ZipRecruiter

Log In

1

Trial Master File Jobs in Boston, MA (NOW HIRING)

Verastem

Clinical Trial Manager

Boston, MA · On-site

$100K - $125K/yr

Assume responsibility for setting up trial master file and ensuring the trial(s) is "audit ready" at all times. * Review, complete and ensure implementation of corrective action plans in conjunction ...

PROMETRIKA, LLC

Clinical Trial Manager

Cambridge, MA · On-site

Manage the operational aspects of clinical trials (e.g., study management, site monitoring and management, trial master file (TMF) oversight,) * Coordinate and support regulatory submissions and ...

Lumicell

Senior Clinical Trial Manager

Waltham, MA · On-site

Trial Master File and inspection readiness * Maintain oversight of study TMF completeness and quality. * Ensure essential study documents are filed throughout the study lifecycle. * Coordinate TMF ...

Lumicell

Senior Clinical Trial Manager

Waltham, MA · On-site

Trial Master File and inspection readiness * Maintain oversight of study TMF completeness and quality. * Ensure essential study documents are filed throughout the study lifecycle. * Coordinate TMF ...

Lumicell

Senior Clinical Trial Manager

Waltham, MA · On-site

Trial Master File and inspection readiness * Maintain oversight of study TMF completeness and quality. * Ensure essential study documents are filed throughout the study lifecycle. * Coordinate TMF ...

Lumicell

Senior Clinical Trial Manager

Waltham, MA · On-site

$130 - $180/hr

Trial Master File and inspection readiness * Maintain oversight of study TMF completeness and quality. * Ensure essential study documents are filed throughout the study lifecycle. * Coordinate TMF ...

Dyne Therapeutics

Senior Clinical Trial Associate

Waltham, MA · On-site

$36.25 - $49.25/hr

Collect, file, reconcile, and track essential documents for the trial master file (TMF); conduct routine TMF reviews, identify gaps, follow up on missing documentation, and support ongoing inspection ...

Prometrika, Llc

Clinical Trial Manager

Cambridge, MA · On-site

$140 - $168/hr

Manage the operational aspects of clinical trials (e.g., study management, site monitoring and management, trial master file (TMF) oversight) * Coordinate and support regulatory submissions and ...

Prometrika LLC

Clinical Trial Manager

Cambridge, MA · On-site

$140K - $168K/yr

Manage the operational aspects of clinical trials (e.g., study management, site monitoring and management, trial master file (TMF) oversight,) * Coordinate and support regulatory submissions and ...

Verastem

Clinical Trial Associate

Boston, MA · On-site

$86K - $100K/yr

Manages trial related documents in the Veeva Vault Trial Master File (TMF); manages user access and facilitate training for internal/external users as needed; trains new users. * Uploads and reviews ...

WHOOP

Director, Clinical Operations

Boston, MA · On-site

$210 - $230/hr

Deep expertise in clinical trial execution, study startup, participant recruitment, monitoring, enrollment, clinical data management, trial master file oversight, and study closeout activities.

previous page

Showing results 41-60

All JobsTrial Master File JobsTrial Master File Jobs in Boston, MA

Trial Master File information

See Boston, MA salary details

$12

$42

$83

How much do trial master file jobs pay per hour?

As of Sep 5, 2026, the average hourly pay for trial master file in Boston, MA is $42.52, according to ZipRecruiter salary data. Most workers in this role earn between $27.53 and $51.72 per hour, depending on experience, location, and employer.

What is a trial master file?

A Trial Master File (TMF) job involves managing and maintaining essential documents related to clinical trials to ensure compliance with regulatory requirements. Professionals in this role organize, track, and audit critical trial documentation to support inspections and submissions. They work closely with clinical teams, sponsors, and regulatory authorities to ensure proper documentation is accurate, complete, and audit-ready throughout the trial lifecycle.

What are the typical responsibilities and daily tasks of a trial master file specialist?

As a TMF Specialist, your main responsibilities include managing, organizing, and maintaining all essential clinical trial documentation to ensure compliance with regulatory standards. On a daily basis, you will review and upload documents to eTMF systems, track document status, resolve discrepancies, and support study teams during audits or inspections. You'll collaborate closely with clinical research associates, project managers, and quality assurance teams to ensure the TMF is complete and inspection-ready at all times. The work is detail-oriented and deadline-driven, offering opportunities to develop expertise in regulatory standards and advance into roles such as TMF Manager or Clinical Trial Associate.

What are the key skills and qualifications needed to thrive in the trial master file position, and why are they important?

To thrive in a Trial Master File (TMF) Specialist role, you need meticulous organizational skills, comprehensive knowledge of regulatory requirements for clinical trials, and often a bachelor's degree in life sciences or a related field. Familiarity with electronic Trial Master File (eTMF) systems, document management platforms, and relevant GCP (Good Clinical Practice) certifications is commonly required. Attention to detail, proactive communication, and the ability to collaborate effectively across clinical research teams are key soft skills. These competencies ensure regulatory compliance and seamless documentation, which are critical for the successful conduct and audit-readiness of clinical trials.

