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Trial Master File Jobs in Boston, MA (NOW HIRING)

Verastem

Clinical Trial Manager

Boston, MA

$100K - $125K/yr

Assume responsibility for setting up trial master file and ensuring the trial(s) is "audit ready" at all times. * Review, complete and ensure implementation of corrective action plans in conjunction ...

Alpha-9 Oncology

Clinical Trial Manager

Boston, MA

Responsible for maintaining internal study documents in the Trial Master File (TMF) and periodically reviewing the CRO TMF for completeness and accuracy. * Support forecasting and management of ...

Verastem

Clinical Trial Manager

Boston, MA · On-site

$100K - $125K/yr

Assume responsibility for setting up trial master file and ensuring the trial(s) is "audit ready" at all times. * Review, complete and ensure implementation of corrective action plans in conjunction ...

Dyne Therapeutics

Senior Clinical Trial Associate

Waltham, MA · On-site

$36.25 - $49.25/hr

Collect, file, reconcile, and track essential documents for the trial master file (TMF); conduct routine TMF reviews, identify gaps, follow up on missing documentation, and support ongoing inspection ...

Lumicell

Senior Clinical Trial Manager

Waltham, MA · On-site

Trial Master File and inspection readiness * Maintain oversight of study TMF completeness and quality. * Ensure essential study documents are filed throughout the study lifecycle. * Coordinate TMF ...

Lumicell

Senior Clinical Trial Manager

Waltham, MA · On-site

Trial Master File and inspection readiness * Maintain oversight of study TMF completeness and quality. * Ensure essential study documents are filed throughout the study lifecycle. * Coordinate TMF ...

New

Lumicell

Senior Clinical Trial Manager

Waltham, MA

Trial Master File and inspection readiness * Maintain oversight of study TMF completeness and quality. * Ensure essential study documents are filed throughout the study lifecycle. * Coordinate TMF ...

Dyne Therapeutics

Senior Clinical Trial Associate

Waltham, MA · On-site

$36.25 - $49.25/hr

Collect, file, reconcile, and track essential documents for the trial master file (TMF); conduct routine TMF reviews, identify gaps, follow up on missing documentation, and support ongoing inspection ...

Prometrika LLC

Clinical Trial Manager

Cambridge, MA · On-site

$140K - $168K/yr

Manage the operational aspects of clinical trials (e.g., study management, site monitoring and management, trial master file (TMF) oversight,) * Coordinate and support regulatory submissions and ...

Verastem

Clinical Trial Associate

Boston, MA · On-site

$86K - $100K/yr

Manages trial related documents in the Veeva Vault Trial Master File (TMF); manages user access and facilitate training for internal/external users as needed; trains new users. * Uploads and reviews ...

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Showing results 21-40

All JobsTrial Master File JobsTrial Master File Jobs in Boston, MA

Trial Master File information

See Boston, MA salary details

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$42

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How much do trial master file jobs pay per hour?

As of Aug 9, 2026, the average hourly pay for trial master file in Boston, MA is $42.52, according to ZipRecruiter salary data. Most workers in this role earn between $27.53 and $51.72 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the trial master file position, and why are they important?

To thrive in a Trial Master File (TMF) Specialist role, you need meticulous organizational skills, comprehensive knowledge of regulatory requirements for clinical trials, and often a bachelor's degree in life sciences or a related field. Familiarity with electronic Trial Master File (eTMF) systems, document management platforms, and relevant GCP (Good Clinical Practice) certifications is commonly required. Attention to detail, proactive communication, and the ability to collaborate effectively across clinical research teams are key soft skills. These competencies ensure regulatory compliance and seamless documentation, which are critical for the successful conduct and audit-readiness of clinical trials.

What is a trial master file?

A Trial Master File (TMF) job involves managing and maintaining essential documents related to clinical trials to ensure compliance with regulatory requirements. Professionals in this role organize, track, and audit critical trial documentation to support inspections and submissions. They work closely with clinical teams, sponsors, and regulatory authorities to ensure proper documentation is accurate, complete, and audit-ready throughout the trial lifecycle.

What are the typical responsibilities and daily tasks of a trial master file specialist?

