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Trial Master File Jobs in Boston, MA (NOW HIRING)

Verastem

Clinical Trial Associate

Boston, MA · On-site

$36.50 - $49.75/hr

Manages trial related documents in the Veeva Vault Trial Master File (TMF); manages user access and facilitate training for internal/external users as needed; trains new users.

Clinovo

Clinical Trial Manager

Cambridge, MA · On-site

$175K/yr

Maintain complete, accurate, and inspection-ready Trial Master File (TMF) documentation. Study Closeout Activities * Coordinate site closure activities, reconciliation processes, and final study ...

Skyhawk Therapeutics

Clinical Trial Manager

Waltham, MA · On-site +1

$140K - $200K/yr

Responsible for supporting the management, oversight and maintenance of the Trial Master File (TMF) * Contribute to growth and development of clinical operations function via process/SOP review and ...

Skyhawk Therapeutics

Clinical Trial Manager

Waltham, MA · On-site

$140K - $200K/yr

Responsible for supporting the management, oversight and maintenance of the Trial Master File (TMF) * Contribute to growth and development of clinical operations function via process/SOP review and ...

Verastem Oncology

Clinical Trial Manager

Boston, MA · On-site

$100 - $125/hr

Assume responsibility for setting up trial master file and ensuring the trial(s) is "audit ready" at all times. * Review, complete and ensure implementation of corrective action plans in conjunction ...

Verastem

Clinical Trial Manager

Boston, MA

$100K - $125K/yr

Assume responsibility for setting up trial master file and ensuring the trial(s) is "audit ready" at all times. * Review, complete and ensure implementation of corrective action plans in conjunction ...

eGenesis

Senior Clinical Trial Manager

Cambridge, MA · On-site

$142K - $176K/yr

Serve as a point of contact for CRO and clinical site communication * Assist in the set up the Trial Master File (TMF) and ensure appropriate TMF maintenance throughout the trial, including periodic ...

eGenesis

Senior Clinical Trial Manager

Cambridge, MA · On-site

$142K - $176K/yr

Serve as a point of contact for CRO and clinical site communication * Assist in the set up the Trial Master File (TMF) and ensure appropriate TMF maintenance throughout the trial, including periodic ...

eGenesis

Senior Clinical Trial Manager

Cambridge, MA · On-site

$142K - $176K/yr

Serve as a point of contact for CRO and clinical site communication * Assist in the set up the Trial Master File (TMF) and ensure appropriate TMF maintenance throughout the trial, including periodic ...

Alpha-9 Oncology

Clinical Trial Manager

Boston, MA · On-site

Responsible for maintaining internal study documents in the Trial Master File (TMF) and periodically reviewing the CRO TMF for completeness and accuracy. * Support forecasting and management of ...

Dyne Therapeutics

Senior Clinical Trial Associate

Waltham, MA · On-site

$36.25 - $49.25/hr

Collect, file, reconcile, and track essential documents for the trial master file (TMF); conduct routine TMF reviews, identify gaps, follow up on missing documentation, and support ongoing inspection ...

Ipsen

Clinical Trial Administrator

Cambridge, MA · On-site

$67.50 - $99/hr

Set-up, monitoring, verifying and archiving the clinical Trial Master File (TMF):*** In charge of the Ipsen TMF (electronic and/or paper, if applicable) set-up and administration.* Manage the ...

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Trial Master File information

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How much do trial master file jobs pay per hour?

As of Sep 5, 2026, the average hourly pay for trial master file in Boston, MA is $42.52, according to ZipRecruiter salary data. Most workers in this role earn between $27.53 and $51.72 per hour, depending on experience, location, and employer.

What is a trial master file?

A Trial Master File (TMF) job involves managing and maintaining essential documents related to clinical trials to ensure compliance with regulatory requirements. Professionals in this role organize, track, and audit critical trial documentation to support inspections and submissions. They work closely with clinical teams, sponsors, and regulatory authorities to ensure proper documentation is accurate, complete, and audit-ready throughout the trial lifecycle.

What are the typical responsibilities and daily tasks of a trial master file specialist?

As a TMF Specialist, your main responsibilities include managing, organizing, and maintaining all essential clinical trial documentation to ensure compliance with regulatory standards. On a daily basis, you will review and upload documents to eTMF systems, track document status, resolve discrepancies, and support study teams during audits or inspections. You'll collaborate closely with clinical research associates, project managers, and quality assurance teams to ensure the TMF is complete and inspection-ready at all times. The work is detail-oriented and deadline-driven, offering opportunities to develop expertise in regulatory standards and advance into roles such as TMF Manager or Clinical Trial Associate.

What are the key skills and qualifications needed to thrive in the trial master file position, and why are they important?