What are the most commonly searched types of Trial Master File jobs in Boston, MA?

The most popular types of Trial Master File jobs in Boston, MA are:

What are popular job titles related to Trial Master File jobs in Boston, MA?

For Trial Master File jobs in Boston, MA, the most frequently searched job titles are:

What job categories do people searching Trial Master File jobs in Boston, MA look for?

The top searched job categories for Trial Master File jobs in Boston, MA are:

What cities near Boston, MA are hiring for Trial Master File jobs?

Cities near Boston, MA with the most Trial Master File job openings:

Trial Master File jobs near you
Infographic showing various Trial Master File job openings in Boston, MA as of August 2026, with employment types broken down into 1% Internship, 1% As Needed, 82% Full Time, 12% Part Time, and 4% Contract. Highlights an 89% Physical, 3% Hybrid, and 8% Remote job distribution, with an average salary of $88,441 per year, or $42.5 per hour.

Clinical Trial Manager

Verastem

Boston, MA • On-site

$100K - $125K/yr

Full-time

Re-posted 5 days ago

Job description

Summary:
We are seeking a Clinical Trial Manager with experience in managing a global Phase 3 clinical trial. Works with senior Clinical Operations members to lead the clinical project team members in the selection of vendors along with overseeing the completion of deliverables in a timely fashion within an agreed upon project budget. General areas of responsibility include: project planning, initiation, implementation, and closure; leading and motivating a cross functional team; milestone planning and tracking; ensuring that projects are progressing according to quality standards, Standard Operating Procedures (SOPs), Good Clinical Practice (GCP) guidelines, and/or other guidelines to fulfill local regulations; production and review of key project progress reports; management of communications between the project team and CROs and ancillary vendors; and contract and financial management.
Responsibilities:
  • Function as primary liaison between clinical vendors (CRO, IRT, eTMF) and Verastem Oncology to ensure understanding of expectations and scope of work, quality and budget. Proactively recognize any changes in SOW and work with CRO to manage accruals and SOW changes.
  • Manage assigned clinical trials to ensure that studies are conducted efficiently, on time, within budget and in accordance with established SOPs and applicable regulatory requirements.
  • Provide oversight of all elements of the project lifecycle from initial set-up to close out including vendor performance, internal metrics, quality assurance checks and communication of trial status.
  • Work with Senior Clinical Operations member on RFPs for distribution to vendors, review proposals, coordinate bid defenses and internal discussions in selecting vendors to maximize savings.
  • Negotiate master service agreements, work orders, contracts, and amendments for sites/vendors.
  • Assist in developing study-specific feasibilities and participate in site selection.
  • Contribute to the writing and/or review of clinical documents such as Protocols, Informed Consent Forms, case report forms (CRFs) design and completion guidelines, and other study-related documents.
  • Liaise with medical monitor and cross functional team members as necessary and in accordance with established SOPs to produce study deliverables (e.g., clinical protocols, CRFs, informed consent templates, project management plan, data management plan, safety management plan, medical monitoring plan, clinical monitoring plan, pharmacy/lab manuals, clinical study reports etc.).
  • Work closely with Data Management to ensure ongoing data cleaning including review of data management metric, review of patient profiles and data listings.
  • Work with CRO and/or core team members to address issues and risks associated with achieving the study deliverables and develop risk mitigation plan.
  • Oversee monitoring activities at clinical CROs by reviewing monitoring visit reports, protocol deviations and CAPAs; attend co-monitoring visits as required.
  • Chair cross functional study team meetings and maintain meeting minutes and action items for team follow-up.
  • Regularly meet with Manager to discuss overall clinical trial(s) plans, update forecasting, and identify potential issues with recommended solutions.
  • Identify issues and implement solutions to ensure the project remains on track; recognize the need to seek assistance or inform senior management of specific issues.
  • Assume responsibility for setting up trial master file and ensuring the trial(s) is "audit ready" at all times.
  • Review, complete and ensure implementation of corrective action plans in conjunction with manager and quality assurance at vendor(s), and individual site(s) as applicable. May participate in internal/external study related audit(s).
  • Update assigned tracking spreadsheets on an ongoing basis.
  • Work with Finance to forecast budgets and reconcile monthly/quarterly actuals versus actuals.
  • Work with Quality Assurance to create and update clinical SOPs.

Qualifications:
  • Global Phase 3 clinical trial management experience
  • Minimum of 3 years of clinical trial experience, including prior experience in oncology clinical studies. BA/BS degree or equivalent in a scientific or health care field is required.
  • Excellent understanding of ICH, GCP and other applicable regulatory guidelines required.
  • Excellent verbal and written communication skills to effectively communicate with site staff, vendors and internal cross functional team members.
  • Ability to prioritize and multi- task.
  • Travel may be required.

The base salary range ($100K - $125K) provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, location, and market dynamics. In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.

Apply