As a TMF Specialist, your main responsibilities include managing, organizing, and maintaining all essential clinical trial documentation to ensure compliance with regulatory standards. On a daily basis, you will review and upload documents to eTMF systems, track document status, resolve discrepancies, and support study teams during audits or inspections. You'll collaborate closely with clinical research associates, project managers, and quality assurance teams to ensure the TMF is complete and inspection-ready at all times. The work is detail-oriented and deadline-driven, offering opportunities to develop expertise in regulatory standards and advance into roles such as TMF Manager or Clinical Trial Associate.

What are the most commonly searched types of Trial Master File jobs in Boston, MA? The most popular types of Trial Master File jobs in Boston, MA are:
What are popular job titles related to Trial Master File jobs in Boston, MA? For Trial Master File jobs in Boston, MA, the most frequently searched job titles are:
What job categories do people searching Trial Master File jobs in Boston, MA look for? The top searched job categories for Trial Master File jobs in Boston, MA are:
What cities near Boston, MA are hiring for Trial Master File jobs? Cities near Boston, MA with the most Trial Master File job openings:
Trial Master File jobs near you
Infographic showing various Trial Master File job openings in Boston, MA as of August 2026, with employment types broken down into 1% As Needed, 82% Full Time, 13% Part Time, and 4% Contract. Highlights an 90% Physical, 2% Hybrid, and 8% Remote job distribution, with an average salary of $88,441 per year, or $42.5 per hour.

Clinical Trial Manager II

Odyssey Therapeutics, Inc.

Boston, MA • On-site

$120K - $180K/yr

Full-time

Re-posted 7 days ago

Job description

Odyssey Therapeutics is propelling drug development beyond what is now possible to deliver medicines that address critical needs of patients with inflammatory and immunology diseases. We achieve unprecedented speed and efficiency by bringing together a target-centric approach, a toolbox of cutting-edge technologies, and a team of accomplished, world-class drug hunters. By reimagining the drug development process, we are creating a deep and broad drug pipeline that holds the potential to transform human health.
The opportunity:
The Clinical Trial Manager II (CTM II) is responsible for the delivery of all clinical aspects of the study. The CTM II oversees the clinical portion of the budget, develops monitoring plans and tools, train applicable operations team members, drives enrollment and study start-up activities, performs monitoring, liaises with internal and external stakeholders, identifies and mitigates risks that may impact clinical delivery.
Your primary objectives will be:
  • Ensure quality of the trial master file through content (QC) review of submitted documents, applying metadata and finalizing documents and liaise with project teams to resolve any issues identified with submitted documents
  • Provide monitoring oversight including assisting with the development of the clinical monitoring plan, performing study monitoring visits, completing all monitoring documentation in a timely manner
  • Serve as the clinical point person managing protocol execution, including the oversight of assigned vendors and consultants that are involved with the clinical trial
  • Participate in program strategy meetings, ad hoc clinical operations' initiatives and programs
  • Assist in the preparation and review of clinical documentation such as the informed consent, clinical protocols, Investigator's Brochure, and other study documentation
  • Participate in the request and review of scope of works, budgets, vendor performance, and issue resolution
  • Establish study milestone and ensure accurate tracking and reporting of study metrics and timelines
  • Responsible for executing one or more elements of clinical trials in compliance with ICH GCP, SOPs, and local applicable regulations
  • Provide study-specific mentor and training for clinical operation team members
  • Manage direct reports and monitor assigned activities as required

About you:
  • Bachelor's degree in life sciences, health, or other relevant field of study required
  • Minimum 3 years of experience required with at least 1 year as a clinical trial manager
  • Experience in biotech
  • Experience monitoring
  • Strong knowledge and practical application of clinical trial operations
  • Excels in a fast-paced, high-growth company environment with minimal direction and a high degree of independence and is able to adjust workload based on changing priorities
  • Strong skills in collaboration, communication, organization, attention to detail and multi-tasking
  • Demonstrated leadership, problem-solving, conflict resolution, and team building skills
  • Ability to handle multiple projects and utilize judgement to prioritize tasks
  • Expected travel: 25-35%

The pay range for this role is:
120,490 - 180,736 USD per year (Boston)

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