend

  • Monthly longevity stipend

  • Daily Retro-sponsored lunch and snacks

We take pride in cultivating an environment that fosters collaboration, open communication, and authenticity. We believe that great results are best delivered by a highly creative team working in concert. We are an equal opportunity employer; we do not discriminate based on race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. We are diverse in background and singular in mission.

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
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