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Ai Software Developer Jobs in Minnesota (NOW HIRING)

Senior AI-ML Engineer

Rochester, MN · On-site +1

$106K - $145K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

Responsibilities AI/ML Engineers at Mayo Clinic play a pivotal role in the union of data, systems ... You will develop, integrate, and standardize software components and create, maintain, and follow ...

Senior Legal AI Engineer

Eagan, MN · On-site

$124K - $164K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Software engineering experience, including experience focused on AI/ML or LLM-powered applications. * Proficiencyin Python * Strong understanding of machine learning concepts, LLM evaluation ...

AI-ML Engineer - Finance-Hybrid

Rochester, MN · Hybrid

  • Medical

  • Dental

  • Vision

  • Retirement

AI/ML Engineers at Mayo Clinic play a pivotal role in the union of data, systems, and computer ... You will develop, integrate, and standardize software components and create, maintain, and follow ...

AI-Native Software Engineer

Mendota Heights, MN · On-site

$112K - $176K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

AI-Native Software Engineer AI-Native Software Engineer PLEASE NOTE: This position is not eligible for current or future visa sponsorship Location : This role requires associates to be in-office 3 ...

Senior AI/ML Engineer

Rochester, MN · On-site

$95K - $131K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

Responsibilities AI/ML Engineers at Mayo Clinic play a pivotal role in the union of data, systems ... You will develop, integrate, and standardize software components and create, maintain, and follow ...

AI Developer

Saint Paul, MN · On-site

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Bachelor's degree in Computer Science or a related field * 15 years of experience in software engineering and applied AI * Possess proven experience designing scalable distributed AI systems, and are ...

AI-ML Engineer - Finance-Hybrid

Rochester, MN · Hybrid

  • Medical

  • Dental

  • Vision

  • Retirement

AI/ML Engineers at Mayo Clinic play a pivotal role in the union of data, systems, and computer ... You will develop, integrate, and standardize software components and create, maintain, and follow ...

AI-ML Engineer - Finance-Hybrid

Rochester, MN · Hybrid

  • Medical

  • Dental

  • Vision

  • Retirement

AI/ML Engineers at Mayo Clinic play a pivotal role in the union of data, systems, and computer ... You will develop, integrate, and standardize software components and create, maintain, and follow ...

Senior Software Engineer

Maplewood, MN · On-site

$125K - $165K/yr

The Impact You'll Make in this Role As a Senior Software Engineer, you will have the opportunity to ... Proficiency with AI software development tools Work location: * Work location: This role follows an ...

New

Senior Software Engineer

Maplewood, MN · On-site

$125K - $165K/yr

The Impact You'll Make in this Role As a Senior Software Engineer, you will have the opportunity to ... Proficiency with AI software development tools Work location: * Work location: This role follows an ...

Senior Software Engineer

Maplewood, MN · On-site

$125K - $165K/yr

The Impact You'll Make in this Role As a Senior Software Engineer, you will have the opportunity to ... Proficiency with AI software development tools Work location: * Work location: This role follows an ...

Lead Software Engineer AI (Staff Engineer)

Eagan, MN · On-site

$127.40 - $236.60/hr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

## Lead Software Engineer AI (Staff Engineer)Applyremote type: Hybridlocations: United States of America, Eagan, Minnesota: United States of America, Frisco, Texas: Canada, Toronto, Ontario: United ...

Senior Software Engineer - AI (Materia AI)

Eagan, MN · On-site

$124K - $164K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Senior Software Engineer - AI (Materia AI) We're building the next generation of AI-powered ... Strengthen CI/CD pipelines and DevOps automation to support fast, stable, cloud-native development ...

Senior AI/ML Engineer

Rochester, MN · On-site

$95K - $131K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

AI/ML Engineers at Mayo Clinic play a pivotal role in the union of data, systems, and computer ... You will develop, integrate, and standardize software components and create, maintain, and follow ...

Showing results 41-60

Ai Software Developer information

See Minnesota salary details

$47K

$109.5K

$162.6K

How much do ai software developer jobs pay per year?

