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Upstream Process Development Jobs in Boston, MA (NOW HIRING)

ElevateBio

Biomanufacturing Associate II

Waltham, MA

$38 - $52/hr

... upstream processing, downstream processing, aseptic fill finish and final product visual inspection ... Work effectively with cross functional teams comprised of process development, facilities ...

Zealand Pharma

Global Head of Drug Substance

Cambridge, MA · On-site

$251K - $307K/yr

Broad experience across the full process development cycle, including synthetic route scouting, salt selection, upstream and downstream process optimization, and evaluation of process alternatives ...

Zealandpharma

Global Head of Drug Substance

Cambridge, MA · On-site

$251K - $307K/yr

Broad experience across the full process development cycle, including synthetic route scouting, salt selection, upstream and downstream process optimization, and evaluation of process alternatives ...

ElevateBio

Biomanufacturing Associate II

Waltham, MA · On-site

$38 - $52/hr

... upstream processing, downstream processing, aseptic fill finish and final product visual inspection ... Work effectively with cross functional teams comprised of process development, facilities ...

Valspec

Process Validation Engineer

Boston, MA

$70 - $80/hr

Process Engineer -- Upstream / Downstream / Clean Utilities (Consultant) -- Contract Engagement ... Join a team where your contributions matter, your development is prioritized, and your success is ...

New

Lancesoft

Senior Engineer

Lexington, MA · On-site

$58 - $62.14/hr

This individual will also provide expertise and leadership in tech transfer to the upstream ... Process Monitoring A key part of this role will be assisting with continued development of the ...

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All JobsUpstream Process Development JobsUpstream Process Development Jobs in Boston, MA

Upstream Process Development information

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How much do upstream process development jobs pay per hour?

As of Jul 22, 2026, the average hourly pay for upstream process development in Boston, MA is $28.81, according to ZipRecruiter salary data. Most workers in this role earn between $25.58 and $30.29 per hour, depending on experience, location, and employer.

What jobs pay 500,000 a year in the US?

In the field of Upstream Process Development, senior roles such as Director or Vice President can reach or exceed $500,000 annually, especially with bonuses and stock options. These positions typically require extensive experience, advanced degrees, and leadership skills in biopharmaceutical or biotech industries. High compensation is often associated with managerial responsibilities, strategic decision-making, and overseeing large teams or projects.

What are the key skills and qualifications needed to thrive in Upstream Process Development, and why are they important?

Success in Upstream Process Development requires a strong background in biology, biochemistry, or chemical engineering, often with an advanced degree and experience in cell culture or fermentation techniques. Familiarity with bioreactors, process control systems, and analytical instrumentation, as well as knowledge of cGMP regulations, is essential. Critical thinking, problem-solving, and effective communication are important soft skills for optimizing processes and collaborating across multidisciplinary teams. These competencies ensure efficient development of scalable production processes, maintaining product quality and regulatory compliance.

What are common upstream jobs?

Common upstream process development jobs include roles such as upstream process scientist, bioprocess engineer, and fermentation scientist. These positions focus on developing and optimizing the early stages of biopharmaceutical production, often requiring knowledge of cell culture, bioreactor operation, and process scale-up. Skills in laboratory techniques, process analytical technology, and regulatory compliance are also important in these roles.

What biology jobs pay over $100k?

In upstream process development, senior roles such as Process Development Managers, Principal Scientists, and Regulatory Affairs Directors often have salaries exceeding $100,000. These positions typically require advanced degrees, extensive industry experience, and expertise in bioprocessing, quality control, or regulatory compliance.

What is the difference between Upstream Process Development vs Downstream Process Development?

AspectUpstream Process DevelopmentDownstream Process Development
FocusDevelopment of cell culture, fermentation, and bioreactor processesPurification, filtration, and formulation of bioproducts
Skills & CredentialsBioprocess engineering, molecular biology, biochemistryBioprocessing, chromatography, analytical chemistry
Work EnvironmentLaboratories, bioreactors, pilot plantsPurification facilities, labs, quality control
Industry UsageBiotech, pharmaceutical manufacturingBiotech, pharmaceutical manufacturing

Upstream Process Development focuses on creating and optimizing cell culture and fermentation processes to produce bioproducts. In contrast, Downstream Process Development involves purifying and finishing these products. Both roles are essential in biopharmaceutical manufacturing and require similar scientific backgrounds, but they specialize in different stages of bioprocessing.

What is upstream process development?

Upstream process development involves designing and optimizing the initial stages of biopharmaceutical production, such as cell culture and fermentation, to produce target biological products. It requires knowledge of bioprocessing, cell biology, and often involves working with bioreactors and process control systems to ensure consistent, high-quality output.

What are some common challenges faced in upstream process development and how do teams typically address them?

One of the main challenges in upstream process development is optimizing cell culture conditions to consistently achieve high yields and product quality. Teams often encounter variability in biological systems and must troubleshoot issues such as contamination, scale-up inconsistencies, or nutrient limitations. Collaboration with analytical, downstream, and quality teams is essential to identify root causes and implement solutions. Regular data review meetings, cross-functional problem-solving, and continuous process improvement are standard practices to ensure robust upstream processes.
What are popular job titles related to Upstream Process Development jobs in Boston, MA? For Upstream Process Development jobs in Boston, MA, the most frequently searched job titles are:
What job categories do people searching Upstream Process Development jobs in Boston, MA look for? The top searched job categories for Upstream Process Development jobs in Boston, MA are:
What cities near Boston, MA are hiring for Upstream Process Development jobs? Cities near Boston, MA with the most Upstream Process Development job openings:
Upstream Process Development jobs near you
Infographic showing various Upstream Process Development job openings in Boston, MA as of July 2026, with employment types broken down into 1% As Needed, 81% Full Time, 15% Part Time, and 3% Contract. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $59,916 per year, or $28.8 per hour.

