ZipRecruiter

Log In

1

Structural Biology Jobs (NOW HIRING)

next page

Showing results 1-20

All JobsScience JobsStructural Biology Jobs

Structural Biology information

See salary details

$15

$23

$31

How much do structural biology jobs pay per hour?

As of Aug 18, 2026, the average hourly pay for structural biology in the United States is $23.42, according to ZipRecruiter salary data. Most workers in this role earn between $20.19 and $25.72 per hour, depending on experience, location, and employer.

What is structural biology?

A Structural Biology job involves studying the molecular structure and function of biological macromolecules, such as proteins and nucleic acids, to understand their roles in cellular processes. Professionals in this field use techniques like X-ray crystallography, cryo-electron microscopy, and NMR spectroscopy to determine molecular structures. These roles are common in academic research, pharmaceutical development, and biotechnology companies, contributing to drug discovery and disease research.

What does someone working in structural biology do?

Professionals in Structural Biology commonly spend their days designing and conducting experiments to analyze the three-dimensional structures of biological macromolecules using techniques like X-ray crystallography, cryo-EM, or NMR spectroscopy. They often collaborate with interdisciplinary teams—including biochemists, computational modelers, and pharmaceutical researchers—to interpret data and inform research directions. In addition to laboratory work, significant time is dedicated to data analysis, preparing research presentations, and staying up to date with scientific literature. This dynamic environment requires flexibility, technical expertise, and an eagerness to solve complex scientific problems.

What are the key skills and qualifications needed to thrive in structural biology?

To thrive in Structural Biology, you need a strong background in molecular biology, biochemistry, and physics, generally supported by an advanced degree (MS or PhD) in a related field. Proficiency with specialized software for molecular modeling (such as PyMOL or Chimera), as well as hands-on experience with technologies like X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy, is essential. Attention to detail, analytical thinking, and collaborative communication are crucial soft skills in this role. These skills and qualifications are key for accurately determining biomolecular structures and contributing valuable insights to biomedical research and drug discovery.

Is structural biology in demand?

Structural biology is a growing field with demand in pharmaceuticals, biotechnology, and academic research for understanding molecular mechanisms. Professionals in this area often work with techniques like X-ray crystallography, cryo-electron microscopy, and molecular modeling, and strong skills in these methods can enhance job prospects. The field offers opportunities in research institutions, biotech companies, and drug development firms.
More about Structural Biology jobs

What cities are hiring for Structural Biology jobs?

Cities with the most Structural Biology job openings:

What are the most commonly searched types of Structural Biology jobs?

The most popular types of Structural Biology jobs are:

What states have the most Structural Biology jobs?

States with the most job openings for Structural Biology jobs include:

What job categories do people searching Structural Biology jobs look for?

The top searched job categories for Structural Biology jobs are:

Structural Biology jobs near you
Infographic showing various Structural Biology job openings in the United States as of August 2026, with employment types broken down into 89% Full Time, 7% Part Time, 3% Contract, and 1% Nights. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution, with an average salary of $48,717 per year, or $23.4 per hour.

Principal Scientist, Structural Biology

Novartis Farmacéutica

San Diego, CA • On-site

$108.50 - $222.30/hr

Other

Medical, Life, Retirement, PTO

This job post has expired 1 day ago. Applications are no longer accepted.

Job description

Job Title

Principal Scientist – Structural Biology (onsite, San Diego, CA)

Overview

At Novartis, the Protein Sciences group plays a pivotal role in advancing early‑stage drug discovery by enabling deep structural and functional insights into therapeutic targets. Structural Biology is a cornerstone capability, enabling structure‑guided drug discovery for some of the most challenging and high‑impact targets in medicine. This is a unique opportunity to join a world‑class structural biology team within one of the largest and most innovative pharmaceutical companies, with access to state‑of‑the‑art instrumentation and a collaborative environment that empowers meaningful contributions to the discovery and development of life‑changing medicines.

Key Responsibilities
  • Lead and execute protein production and X‑ray crystallography to elucidate protein‑small molecule, protein‑peptide, and/or protein‑protein interactions, supporting drug discovery initiatives.
  • Successfully drive gene‑to‑structure small molecule drug discovery projects.
  • Leverage expertise in protein production and structural biology to characterize structure‑function relationships, investigate novel mechanisms of action, and address complex scientific questions.
  • Collaborate with cross‑functional teams, including protein scientists, biophysicists, chemists, and computational modelers, to facilitate structure‑based drug design.
  • Advance initiatives and drug discovery programs by leveraging innovative approaches, such as AI applications.
Essential Requirements
  • Ph.D. in structural biology, biophysics, biochemistry, or a related field with over 5 years of relevant experience in X‑ray crystallography within either industrial or academic settings.
  • Demonstrated expertise in protein expression across E. coli, insect, and mammalian expression systems, and extensive experience in protein purification and characterization.
  • Proven track record in application of X‑ray crystallography to characterize protein‑ligand and protein‑protein complexes, including crystallization screening, optimization, data processing, structure refinement, and analysis.
  • Outstanding communication skills and strong ability to collaborate within multidisciplinary teams in a fast‑paced, goal‑driven environment.
Desirable Requirements
  • Understanding of AI/ML tools for structural biology.
  • Experience with biochemical assays and biophysical methods.
  • Experience with Cryo‑EM is a plus.
Compensation and Benefits

Salary ranges:
Principal Scientist I: $108,500 – $201,500 per year
Principal Scientist II: $119,700 – $222,300 per year

Final salary offered is determined based on factors such as relevant skills and experience. The offer will be reviewed periodically. The compensation package includes a performance‑based cash incentive and, depending on the level of the role, eligibility for annual equity awards. US‑based employees receive a comprehensive benefits package covering health, life and disability benefits, a 401(k) with company contribution and match, and a generous time‑off package that includes vacation, personal days, holidays and other leaves.

#J-18808-Ljbffr

Apply