As of Aug 17, 2026, the average yearly pay for ai software developer in Minnesota is $109,542.00, according to ZipRecruiter salary data. Most workers in this role earn between $88,100.00 and $127,300.00 per year, depending on experience, location, and employer.

What is an AI software developer?

An AI Software Developer designs, develops, and implements artificial intelligence solutions, such as machine learning models, neural networks, and automation tools. They work with algorithms, big data, and programming languages like Python to build intelligent applications. Their responsibilities include data preprocessing, model training, testing, and deploying AI systems for various industries.

What are the key skills and qualifications needed to thrive as an AI software developer?

To thrive as an AI Software Developer, you need strong programming skills in languages such as Python or Java, a background in computer science or a related field, and a solid understanding of machine learning algorithms. Familiarity with frameworks like TensorFlow, PyTorch, and experience with data processing tools or cloud platforms is highly valued, while certifications in AI or machine learning can be advantageous. Creative problem-solving, collaboration, and effective communication are key soft skills that help you integrate complex solutions and work effectively within multidisciplinary teams. These competencies are crucial for developing, deploying, and maintaining innovative AI systems that deliver real-world value.

What are some common challenges faced by AI software developers in day-to-day work?

AI Software Developers often encounter challenges such as ensuring data quality and quantity, tuning complex models for optimal performance, and integrating AI components seamlessly into existing software systems. Balancing the need for accuracy with computational efficiency while addressing issues of scalability and maintainability can also be demanding. Additionally, they must continuously stay updated with rapidly evolving AI technologies and best practices. Overcoming these challenges requires adaptability, a passion for continuous learning, and close collaboration with data scientists, product managers, and other engineers.

How much do AI software developers make?

AI software developers typically earn between $80,000 and $150,000 annually, depending on experience, location, and industry. Senior roles or those with specialized skills in machine learning and deep learning can earn higher salaries, often exceeding $200,000. Compensation also varies based on certifications, education, and the complexity of projects handled.

Will AI take AI software developer jobs?

AI software developers create and maintain AI systems, and their roles are less likely to be fully replaced by AI itself. Instead, AI tools can augment their work by automating routine tasks, allowing developers to focus on complex problem-solving and innovation. Continuous learning of programming languages, machine learning frameworks, and staying updated on AI advancements are important for job security in this field.

What are popular job titles related to Ai Software Developer jobs in Minnesota?

For Ai Software Developer jobs in Minnesota, the most frequently searched job titles are:

What cities in Minnesota are hiring for Ai Software Developer jobs?

Cities in Minnesota with the most Ai Software Developer job openings:

Infographic showing various Ai Software Developer job openings in Minnesota as of August 2026, with employment types broken down into 1% As Needed, 84% Full Time, 10% Part Time, 4% Contract, and 1% Nights. Highlights an 87% Physical, 4% Hybrid, and 9% Remote job distribution, with an average salary of $109,542 per year, or $52.7 per hour.

Senior AI-ML Engineer

Mayo Clinic

Rochester, MN • On-site, Remote

$106K - $145K/yr

Full-time

Medical, Dental, Vision, Retirement

Posted 7 days ago


Mayo Clinic rating

7.8

Company rating: 7.8 out of 10

Based on 699 frontline employees who took The Breakroom Quiz

128th of 887 rated healthcare providers


Job description

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans - to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights
  • Medical: Multiple plan options.
  • Dental: Delta Dental or reimbursement account for flexible coverage.
  • Vision: Affordable plan with national network.
  • Pre-Tax Savings: HSA and FSAs for eligible expenses.
  • Retirement: Competitive retirement package to secure your future.

Responsibilities

AI/ML Engineers at Mayo Clinic play a pivotal role in the union of data, systems, and computer sciences. They work closely with a multidisciplinary team, including clinicians, user experience designers, product managers, IT professionals, and external partners, to develop and deploy effective, efficient, and ethical AI/ML solutions into clinical practice to enhance patient care and operational efficiency.
 

