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Analytical Method Development Jobs in California

Astrix Inc

Analytical Scientist

Thousand Oaks, CA · On-site

$57 - $62/hr

Essential Duties and Responsibilities • Drive special projects that require AQC attention/leadership. • Drive analytical method development and validation of laboratory methodologies and ...

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Analytical Method Development information

See California salary details

$87.8K

$188.9K

$283.7K

How much do analytical method development jobs pay per year?

As of Sep 10, 2026, the average yearly pay for analytical method development in California is $188,905.00, according to ZipRecruiter salary data. Most workers in this role earn between $92,800.00 and $245,700.00 per year, depending on experience, location, and employer.

What is an analytical method development?

An Analytical Method Development job involves designing, optimizing, and validating methods for analyzing pharmaceutical, chemical, or biological samples. Professionals in this role ensure accurate, reliable, and reproducible results by developing techniques like chromatography, spectroscopy, or titration. They collaborate with research, quality control, and regulatory teams to comply with industry standards and guidelines. This role is critical in drug development, manufacturing, and ensuring product quality and safety.

What does an analytical method development do?

A typical day involves designing, executing, and optimizing analytical experiments to develop new testing methods or improve existing ones, often using advanced laboratory instruments. You may also analyze data, document results, troubleshoot instrument or methodological issues, and collaborate with scientists, quality assurance, and production teams. Regular tasks include preparing reports for regulatory submissions, participating in team meetings to discuss progress and challenges, and maintaining rigorous documentation standards. The role balances independent technical work with teamwork and cross-departmental communication to ensure methods meet performance, accuracy, and compliance standards.

What are the key skills and qualifications needed to thrive in analytical method development?

To excel in Analytical Method Development, a strong background in chemistry, analytical techniques, and statistical analysis is typically required, often supported by a relevant science degree. Familiarity with laboratory instrumentation such as HPLC, GC, MS, and validation protocols, as well as experience with software like Empower or ChemStation, is highly valued. Attention to detail, problem-solving, and effective communication are crucial soft skills for this role. These competencies are vital to ensure robust method development, regulatory compliance, and effective teamwork in a laboratory setting.

Analytical Method Development jobs near you
Infographic showing various Analytical Method Development job openings in California as of August 2026, with employment types broken down into 1% As Needed, 77% Full Time, 18% Part Time, and 4% Contract. Highlights an 86% Physical, 3% Hybrid, and 11% Remote job distribution, with an average salary of $188,905 per year, or $90.8 per hour.

Research Associate - Gene Therapy Analytical Development 3663083

San Diego, CA • On-site

Axiom Path
Recruiting and Staffing Services • 51 - 200 employees
Learn more about Axiom Pathexternal

$50 - $53.57/hr

Full-time

Posted 10 days ago

Key responsibilities

  • Develop, execute, and optimize viral genome titer assays using ddPCR and qPCR technologies.

  • Design and evaluate primers and probes for assay specificity, sensitivity, and reproducibility.

  • Troubleshoot assay performance issues and conduct investigations into inconsistent or unexpected results.

Job description

Be Part Of A High-Performing Team

Join a science-driven biopharmaceutical organization focused on developing innovative therapies for patients with serious and rare diseases. This opportunity sits within a Gene Therapy Analytical Development group responsible for building reliable analytical methods that support advancing gene therapy programs through development. The environment is highly collaborative and hands-on, bringing together analytical development, quality, bioinformatics, and regulatory expertise to solve complex scientific challenges.

What's In Store For You

  • Engagement: W2 only (no C2C/1099)
  • Gain hands-on experience supporting analytical method development for gene therapy programs.
  • Work closely with experienced scientists while developing deeper expertise in molecular biology and viral vector analytics.
  • Collaborate with cross-functional partners across QC, Bioinformatics, and Regulatory CMC.
  • Contribute to assays that directly support the characterization and development of advanced therapeutics.

How You Will Make An Impact

  • Develop, execute, and optimize viral genome titer assays using ddPCR and qPCR technologies.
  • Design and evaluate primers and probes for specificity, sensitivity, precision, and reproducibility.
  • Optimize PCR assay conditions, including cycling parameters, template concentrations, and inhibitor-related variables.
  • Perform DNA and RNA extraction, purification, quantification, and sample preparation across multiple sample types.
  • Apply restriction enzyme digestion and other molecular biology techniques to support assay development.
  • Troubleshoot assay performance issues and conduct structured investigations into inconsistent or unexpected results.
  • Analyze experimental data and maintain accurate technical reports, laboratory notebooks, and supporting documentation.
  • Maintain laboratory records consistent with applicable GMP/GLP documentation practices.
  • Partner with analytical development, quality, bioinformatics, and regulatory colleagues to advance gene therapy programs.
  • Stay current with developments in ddPCR, molecular analytics, NGS, and gene therapy technologies.

Are You an Experienced Molecular Biology Research Associate Ready to Make an Impact?

  • B.S. or M.S. in Molecular Biology, Biochemistry, Biotechnology, or a closely related life sciences discipline.
  • Hands-on laboratory experience with qPCR and/or ddPCR, including assay setup, data interpretation, optimization, and troubleshooting.
  • Experience designing and evaluating PCR primers and probes.
  • Strong experience with DNA and RNA purification and quantification.
  • Familiarity with restriction enzyme digestion and standard molecular biology or cloning techniques.
  • Strong attention to detail with the ability to produce accurate, complete laboratory documentation.
  • Ability to work effectively in a fast-paced laboratory environment while receiving scientific direction from senior team members.
  • Strong written, verbal, analytical, and collaborative communication skills.
  • Direct experience with Bio-Rad QX200, QXOne, or another ddPCR platform is highly desirable.
  • Exposure to AAV or other viral vectors, analytical method development, GMP/GLP laboratories, NGS workflows, or JMP/statistical analysis is preferred.