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Upstream Process Development Jobs in California (NOW HIRING)

Syner-G

Staff Process Engineer

Tustin, CA · On-site

  • PTO

Support technology transfer strategy development, technical readiness assessments, process fit-gap ... Extensive expertise in upstream and downstream biologics manufacturing processes, including ...

GeneFab

Senior Process Engineer, MSAT

Alameda, CA · On-site

$117K - $152K/yr

Lead the GMP implementation of internal platform processes for cell and gene therapy modalities, including upstream and downstream unit operations. * Collaborate closely with Process Development to ...

GeneFab

Senior Process Engineer, MSAT

Alameda, CA

$117K - $152K/yr

Lead the GMP implementation of internal platform processes for cell and gene therapy modalities, including upstream and downstream unit operations. * Collaborate closely with Process Development to ...

GeneFab

Senior Process Engineer, MSAT

Alameda, CA

$72 - $89/hr

Lead the GMP implementation of internal platform processes for cell and gene therapy modalities, including upstream and downstream unit operations. * Collaborate closely with Process Development to ...

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Upstream Process Development information

What are the key skills and qualifications needed to thrive in upstream process development?

Success in Upstream Process Development requires a strong background in biology, biochemistry, or chemical engineering, often with an advanced degree and experience in cell culture or fermentation techniques. Familiarity with bioreactors, process control systems, and analytical instrumentation, as well as knowledge of cGMP regulations, is essential. Critical thinking, problem-solving, and effective communication are important soft skills for optimizing processes and collaborating across multidisciplinary teams. These competencies ensure efficient development of scalable production processes, maintaining product quality and regulatory compliance.

What is the difference between Upstream Process Development vs Downstream Process Development?

AspectUpstream Process DevelopmentDownstream Process Development
FocusDevelopment of cell culture, fermentation, and bioreactor processesPurification, filtration, and formulation of bioproducts
Skills & CredentialsBioprocess engineering, molecular biology, biochemistryBioprocessing, chromatography, analytical chemistry
Work EnvironmentLaboratories, bioreactors, pilot plantsPurification facilities, labs, quality control
Industry UsageBiotech, pharmaceutical manufacturingBiotech, pharmaceutical manufacturing

Upstream Process Development focuses on creating and optimizing cell culture and fermentation processes to produce bioproducts. In contrast, Downstream Process Development involves purifying and finishing these products. Both roles are essential in biopharmaceutical manufacturing and require similar scientific backgrounds, but they specialize in different stages of bioprocessing.

What are some common challenges faced in upstream process development and how do teams typically address them?

One of the main challenges in upstream process development is optimizing cell culture conditions to consistently achieve high yields and product quality. Teams often encounter variability in biological systems and must troubleshoot issues such as contamination, scale-up inconsistencies, or nutrient limitations. Collaboration with analytical, downstream, and quality teams is essential to identify root causes and implement solutions. Regular data review meetings, cross-functional problem-solving, and continuous process improvement are standard practices to ensure robust upstream processes.

What are popular job titles related to Upstream Process Development jobs in California?

For Upstream Process Development jobs in California, the most frequently searched job titles are:

What job categories do people searching Upstream Process Development jobs in California look for?

The top searched job categories for Upstream Process Development jobs in California are:

What cities in California are hiring for Upstream Process Development jobs?

Cities in California with the most Upstream Process Development job openings:

Upstream Process Development jobs near you
Infographic showing various Upstream Process Development job openings in California as of August 2026, with employment types broken down into 1% As Needed, 81% Full Time, 14% Part Time, 2% Temporary, and 2% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution.

Senior/Staff Process Engineer (Flip Chip)

Doist

San Jose, CA • On-site

$140 - $190/hr

Other

Posted 5 days ago

Job description

# Senior/Staff Process Engineer (Flip Chip)Lumilens • San Jose, CA • • 2h agoSave this role or tell us whether you want more jobs like it.**Core Responsibilities**1. Owns the process development and technical support of the Flip Chip process for silicon photonic chip wafers, with OSAT or internal line. Process may include plasma cleaning, flux engineering, pick & place, reflow, underfill, curing and/or TCB/NCP flux-less flow.2. DOE to characterize process window and margin. Optimize process integration with upstream processes (e.g. bump/FO) to increase yield and manufacturability.3. Material Characterization & Selection: Evaluate and qualify new manufacturing raw materials, including NCP, flux, underfill etc, as applicable.4. Design and execute DOE plans to characterize thermal and mechanical stress. Lead reliability validations including Temperature Cycling Test (TCT), Unbiased Highly Accelerated Stress Test (HAST) and High-Temperature Storage (HTS).5. Failure Analysis & Debug: Own the root-cause diagnostics of structural failure modes unique to FC (e.g. flux void, residue, misalignment, die warpage, reflow anomaly, underfill void etc), and formulate improvement solutions.6. Manage incoming material quality control, establish SPC control plans and monitor process variation to ensure long-term process stability.7. Compile process SOP, WI, process failure reports and engineering change documents; support NPI new product introduction and process verification.**Key Requirements & Qualifications*** Education: Bachelor or Master degree in Materials Science, Chemical Engineering, Mechanical Engineering, Microelectronics, or an equivalent technical discipline.* Experience: 5+ years of hands-on industry experience in flip chip assembly.* Technical Knowledge:* Deep practical understanding of plasma cleaning, flux engineering, pick & place, reflow, underfill, curing and/or TCB/NCP flux-less flow.* Comprehensive command of finite element simulation principles regarding warpage, thermal dissipation, and structural mechanical integrity.* Solid working expertise with industry validation methodologies including FMEA, SPC controls, and structured 8D problem-solving tools.* Software Tools: High proficiency with robust analytical platforms like JMP, Minitab. #J-18808-Ljbffr

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