1

Upstream Process Development Jobs in New Hampshire

4.3. Senior Production Engineer

Exeter, NH · On-site

$92K - $126K/yr

Partner with R&D, materials, and chemical engineering teams to integrate upstream and downstream processes * Champion a culture of continuous improvement, safety, and accountability across the ...

Principal Software Engineer

Portsmouth, NH · Hybrid

$137K - $184K/yr

... application development and onboarding of repfacing experiences. In this role, you'll shape ... Develop a deep understanding of upstream and downstream systems to maintain endtoend data quality ...

Showing results 21-36

Upstream Process Development information

What are the key skills and qualifications needed to thrive in upstream process development?

Success in Upstream Process Development requires a strong background in biology, biochemistry, or chemical engineering, often with an advanced degree and experience in cell culture or fermentation techniques. Familiarity with bioreactors, process control systems, and analytical instrumentation, as well as knowledge of cGMP regulations, is essential. Critical thinking, problem-solving, and effective communication are important soft skills for optimizing processes and collaborating across multidisciplinary teams. These competencies ensure efficient development of scalable production processes, maintaining product quality and regulatory compliance.

What are some common challenges faced in upstream process development and how do teams typically address them?

One of the main challenges in upstream process development is optimizing cell culture conditions to consistently achieve high yields and product quality. Teams often encounter variability in biological systems and must troubleshoot issues such as contamination, scale-up inconsistencies, or nutrient limitations. Collaboration with analytical, downstream, and quality teams is essential to identify root causes and implement solutions. Regular data review meetings, cross-functional problem-solving, and continuous process improvement are standard practices to ensure robust upstream processes.

What is the difference between Upstream Process Development vs Downstream Process Development?

AspectUpstream Process DevelopmentDownstream Process Development
FocusDevelopment of cell culture, fermentation, and bioreactor processesPurification, filtration, and formulation of bioproducts
Skills & CredentialsBioprocess engineering, molecular biology, biochemistryBioprocessing, chromatography, analytical chemistry
Work EnvironmentLaboratories, bioreactors, pilot plantsPurification facilities, labs, quality control
Industry UsageBiotech, pharmaceutical manufacturingBiotech, pharmaceutical manufacturing

Upstream Process Development focuses on creating and optimizing cell culture and fermentation processes to produce bioproducts. In contrast, Downstream Process Development involves purifying and finishing these products. Both roles are essential in biopharmaceutical manufacturing and require similar scientific backgrounds, but they specialize in different stages of bioprocessing.

What are common upstream process development jobs?

Common upstream process development jobs include roles such as upstream process scientist, process engineer, and bioprocess development specialist. These positions focus on optimizing cell culture, fermentation, and bioreactor processes to improve product yield and quality, often requiring knowledge of bioreactor operation, cell biology, and process scale-up. Skills in laboratory techniques, process modeling, and regulatory compliance are also important in these roles.

What is an upstream process development job?

An upstream process development job involves designing, optimizing, and scaling the early stages of biopharmaceutical production, such as cell culture and fermentation processes. Professionals in this role typically work with bioreactors, laboratory equipment, and process analytical tools to improve yield and quality of biological products. Strong knowledge of microbiology, biochemistry, and process engineering is essential, along with adherence to regulatory standards.

What are popular job titles related to Upstream Process Development jobs in New Hampshire?

For Upstream Process Development jobs in New Hampshire, the most frequently searched job titles are:

What job categories do people searching Upstream Process Development jobs in New Hampshire look for?

The top searched job categories for Upstream Process Development jobs in New Hampshire are:

Infographic showing various Upstream Process Development job openings in New Hampshire as of September 2026, with employment types broken down into 1% Internship, 1% As Needed, 84% Full Time, 12% Part Time, and 2% Contract. Highlights an 86% Physical, 2% Hybrid, and 12% Remote job distribution.

