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Analytical Method Development Jobs in California

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Analytical Method Development information

See California salary details

$87.8K

$188.9K

$283.7K

How much do analytical method development jobs pay per year?

As of Sep 10, 2026, the average yearly pay for analytical method development in California is $188,905.00, according to ZipRecruiter salary data. Most workers in this role earn between $92,800.00 and $245,700.00 per year, depending on experience, location, and employer.

What is an analytical method development?

An Analytical Method Development job involves designing, optimizing, and validating methods for analyzing pharmaceutical, chemical, or biological samples. Professionals in this role ensure accurate, reliable, and reproducible results by developing techniques like chromatography, spectroscopy, or titration. They collaborate with research, quality control, and regulatory teams to comply with industry standards and guidelines. This role is critical in drug development, manufacturing, and ensuring product quality and safety.

What does an analytical method development do?

A typical day involves designing, executing, and optimizing analytical experiments to develop new testing methods or improve existing ones, often using advanced laboratory instruments. You may also analyze data, document results, troubleshoot instrument or methodological issues, and collaborate with scientists, quality assurance, and production teams. Regular tasks include preparing reports for regulatory submissions, participating in team meetings to discuss progress and challenges, and maintaining rigorous documentation standards. The role balances independent technical work with teamwork and cross-departmental communication to ensure methods meet performance, accuracy, and compliance standards.

What are the key skills and qualifications needed to thrive in analytical method development?

To excel in Analytical Method Development, a strong background in chemistry, analytical techniques, and statistical analysis is typically required, often supported by a relevant science degree. Familiarity with laboratory instrumentation such as HPLC, GC, MS, and validation protocols, as well as experience with software like Empower or ChemStation, is highly valued. Attention to detail, problem-solving, and effective communication are crucial soft skills for this role. These competencies are vital to ensure robust method development, regulatory compliance, and effective teamwork in a laboratory setting.

Analytical Method Development jobs near you
Infographic showing various Analytical Method Development job openings in California as of August 2026, with employment types broken down into 1% As Needed, 77% Full Time, 18% Part Time, and 4% Contract. Highlights an 86% Physical, 3% Hybrid, and 11% Remote job distribution, with an average salary of $188,905 per year, or $90.8 per hour.

Principal Scientist, Analytical Development

South San Francisco, CA • On-site

Scorpion Therapeutics
51 - 200 employees
Learn more about Scorpion Therapeuticsexternal

Other

Posted 11 days ago

Job description

About the Role

  • Onsite (South San Francisco, CA). Principal Scientist, Potency; reports to Sr. Director, Head of Molecular and Potency Method Development.


Responsibilities

  • Develop and qualify pivotal stage potency, immunoassay, and other cell-based methods to support characterization, process development, release, and stability testing.

  • Follow ICH and internal Method Development guidance to develop robust analytical methods (including measuring residual impurities) for intermediates and drug substances/products.

  • Create product characterization strategies and methodologies for the pipeline.

  • Develop and execute methods to implement control strategies for gene and cell therapy products.

  • Document experimental procedures/results in ELN; complete required notebook review/approval.

  • Present results and communicate with cross-functional technical, analytical, and biological stakeholders.

  • Serve as a subject matter expert for potency/immunoassay/cell-based methods.

  • Draft/review/approve technical documents (Test Methods, SOPs, Development/Technical Reports, study plans).

  • Calibrate, maintain, troubleshoot, and qualify instruments/reagents; maintain reagent inventory and improve lab efficiency.

  • Support Quality Control on method transfer, qualification, and testing at CDMOs and internally.

  • Resolve development obstacles via creative solutions, collaboration, and problem-solving.


Qualifications & Skills

  • PhD with 8+ years or MS with 10+ years industry experience.

  • Deep expertise in pluripotent stem cell or stem cell-derived drug products.

  • Experience developing/qualifying late-stage potency methods for pluripotent stem cell or stem cell-derived pancreatic islet cell products (FDA/ICH/USP).

  • Proficient independent data analysis using JMP or other statistical software; draw conclusions and recommend next steps.

  • Experience with pCQA assessment and specification setting.

  • Strong Microsoft Office; experience with data analysis tools (e.g., JMP, SoftMax Pro) and Smartsheet.

  • Mammalian cell culture and aseptic generation of cell stocks.


Preferred/Additional

  • Statistical software (JMP) for DOE, visualization, and analysis.

  • Analytical method development for pivotal/commercial cell therapeutics; familiarity with FDA/ICH and GxP.

  • Experience partnering with Quality Control for GMP testing and method transfer.

  • Self-motivated, accountable, critical thinking, troubleshooting/problem-solving; multitasking and effective communication.

  • Managing direct reports.

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