To thrive in a Trial Master File (TMF) Specialist role, you need meticulous organizational skills, comprehensive knowledge of regulatory requirements for clinical trials, and often a bachelor's degree in life sciences or a related field. Familiarity with electronic Trial Master File (eTMF) systems, document management platforms, and relevant GCP (Good Clinical Practice) certifications is commonly required. Attention to detail, proactive communication, and the ability to collaborate effectively across clinical research teams are key soft skills. These competencies ensure regulatory compliance and seamless documentation, which are critical for the successful conduct and audit-readiness of clinical trials.

What are the most commonly searched types of Trial Master File jobs in Boston, MA?

The most popular types of Trial Master File jobs in Boston, MA are:

What are popular job titles related to Trial Master File jobs in Boston, MA?

For Trial Master File jobs in Boston, MA, the most frequently searched job titles are:

What job categories do people searching Trial Master File jobs in Boston, MA look for?

The top searched job categories for Trial Master File jobs in Boston, MA are:

What cities near Boston, MA are hiring for Trial Master File jobs?

Cities near Boston, MA with the most Trial Master File job openings:

Trial Master File jobs near you
Infographic showing various Trial Master File job openings in Boston, MA as of August 2026, with employment types broken down into 1% Internship, 1% As Needed, 82% Full Time, 12% Part Time, and 4% Contract. Highlights an 89% Physical, 3% Hybrid, and 8% Remote job distribution, with an average salary of $88,441 per year, or $42.5 per hour.

Associate Director, Trial Operations & Budget

AdvanCell

Boston, MA • On-site

$123K - $154K/yr

Full-time

Re-posted 6 days ago

Job description

The Associate Director, Trial Operations & Budget is responsible for supporting the oversight, planning, and execution of clinical trial activities, with a strong emphasis on financial management and operational excellence. This role ensures that clinical operations deliverables related to CROs, vendors, and clinical sites management and oversight, including budgeting, contracting, invoicing, and Trial Master File (TMF) quality and completeness verification-are conducted in alignment with corporate financial and clinical operations SOPs, study protocols, ICH/GCP guidelines, regulatory requirements, and established budget and timelines. Reporting to the VP, Clinical Development and Operations, this position plays a critical role in vendor management, financial stewardship, and the delivery of high-quality, efficient clinical trials.
Key Responsibilities and Duties
Responsibilities will include, but not limited to:
  • Develop, manage, and track site and study budgets in collaboration with CROs and internal Finance partners.
  • Review, reconcile, and approve vendor and CRO invoices against contracts, milestones, and deliverables.
  • Support clinical operations contracting processes, including review of scopes of work, vendor agreements, and amendments.
  • Manage and review change orders, ensuring alignment with scope, timelines, and budget.
  • Generate and maintain purchase orders (POs) in accordance with company processes and study budgets.
  • Support vendor selection, onboarding, and ongoing performance management to ensure adherence to KPIs and contractual commitments.
  • Support oversight of CROs to ensure clinical trials are executed according to timelines, quality standards, and contractual obligations.
  • Conduct and/or oversee quality control of the Trial Master File (TMF) to maintain accuracy and continuous inspection readiness. Monitor TMF completion metrics to ensure timely and comprehensive document completeness.
  • Collaborate closely with cross-functional teams including Finance, Legal, CMC, Pre-clinical to ensure seamless execution of clinical programs.
  • Proactively identify risks in study execution and financial management, and implement mitigation strategies.
  • Support onboarding procedure and training on internal processes for new team members.

Other Responsibilities
  • Adhere to the Company's quality management system processes and policies.
  • Comply with applicable regulatory requirements, policies, and procedures related to financial reporting transparency, Good Clinical Practice (GCP), and Good Documentation Practice (GDP).
  • Other tasks as requested by the VP Clinical Development and Operations.

Essential Skills, Qualifications, Industry and Educational Requirements
  • Strong knowledge of clinical trial conduct, ICH-GCP guidelines, regulatory requirements, and the Sunshine Act.
  • Meticulous attention to detail to ensure accuracy in documentation and financial tracking.
  • Demonstrated ability to manage budgets, forecasting, and financial reconciliation.
  • Flexibility to collaborate across different time zones
  • Experience with TMF processes and inspection readiness standards.
  • Ability to work to timelines and perform effectively in high-pressure environments.
  • Strong organizational, analytical, and problem-solving skills.

Desirable Skills, Qualifications, Industry and Educational Requirements
  • Proven track record in clinical operations delivery within a sponsor or CRO environment.
  • Demonstrated expertise in vendor management, CRO oversight, and contract management.
  • Experience with budgeting tools, CTMS, and eTMF systems.
  • Strong communication and collaboration skills across cross-functional teams.
  • Minimum 6-10 years' experience in clinical operations (depending on level).
  • Bachelor's degree in life sciences required; advanced degree (MSc or higher) preferred.

$123,000 - $154,000 a year

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