The laboratory is moving to a larger involvement in single-cell analyses and spatial transcriptomics and the successful candidate should be prepared to develop knowledge and skills in these areas.
The laboratory is moving to a larger involvement in single-cell analyses and spatial transcriptomics and the successful candidate should be prepared to develop knowledge and skills in these areas.
Spatial Transcriptomics information
What is spatial transcriptomics?
Spatial transcriptomics is an advanced technique that allows scientists to measure gene expression within the spatial context of tissue samples. Unlike traditional RNA sequencing, which loses information about where each gene is expressed, spatial transcriptomics preserves the physical location of gene activity in tissues. This helps researchers better understand how cells function within their native environments and interact with neighboring cells, which is especially valuable in fields like cancer research, neuroscience, and developmental biology. The method combines microscopy, molecular biology, and computational analysis to produce detailed maps of gene expression.
What are some common challenges faced by professionals working in spatial transcriptomics, and how can they be addressed?
Professionals in spatial transcriptomics often encounter challenges related to handling large, complex datasets and integrating spatial information with gene expression data. Ensuring high-quality sample preparation and mastering advanced imaging or sequencing technologies are also frequent hurdles. These challenges can be addressed by collaborating closely with multidisciplinary teams—including bioinformaticians, molecular biologists, and imaging specialists—and staying up-to-date with the latest software tools and protocols. Continuous learning and effective communication within the team are key to overcoming technical and analytical obstacles in this rapidly evolving field.
What are the key skills and qualifications needed to thrive as a Spatial Transcriptomics Scientist, and why are they important?
To thrive as a Spatial Transcriptomics Scientist, you need a strong background in molecular biology, genomics, and bioinformatics, typically supported by an advanced degree in a life science field. Familiarity with spatial transcriptomics platforms (such as 10x Genomics Visium), next-generation sequencing (NGS) technologies, and data analysis tools like R or Python is essential. Strong problem-solving skills, attention to detail, and effective communication are important soft skills for collaborating on interdisciplinary research projects. These skills and qualities are crucial for generating high-quality spatial gene expression data and translating findings into meaningful biological insights.
What are popular job titles related to Spatial Transcriptomics jobs in Alabama? For Spatial Transcriptomics jobs in Alabama, the most frequently searched job titles are:
What job categories do people searching Spatial Transcriptomics jobs in Alabama look for? The top searched job categories for Spatial Transcriptomics jobs in Alabama are:
School of Medicine - Open Rank - Neuro-oncology and Neurovascular Research
Birmingham, AL • On-site
Full-time
Posted 2 days ago
University Of Alabama At Birmingham rating
7.7
Based on 43 frontline employees who took The Breakroom Quiz
217th of 539 rated colleges and universities
Job description
Position Information
School/College School of Medicine Title School of Medicine - Open Rank - Neuro-oncology and Neurovascular Research Assignment Category Full-Time Rank Open Rank Tenure Status Open Tenure Payroll Status Faculty 12 Job Description The Department of Neurosurgery in the School of Medicine at the University of Alabama at Birmingham (UAB) has very active and well-established programs in both neuro-oncology and cerebrovascular clinical research, and we are broadening our laboratory research effort in these areas. We are looking to recruit highly motivated individuals to fill the following 4 open research positions for investigators holding MD, PhD, or MD/PhD degrees:
Tenured Professor level Neuro-oncology Researcher
Assistant or Associate Professor level Neuro-oncology Researcher
Instructor level Neuro-oncology Researcher to work with Dr. James M. Markert
Assistant, Associate or Tenured Professor level Cerebrovascular Researcher
The tenured and tenure track Neuro-oncology positions are open for broadly based research interests in the field of Neuro-oncology, including but not limited to both primary and metastatic adult brain tumors, genomics, proteomics/kinomics or epigenetics at the single cell level, immunobiology of host-tumor interactions and relevant patient-derived models of cancer. Successful applicants for the tenured and tenure-track Neuro-oncology positions will work in partnership with the UAB O'Neal Comprehensive Cancer Center Neuro-oncology Program. Added preference will be given to candidates whose research can synergize with existing UAB faculty to enable programmatic research support, e.g., multiple (principal) investigator grants.