As a Senior AI/ML Engineer, you may work on the full spectrum of the AI life cycle from ideation to production. You understand the clinical environment well, including workflows, challenges, and requirements of healthcare providers and patients. You will leverage advanced techniques in AI/ML to analyze vast amounts of healthcare data, including patient records, medical imaging, and genomic information, to develop AI solutions that meet clinical needs and are integrated smoothly into clinical processes. You will develop, integrate, and standardize software components and create, maintain, and follow quality system procedures. You will guide the engineering of systems that are pivotal to developing and deploying these solutions, which encompass everything from design requirements, development, component creation, verification, non-clinical validation, and risk mitigation to ensure our digital health technology products meet and exceed regulatory requirements and setting new benchmarks for safety and effectiveness in clinical settings. Your expertise will also extend to facilitating consistent and automated AI software solution development and releases through the design, testing, and maintenance of tools and associated CI/CD pipelines. 
This role is instrumental in providing consultative services to departments and divisions, offering insights into complex business problems. Your ability to communicate complex findings in easily understandable terms to non-technical users will bridge the gap between sophisticated AI technologies and clinical applications.

   Leading component design, development, integration, and standardization to create AI-driven solutions that seamlessly integrate into clinical practice to enhance patient care and clinic operations.
   Collaborating with a multidisciplinary team, including clinicians, user experience designers, product managers, and IT professionals, to understand user needs, workflows, and clinical requirements and assess feasibility. Translating user feedback and requirements into design concepts and usability specifications for AI solutions.
   Leveraging machine learning techniques such as deep learning, natural language processing, computer vision, large language models, etc., to lead the design, development, and deployment of end-to-end AI solutions for healthcare applications.
   Establishing evaluation methodologies and performance metrics to assess AI solutions' effectiveness, usability, and impact in real-world healthcare settings.
   Explaining data analysis results to guide strategic choices and clarify complex insights for non-technical users to connect AI technologies and clinical applications. 
   Overseeing the engineering of systems crucial for developing and deploying AI solutions.
   Facilitating consistent and automated AI software solution development and releases through the design, testing, and maintenance of tools and associated CI/CD pipelines.
   Contributing to implementing the best practices and standards for AI development and deployment methodologies, tools, and platforms.
   Providing mentorship, guidance, and technical leadership to junior engineers within the AI enablement team. 
   Providing consultative services on areas of expertise to clinical work units or AI product teams, offering insights and strategies to address complex business problems.
   Providing training and education to healthcare staff on AI tools and technologies.
   Contributing to developing new AI methods and technologies that can advance the state-of-the-art in healthcare AI. 

This position is a combination of remote and on-site work; individual must live within a 100 mile driving distance to the Arizona, Jacksonville or Rochester Mayo Clinic campus.

**Visa sponsorship is not available for this position.  Also, Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program.


Qualifications

  A master's degree in engineering, computer science, mathematics, health science, or a related field with 4 years of experience, a bachelor's degree with 6 years of experience. 
  Extensive experience applying AI and machine learning in production healthcare environments or similar highly regulated or technology focused industries, showcasing an understanding of healthcare technology.
  Demonstrated leadership in managing complex projects, with a proven ability to navigate intricate project requirements and deliver successful outcomes.
  Proficiency in fostering collaboration across diverse teams and effectively communicating complex technical concepts to non-technical stakeholders.
  Demonstrated expertise in cloud infrastructure environment and software development tools.
  Experience working with large, complex, and heterogeneous data sets, preferably in healthcare. 
  Skilled in AI/ML techniques and frameworks.
  Familiarity with best practices in data engineering, data science, AI Engineering, and the MLOps communities.
  Demonstrated initiative in administration, education, software development, and technical reporting. 
  A commitment to mentoring and training less-experienced team members, coupled with strong interpersonal, communication, and time management skills.


