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Analytical Method Development Jobs in California

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Analytical Method Development information

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$87.8K

$188.9K

$283.7K

How much do analytical method development jobs pay per year?

As of May 31, 2026, the average yearly pay for analytical method development in California is $188,905.00, according to ZipRecruiter salary data. Most workers in this role earn between $92,800.00 and $245,700.00 per year, depending on experience, location, and employer.

What is an Analytical Method Development job?

An Analytical Method Development job involves designing, optimizing, and validating methods for analyzing pharmaceutical, chemical, or biological samples. Professionals in this role ensure accurate, reliable, and reproducible results by developing techniques like chromatography, spectroscopy, or titration. They collaborate with research, quality control, and regulatory teams to comply with industry standards and guidelines. This role is critical in drug development, manufacturing, and ensuring product quality and safety.

What are the key skills and qualifications needed to thrive in the Analytical Method Development position, and why are they important?

To excel in Analytical Method Development, a strong background in chemistry, analytical techniques, and statistical analysis is typically required, often supported by a relevant science degree. Familiarity with laboratory instrumentation such as HPLC, GC, MS, and validation protocols, as well as experience with software like Empower or ChemStation, is highly valued. Attention to detail, problem-solving, and effective communication are crucial soft skills for this role. These competencies are vital to ensure robust method development, regulatory compliance, and effective teamwork in a laboratory setting.

What does a typical day look like for someone working in Analytical Method Development?

A typical day involves designing, executing, and optimizing analytical experiments to develop new testing methods or improve existing ones, often using advanced laboratory instruments. You may also analyze data, document results, troubleshoot instrument or methodological issues, and collaborate with scientists, quality assurance, and production teams. Regular tasks include preparing reports for regulatory submissions, participating in team meetings to discuss progress and challenges, and maintaining rigorous documentation standards. The role balances independent technical work with teamwork and cross-departmental communication to ensure methods meet performance, accuracy, and compliance standards.
More about Analytical Method Development jobs
What are the most commonly searched types of Analytical Method Development jobs in California? The most popular types of Analytical Method Development jobs in California are:
Analytical Method Development jobs near you
Infographic showing various Analytical Method Development job openings in California as of May 2026, with employment types broken down into 97% Full Time, and 3% Part Time. Highlights an 70% Physical, 4% Hybrid, and 26% Remote job distribution, with an average salary of $188,905 per year, or $90.8 per hour.
Associate Scientist, Analytical Development

Associate Scientist, Analytical Development

Denali Therapeutics

South San Francisco, CA • On-site

$106K - $138K/yr

Full-time

Medical, Retirement

Posted 4 days ago

Job description

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.
We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.
This position is part of a broader Large Molecule CMC Analytical and Formulation team. This is an opportunity to collaborate on formulation, process and analytical development activities across a broad range of large molecules, that cross the blood-brain barrier, for treating challenging diseases.
Key Accountabilities/Core Job Responsibilities:
  • Assist in the development of chromatography, electrophoresis, spectroscopy and mass spectrometry-based analytical methods to be used for product release, stability, and characterization testing.
  • Contribute to the design and execution of experiments for demonstrating method robustness and performance.
  • Prioritize and perform timely testing that enables bioprocess and formulation development teams to meet project timelines.
  • Critically evaluate analytical data to support method development decisions and product quality comparisons.
  • Maintain accurate and timely experiment records in electronic laboratory notebook (ELN).
  • Summarize and present data in a clear and meaningful way.
  • Author and review analytical test methods and development reports.

Qualifications/Skills:
  • B.S. or M.S. in Analytical Chemistry, Biochemistry, Chemical Engineering, Pharmaceutical Sciences or related scientific discipline with 2+ years of CMC analytical development experience in biotech/pharma.
  • Hands-on experience with various analytical methods for measuring the purity of biologics and residual process impurities (i.e. chromatography, capillary electrophoresis, spectroscopy, LC-MS, etc.).
  • Experience with chromatography and mass spectrometry acquisition and data analysis software.
  • Excellent laboratory, critical thinking, scientific problem-solving, and organizational skills.
  • Familiarity with good documentation requirements and industry guidance.
  • Knowledge of statistical approaches for data interpretation and analytical method development.
  • Motivated, detail-oriented, naturally curious individual with a creative approach to scientific problem solving.
  • Excellent spoken and written communication skills.

Salary Range: $106,000.00 to $138,000.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers
This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.
Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

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