The competitive candidate for the instructor Neuro-oncology position will have a research interest in primary and metastatic adult brain tumors, genomics, proteomics, kinomics and epigenetics, tumor immunology, and/or relevant patient-derived models of cancer. The major focus of the laboratory is oncolytic viral therapy and immunotherapy of cancers, for translational research. Applicants should be comfortable supervising and mentoring research staff, students, and residents. Common assays in the laboratory include tissue culture, viral culture, PCR, RT-PCR, cloning and oncolytic viral construction/engineering, ELISA, Western blotting, Southern blotting, mouse surgery and necropsy, flow cytometry, immunohistochemistry, and fluorescence microscopy. The laboratory also requires familiarity with biostatistics and enough familiarity with bioinformatics to be able to either code or work with UAB bioinformatics to perform a variety of clustering algorithms and deconvolution analyses to be performed on pre and post-treatment specimens. The laboratory is moving to a larger involvement in single-cell analyses and spatial transcriptomics and the successful candidate should be prepared to develop knowledge and skills in these areas.
Competitive candidates for the cerebrovascular position will have areas of interest that include but are not limited to: protective effects of ischemic preconditioning; endothelial dysfunction in ischemic and hemorrhagic stroke; role of inflammation in stroke, mechanisms of angiogenesis and arteriogenesis in chronic ischemia, and platelet/surface interaction. The successful applicant will join a productive and collaborative interdisciplinary research team consisting of investigators in the Departments of Neurosurgery, Neurology and Radiology at UAB. We will provide ample opportunity for developing independent work with state-of-the-art equipment, facilities, and analytical methods.
Ideally these positions will be filled by candidates devoting their full effort towards research, with no clinical duties. Fractional effort towards clinical duties is possible if it meshes with the plans of candidates seeking the tenured and tenure-track positions.
The University of Alabama at Birmingham (UAB) is a research university and academic health center that discovers, teaches, and applies knowledge for the intellectual, cultural, social, and economic benefit of Birmingham, the state, and beyond. UAB is internationally renowned for its intensely collaborative culture that has - for more than five decades - produced breakthroughs in education, health care, research, and service. UAB was ranked #1 in the United States, and in the top 10 worldwide, in the Times Higher Education World University Rankings, 2018 Young University Rankings.
UAB Medicine is the third largest public academic medical center in the country, with more than 1,900 beds and almost 18,000 employees. UAB Hospital is the centerpiece of the UAB Health System and is the teaching hospital for the UAB School of Medicine. Situated among major research centers and clinics, UAB Hospital provides patients with a complete range of primary and specialty care services, as well as the most up-to-date treatments and innovations in health care. In addition to UAB Hospital, UAB Medicine includes The Kirklin Clinicof UAB Hospital, UAB Callahan Eye Hospital, as well as several primary and specialty care clinics, a dozen member and affiliate hospitals within Alabama, more than 10 cancer associates in the Southeast, and the Viva Health HMO.
Located in the heart of the Southeast, Birmingham is a short drive from Atlanta, Nashville, Chattanooga, New Orleans, Memphis and Gulf Coast beaches. Some of the most beautiful suburbs in the United States surround the city. With its picturesque surroundings, Birmingham has been recognized as an "All American City", one of the top ten American cities to live and work, and one of the top ten entrepreneurial and job growth hot spots in America. The combination of pleasant weather, geography, diverse culture, activities, and lifestyle make this city a wonderful place to live, raise a family, and practice medicine.
For additional information about our department, please visit our website at https://www.uab.edu/medicine/neurosurgery/.
Interested candidates should apply here: http://uab.peopleadmin.com/postings/5204 by submitting an online application to include a cover letter, curriculum vitae, and the names of three references. Evaluation of applications will occur as they are received and will continue until the position is filled.