Biopharma Manufacturing Associate II

Astellas Pharma, Inc.

Westborough, MA • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 28 days ago

Job description

Biopharma Manufacturing Associate II
About Astellas
Astellas is a global life sciences company committed to turning innovative science into VALUE for patients. We provide transformative therapies in disease areas that include oncology, ophthalmology, urology, immunology and women's health. Through our research and development programs, we are pioneering new healthcare solutions for diseases with high unmet medical need. Learn more at Astellas.com.
Are you driven to make a real difference in the lives of patients?
We're seeking passionate individuals who thrive in dynamic environments, embrace new ideas, and aren't afraid to take intelligent risks. People who act with unwavering integrity and are deeply committed to making a tangible impact.
Purpose & Scope
The Biopharma Manufacturing Associate II will be a key contributor to manufacturing readiness and future operational output of the manufacturing facility. The role will initially support ongoing commissioning and validation activities as the site works towards GMP production readiness and will provide overall manufacturing operations support that includes yet is not limited to; equipment testing, SOP/batch record generation, and validation protocol execution support. Once commissioning and validation is complete, the role will be responsible for executing a combination of engineering and GMP clinical batches with supporting staff. This role, as part of the Manufacturing division, will be an integral contributor tasked with building a diverse and technically strong team for future successful GMP operations.
Role and Responsibilities
  • Perform all manufacturing operations under cGMP/ISO requirements
  • Display understanding of Upstream process theory (e.g., cell thawing, passages, and harvesting) equipment operation, and aseptic processing
  • Assist with the installation, commissioning, and validation of equipment within single use facility
  • Adhere to manufacturing procedures and documentation as well as identifying clarifications or updates when required
  • Perform legible, clear, and concise data entry into batch records, logbooks, and all other ancillary controlled forms used in a cGMP process
  • Maintain a high level of quality and compliance with regards to all aspects of manufacturing
  • Assist/write SOPs (standard operating procedures), batch records, and other GMP documentation
  • Display ability to identify and escalate potential GMP issues, as required
  • Available to participate in flexible shifts (Day, Swing, Weekends, Holidays) as directed by the facility start up and future production schedules
  • Assist in the evaluation and incorporation of new technologies

Required Qualifications
Education:
  • BS / BA in Chemical/ Biological Engineering or Life Sciences or Associate's Degree in science or related field with 1+ years of industry experience.

Experience:
  • Experience in maintaining detailed records and ability to assist in document revisions
  • Experience in cell culture with excellent aseptic technique
  • Strong skill on biological laboratory math
  • Understanding of cGMPS as related to commercial and clinical operations
  • Strong communicator with ability to work effectively both independently and as part of a team • Developing problem-solving skills
  • Strong computer skills including MS Office (Word, Excel) and proven ability to establish and maintain effective working relationships with team members and managers
  • Models our Core Values: Be Bold, Care Deeply, Get Stuff Done - is experienced as someone who exemplifies the culture we want to create; operates with transparency; is trusted
  • Will support and demonstrate quality standards to ensure data of highest quality and will be expected to perform other duties and/or special projects, as assigned

Preferred Qualifications
  • BioWork Certification or related type certifications are a plus along with technical understanding of a biotech manufacturing facility
  • Knowledge of upstream process and aseptic technique
  • Experience with single-use technologies
  • Understanding of FDA regulations
  • Experience with continuous improvement platforms and history of identifying changes with positive impact to safety, product quality, and/or operational efficiency
  • Ability to clearly define events and associated process conditions during nonconformance or safety escalation efforts
  • Ability to multi-task, be flexible and to thrive in a fast-paced environment, as well as the capacity to handle uncertainty and changing priorities

Location and Working Environment
  • This position is based in Westborough, MA and will require on-site work.
  • This role frequently requires long periods of sitting, standing and use of hands and regular motion to include bending, stooping, regular reaching over head activities, and independent mobility to lift to 25lbs.
  • This role supports the cleanroom. Gowning in to the cleanroom is expected.
  • This is a 100% on-site role working in a cGMP regulated manufacturing facility.
  • This roles requires to work in shifts - 4 x 10s, 12 hrs rotating, administrative or 2nd, depending on the business needs. Shift shall be assigned upon recruitment and are subject to change upon hire.
  • Assigned shift schedules is subject to change with or without notice based on critical operational needs.
  • Weekend work is often scheduled to support staffing and operational needs.
  • On occasion, this role may travel to other Astellas Biopharma Manufacturing facilities (0-5%)

What awaits you at Astellas?
  • Global collaboration: Become part of a connected global business of like-minded life science leaders, all dedicated to improving patients' lives worldwide.
  • Real-world patient impact: Contribute to transformative therapies that reach patients around the world, knowing your work makes a difference every day.
  • Relentless Innovation: Join a company at the forefront of scientific breakthroughs, where you'll have the opportunity to shape the future of healthcare.
  • A Culture of Growth: Chart your own course within a supportive environment that values your contributions, champions your development, and empowers you to pursue your passions.

Our Organizational Values and Behaviors
Values: Innovation, Integrity and Impact sit at the heart of what we do.
Behaviors: We come together as 'One Astellas', working with courage and a sense of urgency. We are outcome focused and consistently take accountability for our personal contribution.
Salary Range
$32.38-$46.25 (Final compensation will be determined based on a variety of factors, including but not limited to skills, experience and organizational equity considerations.)
Benefits:
  • Medical, Dental and Vision Insurance
  • Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down
  • 401(k) match and annual company contribution
  • Company paid life insurance
  • Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions
  • Long Term Incentive Plan for eligible positions
  • Company fleet vehicle for eligible positions
  • Referral bonus program

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