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Strain Engineering Jobs (NOW HIRING)

ATUM

Gene Synthesis Research Associate I

Newark, CA · On-site

$33/hr

... and strain engineering. ATUM explores novel applications for synthetic genes and the synergy between efficient gene design and protein optimization technologies. ATUM's tools and solutions are ...

Manus

Fermentation Engineer II

Augusta, GA · On-site

Lead cross-functional project teams involving strain engineering, downstream processing, and manufacturing. * Mentor junior engineers and scientists. * Collaborate with external partners, equipment ...

Bluestem Biosciences

Intern

Omaha, NE · On-site

$14.25 - $19.25/hr

Work on projects that directly contribute to Bluestem's mission, such as developing bio-based chemical markets, downstream separation processes, computational biology tools, or strain engineering ...

Manus Bio

Fermentation Engineer II

Augusta, GA · On-site

Lead cross-functional project teams involving strain engineering, downstream processing, and manufacturing. * Mentor junior engineers and scientists. * Collaborate with external partners, equipment ...

Manus Bio

Fermentation Engineer II

Augusta, GA

Lead cross-functional project teams involving strain engineering, downstream processing, and manufacturing. * Mentor junior engineers and scientists. * Collaborate with external partners, equipment ...

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$75K

$114.3K

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How much do strain engineering jobs pay per year?

As of Jul 17, 2026, the average yearly pay for strain engineering in the United States is $114,331.00, according to ZipRecruiter salary data. Most workers in this role earn between $100,000.00 and $128,500.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the Strain Engineering position, and why are they important?

To excel in Strain Engineering, you typically need a strong background in microbiology, molecular biology, or chemical engineering, along with hands-on experience in genetic manipulation and strain optimization. Familiarity with bioinformatics tools, laboratory automation systems, and quality control protocols is highly valued, and certification in relevant biosafety protocols may be required. Strong problem-solving abilities, effective communication, and collaboration are crucial soft skills in this field. These competencies are important to ensure safe and efficient development of microbial strains for industrial, pharmaceutical, or biotechnology applications.

What are the typical daily responsibilities of a Strain Engineer?

As a Strain Engineer, your daily responsibilities often include designing and executing experiments to engineer new microbial strains, analyzing genetic data, and documenting results for ongoing projects. You’ll collaborate closely with microbiologists, fermentation scientists, and process engineers to optimize strain performance for various applications, such as biopharmaceutical production or biofuel development. Depending on the project stage, your work may also involve troubleshooting experimental outcomes and maintaining laboratory equipment. This collaborative and experimental environment keeps the role dynamic and provides ample opportunities to contribute to innovative solutions.

What is a Strain Engineering job?

A Strain Engineering job involves modifying microbial or cellular strains to optimize their genetic and metabolic pathways for improved performance in biotechnology, pharmaceuticals, or industrial applications. Strain engineers use techniques such as genetic engineering, CRISPR, adaptive evolution, and fermentation optimization to enhance traits like yield, stability, or resistance. They work in research labs, biotech companies, or pharmaceutical firms to develop strains for drug production, biofuel generation, or sustainable materials manufacturing.

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Strain Engineering jobs near you
Infographic showing various Strain Engineering job openings in the United States as of July 2026, with employment types broken down into 94% Full Time, 4% Part Time, and 2% Contract. Highlights an 87% Physical, 3% Hybrid, and 10% Remote job distribution, with an average salary of $114,331 per year, or $55 per hour.

Senior Scientist, Upstream Process Development

Stylus Medicine

Cambridge, MA

$155K - $170K/yr

Other

Re-posted 11 days ago

Job description

About the Role:

Stylus Medicine is seeking an intellectually curious and collaborative Senior Scientist, who will lead the development of upstream microbial fermentation processes as part of our CMC Tech Ops team. This role will be responsible for process definition, development, characterization, scale-up and tech transfer from bench scale to pilot. Working closely with the Research, Preclinical, and Formulation teams, this is a special opportunity to advance the development of transformative in vivo genetic medicines.

Key Responsibilities & Accountabilities:

  • Develop scalable production processes for nucleic acids and recombinant proteins
  • Leverage expertise in fermentation and mammalian cell culture to design, optimize, scale-up and characterize production processes
  • Independently utilize multivariate design of experiment (DoE) approaches to improve productivity and optimize parameters for product quality
  • Drive fermentation platform development and new technology implementation to improve process performance, generation of predictive process models, and enhance process control and robustness
  • Design and implement in-process analytics to improve productivity while reducing process and product derived impurities
  • Maintain and troubleshoot equipment to ensure consistency and continuity of operations
  • Document, analyze and present experimental results internally and externally
  • Partner with CDMOs and provide technology transfer support to facilitate scale up
  • Interface with cross-functional teams to ensure programs are on track and stakeholders' needs are met
  • Maintain accurate and reliable record keeping including database management, batch records, notebooks, and all other pertinent documentation

Qualifications & Skills:

  • PhD in Chemical/Biomedical Engineering, Biochemistry, Pharmaceutical Sciences, or related discipline with >4 years of experience, or BS/MS with >8 years of experience in biopharmaceutical or biotechnology development, including experience in developing scalable fermentation processes for producing plasmid DNA and/or recombinant products
  • In-depth experience and knowledge in fermentation process development, optimization, and process scale-up / scale-down model development
  • Familiarity with strain engineering and biocatalysis
  • Familiarity with performing operations in a cleanroom environment, applying controls to ensure aseptic processing
  • Demonstrated ability to coach and mentor junior researchers
  • Independently motivated and good problem-solving ability
  • Attention to detail and accuracy in developing, reviewing, and following protocols, SOPs, batch records and technology transfer documents is a must
  • Demonstrated ability to work collaboratively across teams to meet project deliverables and timelines
  • Strong communication, decision-making and organizational skills
  • Proficiency with statistical analysis software (e.g., JMP) is highly desired
  • Prior experience partnering with external CDMOs and conducting tech transfers preferred

Pay Range: $155,000 - $170,000

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