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Upstream Process Development Jobs in New York (NOW HIRING)

AK Steel

Process Engineer

Middletown, NJ · On-site

Provide technical expertise in process requirements for development of new products and evaluation ... Interacts with process engineers from various upstream and downstream units to assure expedient ...

Actalent

Associate Scientist

Tarrytown, NY · On-site

Provide analytical support to cross-functional teams such as formulation development, upstream and downstream process development, and manufacturing, contributing data and insights to address drug ...

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Upstream Process Development information

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$29

$41

How much do upstream process development jobs pay per hour?

As of Jul 14, 2026, the average hourly pay for upstream process development in New York is $29.01, according to ZipRecruiter salary data. Most workers in this role earn between $25.77 and $30.53 per hour, depending on experience, location, and employer.

What jobs pay 500,000 a year in the US?

In the field of Upstream Process Development, senior roles such as Director or Vice President can reach or exceed $500,000 annually, especially with bonuses and stock options. These positions typically require extensive experience, advanced degrees, and leadership skills in biopharmaceutical or biotech industries. High compensation is often associated with managerial responsibilities, strategic decision-making, and overseeing large teams or projects.

What are the key skills and qualifications needed to thrive in Upstream Process Development, and why are they important?

Success in Upstream Process Development requires a strong background in biology, biochemistry, or chemical engineering, often with an advanced degree and experience in cell culture or fermentation techniques. Familiarity with bioreactors, process control systems, and analytical instrumentation, as well as knowledge of cGMP regulations, is essential. Critical thinking, problem-solving, and effective communication are important soft skills for optimizing processes and collaborating across multidisciplinary teams. These competencies ensure efficient development of scalable production processes, maintaining product quality and regulatory compliance.

What are common upstream jobs?

Common upstream process development jobs include roles such as upstream process scientist, bioprocess engineer, and fermentation scientist. These positions focus on developing and optimizing the early stages of biopharmaceutical production, often requiring knowledge of cell culture, bioreactor operation, and process scale-up. Skills in laboratory techniques, process analytical technology, and regulatory compliance are also important in these roles.

What biology jobs pay over $100k?

In upstream process development, senior roles such as Process Development Managers, Principal Scientists, and Regulatory Affairs Directors often have salaries exceeding $100,000. These positions typically require advanced degrees, extensive industry experience, and expertise in bioprocessing, quality control, or regulatory compliance.

What is the difference between Upstream Process Development vs Downstream Process Development?

AspectUpstream Process DevelopmentDownstream Process Development
FocusDevelopment of cell culture, fermentation, and bioreactor processesPurification, filtration, and formulation of bioproducts
Skills & CredentialsBioprocess engineering, molecular biology, biochemistryBioprocessing, chromatography, analytical chemistry
Work EnvironmentLaboratories, bioreactors, pilot plantsPurification facilities, labs, quality control
Industry UsageBiotech, pharmaceutical manufacturingBiotech, pharmaceutical manufacturing

Upstream Process Development focuses on creating and optimizing cell culture and fermentation processes to produce bioproducts. In contrast, Downstream Process Development involves purifying and finishing these products. Both roles are essential in biopharmaceutical manufacturing and require similar scientific backgrounds, but they specialize in different stages of bioprocessing.

What is upstream process development?

Upstream process development involves designing and optimizing the initial stages of biopharmaceutical production, such as cell culture and fermentation, to produce target biological products. It requires knowledge of bioprocessing, cell biology, and often involves working with bioreactors and process control systems to ensure consistent, high-quality output.

What are some common challenges faced in upstream process development and how do teams typically address them?

One of the main challenges in upstream process development is optimizing cell culture conditions to consistently achieve high yields and product quality. Teams often encounter variability in biological systems and must troubleshoot issues such as contamination, scale-up inconsistencies, or nutrient limitations. Collaboration with analytical, downstream, and quality teams is essential to identify root causes and implement solutions. Regular data review meetings, cross-functional problem-solving, and continuous process improvement are standard practices to ensure robust upstream processes.
What are popular job titles related to Upstream Process Development jobs in New York? For Upstream Process Development jobs in New York, the most frequently searched job titles are:
What job categories do people searching Upstream Process Development jobs in New York look for? The top searched job categories for Upstream Process Development jobs in New York are:
Upstream Process Development jobs near you
Infographic showing various Upstream Process Development job openings in New York as of July 2026, with employment types broken down into 1% As Needed, 82% Full Time, 15% Part Time, and 2% Contract. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $60,337 per year, or $29 per hour.

Global Viral Vector MSAT Lead

Legend Biotech US

Raritan, NJ • Hybrid

Other

Re-posted 18 days ago

Job description

Legend Biotech is seeking a Global Viral Vector MSAT Lead as part of the Global Manufacturing & Supply team based in Raritan, NJ. 

Role Overview

The Senior Manager, MSAT - Viral Vector Lead for global In Vivo platforms provides technical leadership and execution oversight for viral vector manufacturing supporting in vivo programs across clinical development and commercial lifecycle management. This role ensures robust, scalable, and compliant manufacturing processes for viral vector platforms that can be transferred to internal or external sites. This role requires collaboration and partnering closely with Process Development, Manufacturing, Quality, Regulatory, and Supply Chain teams to enable reliable clinical supply and future commercialization.

Key Responsibilities

  • Lead MSAT technical support for clinical and late-stage GMP manufacturing of viral vectors for in vivo platforms.
  • Own end-to-end process knowledge for assigned viral vector platforms, including upstream production, downstream purification, formulation, and fill/finish interfaces.
  • Lead technology transfer of viral vector processes from Process Development into GMP manufacturing, including internal sites and external CDMOs.
  • Serve as the primary MSAT technical lead for deviations, root cause investigations, risk assessments, and CAPA execution.
  • Drive process characterization, control strategy development, continued process verification (CPV), and performance trending.
  • Partner cross-functionally to identify and mitigate manufacturing, scale-up, and comparability risks to ensure supply continuity.
  • Provide MSAT technical input to CMC regulatory submissions, health authority interactions, and inspection readiness.
  • Lead, mentor, and develop a team of MSAT scientists and engineers.
  • Drives justification and alignment with key partners (ie. JnJ).

Requirements

  • B.S. required, in technical discipline: biology, engineering, science, or related field.
  • Minimum 10 years of in MSAT, tech transfer or process development.
  • Industrial biologics CMC development or manufacturing experience, CAR-T experience is highly desirable.
  • Experience in cell therapy commercial cGMP program with end-to-end know-how to manage process platform changes/improvements in a global manufacturing network and change management process.
  • Candidate must have extensive experience in Cell Therapy tech transfer and/or MSAT.
  • Experience in a cross functional CMC team as a technical representative driving global commercial programs in cell therapy.
  • Experience as a technical owner in reviewing regulatory submission sections, responding to agency audits.
  • Experience in implementing and managing new commercial processes, improvements and changes.
  • Experience in driving consistency across multiple manufacturing sites.
  • Experience in collaborating with external partners and CMOs preferred.
  • Extensive knowledge in process development, technology transfer, process comparability, CMC regulatory guidelines, process monitoring and manufacturing operations support.
  • Ability to think critically and demonstrated troubleshooting and problem-solving skills.
  • Results driven with strong analytical, problem solving and critical thinking skills.
  • Strong experience working in a cross-functional organization with multiple partners with competing priorities.
  • Ability to plan, multitask, prioritize and be an effective and influential decision maker focused on action and implementation.

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