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Trial Master File Jobs in Illinois (NOW HIRING)

Synectics Inc

Biomarker Associate

North Chicago, IL

$54.04 - $67.55/hr

Ensure appropriate documents are added to the Trial Master File. Qualifications: * Ph.D. Degree with 2+ years project management, clinical trial experience and biological science background ...

IQVIA

CRA 2, Oncology, IQVIA

Chicago, IL

$87K - $145K/yr

Ensure copies/originals (as required) site documents are available for filing in the Trial Master File (TMF) and verify that the Investigator's Site File (ISF) is maintained in accordance with GCP ...

IQVIA

CRA 2, Oncology, IQVIA

Chicago, IL

$87K - $145K/yr

Ensure copies/originals (as required) site documents are available for filing in the Trial Master File (TMF) and verify that the Investigator's Site File (ISF) is maintained in accordance with GCP ...

Tempus

Director, (GCP) Quality Assurance

Chicago, IL · On-site

$160 - $200/hr

Conduct audits, including Internal, Investigator Site and Trial Master File. * Host and support company regulatory GCP inspections. * Oversee the clinical quality system document control process ...

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How much do trial master file jobs pay per hour?

As of Aug 30, 2026, the average hourly pay for trial master file in Illinois is $34.85, according to ZipRecruiter salary data. Most workers in this role earn between $22.57 and $42.40 per hour, depending on experience, location, and employer.

What is a trial master file?

A Trial Master File (TMF) job involves managing and maintaining essential documents related to clinical trials to ensure compliance with regulatory requirements. Professionals in this role organize, track, and audit critical trial documentation to support inspections and submissions. They work closely with clinical teams, sponsors, and regulatory authorities to ensure proper documentation is accurate, complete, and audit-ready throughout the trial lifecycle.

What are the typical responsibilities and daily tasks of a trial master file specialist?

As a TMF Specialist, your main responsibilities include managing, organizing, and maintaining all essential clinical trial documentation to ensure compliance with regulatory standards. On a daily basis, you will review and upload documents to eTMF systems, track document status, resolve discrepancies, and support study teams during audits or inspections. You'll collaborate closely with clinical research associates, project managers, and quality assurance teams to ensure the TMF is complete and inspection-ready at all times. The work is detail-oriented and deadline-driven, offering opportunities to develop expertise in regulatory standards and advance into roles such as TMF Manager or Clinical Trial Associate.

What are the key skills and qualifications needed to thrive in the trial master file position, and why are they important?

To thrive in a Trial Master File (TMF) Specialist role, you need meticulous organizational skills, comprehensive knowledge of regulatory requirements for clinical trials, and often a bachelor's degree in life sciences or a related field. Familiarity with electronic Trial Master File (eTMF) systems, document management platforms, and relevant GCP (Good Clinical Practice) certifications is commonly required. Attention to detail, proactive communication, and the ability to collaborate effectively across clinical research teams are key soft skills. These competencies ensure regulatory compliance and seamless documentation, which are critical for the successful conduct and audit-readiness of clinical trials.

What are the most commonly searched types of Trial Master File jobs in Illinois?

The most popular types of Trial Master File jobs in Illinois are:

What are popular job titles related to Trial Master File jobs in Illinois?

For Trial Master File jobs in Illinois, the most frequently searched job titles are:

What job categories do people searching Trial Master File jobs in Illinois look for?

The top searched job categories for Trial Master File jobs in Illinois are:

Trial Master File jobs near you
Infographic showing various Trial Master File job openings in Illinois as of August 2026, with employment types broken down into 1% As Needed, 88% Full Time, 9% Part Time, and 2% Contract. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution, with an average salary of $72,494 per year, or $34.9 per hour.

Senior Manager, Companion Diagnostics (CDx)

Tempus

Chicago, IL • On-site

$120K - $165K/yr

Full-time

Re-posted 23 hours ago

Job description

Passionate about precision medicine and advancing the healthcare industry?
Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.
Senior Manager, Companion Diagnostics (CDx)
Tempus is seeking a Sr. Manager, Companion Diagnostics to lead the planning, oversight, and execution of complex Companion Diagnostic (CDx) clinical validation studies for our pharmaceutical partners. This is a critical, long-term resource needed to establish consistent, internal expertise for high-stakes CDx projects. This role will bridge the gap between drug trial requirements and diagnostic validation, ensuring regulatory compliance and timely study completion.
Key Responsibilities
  • Early Scoping & Alignment: Lead the initial scoping and planning of CDx validation projects and contracts, ensuring input from key internal experts, including Tempus Pharma sequencing, QA, CRO, and Regulatory, external IVD consultants, the drug trial sponsor, and others.
  • Protocol and Strategy Development: Lead the development of diagnostic protocols, including translating drug trial strategy into clinical Dx validation strategy, ensuring sound biostatistical approaches, and alignment on clinical data generation & analysis plans.
  • Cross-Functional Collaboration: Work in partnership with Tempus Pharma sequencing, QA, CRO, and Regulatory, external IVD consultants, the drug trial sponsor, and others to provide necessary input and oversight for both internal and external validation work.
  • Study Execution Oversight: Take ownership of the day-to-day management and execution of regulatory-grade CDx clinical studies for major partners.
  • Regulatory & Quality Compliance: Ensure all clinical validation activities meet the requirements for running clinical device studies, including adherence to GCP and regulatory scrutiny.
  • Project Management: Manage project deliveries, ensuring timely completion and appropriate resourcing to meet agreed-upon timelines.

Qualifications
  • A Ph.D. or Masters in a relevant discipline is highly preferred, though equivalent professional experience will be considered.
  • 5 years of demonstrated experience in IVD or medical device development with a minimum of 2 years of experience in clinical study design and execution.
  • Experience with GCP-grade study setup, monitoring, and reporting, including understanding of trial master file documentation and FDA strategies.
  • Proven ability to understand biostatistics strategy and help craft strategic workplans and Statistical Analysis Plans (SAPs) with support from SMEs (biostatistics, IVD consultants) as needed.
  • Familiarity with the distinct requirements and complexities of CDx clinical development, including clinical validation strategies and ensuring that studies are conducted and documented in accordance with good clinical practices and other applicable regulatory requirements.
  • Ability to facilitate clear communication and coordinate resources across internal (Pharma sequencing, QA, CRO, Regulatory, others) and external (IVD consultants, the drug trial sponsor).

$120,000-$165,000
The expected salary range above is applicable if the role is performed from Illinois and may vary for other locations (California, Colorado, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.
We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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