Preferred Qualifications: 
  A Ph.D. or other doctorate is preferred. 
  Strong expertise in AI/ML techniques and frameworks, such as deep learning, natural language processing, and Generative AI, with proficiency in tools like Python, TensorFlow, PyTorch, sci-kit-learn, Keras, etc.
  Knowledge of the healthcare domain, including clinical workflows, electronic health records, medical terminologies, regulatory requirements, and industry standards.
  Familiarity with systems or quality engineering best practices, regulatory standards, and compliance frameworks, with the ability to adapt these effectively to different project scenarios.
  Demonstrated experience leading technical/quantitative teams in a regulated environment.
  Demonstrated experience creating risk management files and verification/validation strategies for digital health technology products within the healthcare industry.
  Strong expertise in user-centered design, human factors engineering, usability testing methodologies, and evaluation across AI product development. Ability to conduct expert reviews using established usability practices and methods. Presents findings in easy-to-understand terms for the business or clinical practice.


Exemption Status
Exempt
Compensation Detail
$137,134.40 - $205,691.20 / year
Benefits Eligible
Yes
Schedule
Full Time
Hours/Pay Period
80
Schedule Details
Monday - Friday, 8:00 a.m. - 5:00 p.m. (local time)
International Assignment
No
Site Description
Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is. 

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the 'EOE is the Law'.  Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Recruiter
Pam SivlyQualifications:

  A master's degree in engineering, computer science, mathematics, health science, or a related field with 4 years of experience, a bachelor's degree with 6 years of experience. 
  Extensive experience applying AI and machine learning in production healthcare environments or similar highly regulated or technology focused industries, showcasing an understanding of healthcare technology.
  Demonstrated leadership in managing complex projects, with a proven ability to navigate intricate project requirements and deliver successful outcomes.
  Proficiency in fostering collaboration across diverse teams and effectively communicating complex technical concepts to non-technical stakeholders.
  Demonstrated expertise in cloud infrastructure environment and software development tools.
  Experience working with large, complex, and heterogeneous data sets, preferably in healthcare. 
  Skilled in AI/ML techniques and frameworks.
  Familiarity with best practices in data engineering, data science, AI Engineering, and the MLOps communities.
  Demonstrated initiative in administration, education, software development, and technical reporting. 
  A commitment to mentoring and training less-experienced team members, coupled with strong interpersonal, communication, and time management skills.


Preferred Qualifications: 
  A Ph.D. or other doctorate is preferred. 
  Strong expertise in AI/ML techniques and frameworks, such as deep learning, natural language processing, and Generative AI, with proficiency in tools like Python, TensorFlow, PyTorch, sci-kit-learn, Keras, etc.
  Knowledge of the healthcare domain, including clinical workflows, electronic health records, medical terminologies, regulatory requirements, and industry standards.
  Familiarity with systems or quality engineering best practices, regulatory standards, and compliance frameworks, with the ability to adapt these effectively to different project scenarios.
  Demonstrated experience leading technical/quantitative teams in a regulated environment.
  Demonstrated experience creating risk management files and verification/validation strategies for digital health technology products within the healthcare industry.
  Strong expertise in user-centered design, human factors engineering, usability testing methodologies, and evaluation across AI product development. Ability to conduct expert reviews using established usability practices and methods. Presents findings in easy-to-understand terms for the business or clinical practice.


What Mayo Clinic employees say

Pay

Benefits

Hours and flexibility

Workplace

Get the full story on Breakroom


Mayo Clinic logo

About Mayo Clinic

Sourced by ZipRecruiter

Mayo Clinic is the largest integrated, not-for-profit medical group practice in the world. We're building the future, one where the best possible care is available to everyone — and more people can heal at home. Our relentless research turns into earlier diagnoses and new cures. That's how we inspire hope in those who need it most. At Mayo Clinic, experts work together to solve the most challenging unmet needs of patients. Our history of innovation dates back almost 150 years, when brothers Will and Charlie Mayo pioneered an integrated, team-based approach to medicine. Today, that trailblazing spirit drives innovations like Mayo Clinic Platform — which powers new technologies to change how care is delivered to all.

Industry

Hospitals

Company size

10,000+ Employees

Headquarters location

Rochester, MN, US

Year founded

1919