46 Illumina Program Manager Jobs Hiring Near You

The Head of R&D Portfolio & Project Management Office (PMO) reports to the Senior Director of R&D Strategy & Portfolio. The leader will own the design, deployment, and continuous improvement of scalable PMO practices, translating portfolio priorities into execution plans, overseeing governance, and building talent to support increasingly complex, cross‑functional R&D initiatives.

• Lead the R&D PMO to ensure execution rigor, predictable delivery, and operational discipline across a complex R&D portfolio.
• Ensure initiatives are delivered on time, on budget, and to defined quality standards, with strong risk and dependency management.
• Own and continuously improve PMO standards, methodologies, governance and tools, including fit‑for‑purpose product development and delivery frameworks.
• Integrate AI into PMO processes to increase overall project delivery efficiency.
• Enable effective portfolio governance in partnership with R&D Strategy and Portfolio Operations & Insights, Corporate Strategy, Product Management, and business group leaders.
• Operationalize portfolio priorities into executable programs, roadmaps, and capacity‑informed plans.
• Provide execution‑based insights to inform portfolio trade‑offs, sequencing, and governance decisions.
• Deliver clear, consistent execution reporting, dashboards, and metrics to R&D leadership and cross‑functional leadership.
• Serve as trusted execution partner to senior executives and cross‑functional leaders in a complex matrixed environment.
• Drive cross‑R&D alignment and collaboration to manage interdependencies and accelerate delivery.
• Champion transparency and accountability through effective reporting and insights.

• Attract, develop, and retain top‑tier PMO and R&D talent.
• Coach and mentor PM talent to strengthen core competencies and career progression.
• Foster a high‑performing, inclusive culture focused on innovation, adaptability, and measurable outcomes.

• Execution excellence: deep expertise in driving delivery rigor across complex, cross‑functional portfolios.
• PMO leadership: proven ability to design, scale, and sustain PMO operating models, standards, and tools.
• Data‑driven decision making: leverage analytics and insights to inform execution and portfolio decisions.
• Change leadership: effectively lead adoption of new ways of working with minimal disruption.
• Global mindset: operates effectively across geographies, cultures, and matrixed organizations.

• Advanced degree in Life Sciences, Business, or related field; MBA or PhD preferred.
• 12‑15+ years of experience in R&D portfolio / project management and operations leadership.
• Demonstrated success building PMO capabilities, strengthening delivery performance, and developing PMO talent.
• Experience running development programs that include different product types: instruments, assays, regulated products, and software.
• Advanced understanding of stage‑gate product development process and risk management.
• Strong communication, leadership, and stakeholder management skills effective in matrixed organizations.
• Ability to work independently and collaboratively across all levels of the organization.
• Positive change agent – experience leading effective change management practices.
• PMP or similar certification preferred.
• #LI-HYBRID

The estimated base salary range for the Head of R&D Portfolio & Project Management role based in the United States of America is: $205,100 – $307,700. Employees are eligible for bonus or commission and equity as part of the compensation package. Benefits include access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off.

Illumina is an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made.

This role is not eligible for visa sponsorship.