4.3. Senior Production Engineer

Exeter, NH • On-site

Phoenix Tailings
Coal, Metals and Minerals Mining • 11 - 50 employees

$92K - $126K/yr

Other

Medical, Dental, Vision, PTO

Posted 14 days ago


Job description

About Phoenix Tailings

Phoenix Tailings is a rapidly-growing clean mining and metals production startup dedicated to sustainable and economic critical metals production. Our mission is to be the world's first fully clean mining and metals production company, producing the resources needed for the next generation of our economy.

Why Phoenix Tailings

At Phoenix Tailings, we believe that nothing great is ever accomplished alone or without the passion of people who push and motivate one another. If you are someone who shares our relentless pursuit of a better future, passion for innovation, and are excited about working with some of the top innovators in the world, then this is the place for you.

Our Values:
  • You are only crazy if you are wrong, it's ok to be wrong
  • Lead with Compassion
  • Be Resourceful
  • Listen
  • Hustle
Who We Are Looking For:

Phoenix Tailings is looking for a hands-on, experienced, and mission-driven Senior Production Engineer to help launch and scale our first commercial rare earth metal production facility in Exeter, NH. You'll help to scale our next-generation systems rare earth metal refining processes and enabling safe, consistent, and high-performance operation. You'll work directly on the floor with operators, engineers, and plant leadership to turn breakthrough innovation into industrial reality - producing the rare earth and critical metals that power the modern world.

Key Responsibilities:
  • Operate and optimize next-generation metal production systems to achieve throughput, yield, and quality targets
  • Drive root-cause investigations and corrective actions for process deviations or equipment issues
  • Lead data-driven improvement efforts to reduce downtime, increase throughput, and ensure process reliability
  • Scale pilot metal recovery processes into full commercial production lines with minimal disruption
  • Develop and refine SOPs, process documentation, and training materials to enable safe and repeatable operations
  • Support process commissioning and startup for new systems and upgrades in Exeter
  • Mentor operators and junior engineers, building operational excellence and a strong safety culture
  • Serve as the technical point of contact for day-to-day production issues and escalations
  • Partner with R&D, materials, and chemical engineering teams to integrate upstream and downstream processes
  • Champion a culture of continuous improvement, safety, and accountability across the facility
Qualifications:
  • B.S. or M.S. in Mechanical Engineering, Chemical Engineering, Materials Science, or related field
  • 4-7 years of experience in production, process, or manufacturing engineering - ideally in heavy industry or chemical processing
  • Proven ability to lead hands-on process troubleshooting, improvement initiatives, and equipment optimization
  • Strong mechanical aptitude with experience operating and improving industrial-scale systems
  • Proficient in analyzing production data and translating insights into actionable improvements
  • Comfortable working on a production floor environment and supporting rotating shift teams as needed
  • Able to work independently in fast-paced, ambiguous situations with a strong sense of ownership
  • Abie to lift up to 50 lbs
  • Able to wear a respirator for extended periods of time
We offer a competitive compensation package that is based on expertise. We also offer the following benefits:
  • Healthcare: 100% Medical, dental, and vision coverage for employee
  • Stock Options: Ownership in a fast-growing venture-backed company.
  • Time Off: Unlimited PTO.
  • Learning: Learning and development opportunities to grow your skills and career.
  • Great team: Working with fun, hard-working, kind people committed to making a difference!

At Phoenix Tailings, we have an open culture that values learning, and we are looking to grow the team with enthusiastic individuals who share our vision of sustainable mining.

Phoenix Tailings, Inc. is an Equal Opportunity Employer, and we value diversity at all levels. All qualified candidates will receive consideration for employment without regard to race, color, religion, sex (including gender identity, sexual orientation, and pregnancy), national origin, age, disability or genetic information, or any other applicable protected characteristics, and these characteristics will not be a factor for consideration of any work-related decisions (including but not limited to hiring, firing, compensation, and discipline).

#J-18808-Ljbffr