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Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once‑daily, oral, liver‑directed THR‑β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high‑performing culture that values scientific excellence, operational rigor, and collaboration.

This role is primarily responsible for nonclinical ADME strategy and oversight, while supporting Clinical Pharmacology and early clinical development as a subject matter expert. The Senior Director, ADME will provide technical leadership and execution for ADME activities supporting nonclinical and clinical development programs. This individual will bring deep expertise in drug metabolism, with working knowledge across broader ADME disciplines, and will oversee all ADME studies conducted through CRO partners. The role requires strong hands‑on scientific judgment to design, interpret, and integrate ADME data to support program decisions and regulatory submissions.

• Serve as the ADME subject matter expert, with deep expertise in metabolism.
• Define and execute ADME strategies in collaboration with functional area leads.
• Design, oversee, and interpret nonclinical ADME studies (in vitro and in vivo).
• Manage CROs, including vendor selection, study design, protocol development, and report review.
• Ensure ADME data are scientifically sound and aligned with regulatory expectations.
• Support clinical development through ADME input, including DDI risk assessment, PBPK modeling, and human ADME (mass balance) study design and interpretation.
• Integrate nonclinical and emerging clinical PK data to inform ADME strategy and study design.
• Author and review ADME sections of regulatory submissions (IND/CTA, NDA) and support regulatory interactions.

• Ph.D. in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or related discipline (or equivalent experience).
• 15+ years of ADME experience in pharmaceutical or biotechnology drug development.
• Experience supporting both nonclinical and clinical programs.
• Deep expertise in drug metabolism (required).
• Working knowledge of transporters and broader ADME sciences.
• Strong experience designing and interpreting ADME studies.
• Experience with PBPK modeling and human ADME (mass balance) studies preferred.

• Strong scientific judgment and attention to detail.
• Hands‑on, execution‑focused approach.
• Effective communicator within technical and cross‑functional teams.
• Ability to operate in a fast‑paced, dynamic environment.

Base salary range: $256,000 – $313,000 per year (as of the date of this posting). Madrigal offers equity to all full‑time employees and a comprehensive benefits package including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) with employer match. Additional voluntary benefits include supplemental life insurance, legal services, and mental health support through an Employee Assistance Program. The company also provides other benefits in accordance with applicable federal, state, and local laws.

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.