Required Qualifications Tenured Professor level Neuro-oncology Researcher
Assistant or Associate Professor level Neuro-oncology Researcher
Instructor level Neuro-oncology Researcher to work with Dr. James M. Markert
Assistant, Associate or Tenured Professor level Cerebrovascular Researcher
The tenured and tenure track Neuro-oncology positions are open for broadly based research interests in the field of Neuro-oncology, including but not limited to both primary and metastatic adult brain tumors, genomics, proteomics/kinomics or epigenetics at the single cell level, immunobiology of host-tumor interactions and relevant patient-derived models of cancer. Successful applicants for the tenured and tenure-track Neuro-oncology positions will work in partnership with the UAB O'Neal Comprehensive Cancer Center Neuro-oncology Program. Added preference will be given to candidates whose research can synergize with existing UAB faculty to enable programmatic research support, e.g., multiple (principal) investigator grants.
The competitive candidate for the instructor Neuro-oncology position will have a research interest in primary and metastatic adult brain tumors, genomics, proteomics, kinomics and epigenetics, tumor immunology, and/or relevant patient-derived models of cancer. The major focus of the laboratory is oncolytic viral therapy and immunotherapy of cancers, for translational research. Applicants should be comfortable supervising and mentoring research staff, students, and residents. Common assays in the laboratory include tissue culture, viral culture, PCR, RT-PCR, cloning and oncolytic viral construction/engineering, ELISA, Western blotting, Southern blotting, mouse surgery and necropsy, flow cytometry, immunohistochemistry, and fluorescence microscopy. The laboratory also requires familiarity with biostatistics and enough familiarity with bioinformatics to be able to either code or work with UAB bioinformatics to perform a variety of clustering algorithms and deconvolution analyses to be performed on pre and post-treatment specimens. The laboratory is moving to a larger involvement in single-cell analyses and spatial transcriptomics and the successful candidate should be prepared to develop knowledge and skills in these areas.
Competitive candidates for the cerebrovascular position will have areas of interest that include but are not limited to: protective effects of ischemic preconditioning; endothelial dysfunction in ischemic and hemorrhagic stroke; role of inflammation in stroke, mechanisms of angiogenesis and arteriogenesis in chronic ischemia, and platelet/surface interaction. The successful applicant will join a productive and collaborative interdisciplinary research team consisting of investigators in the Departments of Neurosurgery, Neurology and Radiology at UAB. We will provide ample opportunity for developing independent work with state-of-the-art equipment, facilities, and analytical methods.
Ideally these positions will be filled by candidates devoting their full effort towards research, with no clinical duties. Fractional effort towards clinical duties is possible if it meshes with the plans of candidates seeking the tenured and tenure-track positions.
The University of Alabama at Birmingham (UAB) is a research university and academic health center that discovers, teaches, and applies knowledge for the intellectual, cultural, social, and economic benefit of Birmingham, the state, and beyond. UAB is internationally renowned for its intensely collaborative culture that has - for more than five decades - produced breakthroughs in education, health care, research, and service. UAB was ranked #1 in the United States, and in the top 10 worldwide, in the Times Higher Education World University Rankings, 2018 Young University Rankings.
UAB Medicine is the third largest public academic medical center in the country, with more than 1,900 beds and almost 18,000 employees. UAB Hospital is the centerpiece of the UAB Health System and is the teaching hospital for the UAB School of Medicine. Situated among major research centers and clinics, UAB Hospital provides patients with a complete range of primary and specialty care services, as well as the most up-to-date treatments and innovations in health care. In addition to UAB Hospital, UAB Medicine includes The Kirklin Clinicof UAB Hospital, UAB Callahan Eye Hospital, as well as several primary and specialty care clinics, a dozen member and affiliate hospitals within Alabama, more than 10 cancer associates in the Southeast, and the Viva Health HMO.
Located in the heart of the Southeast, Birmingham is a short drive from Atlanta, Nashville, Chattanooga, New Orleans, Memphis and Gulf Coast beaches. Some of the most beautiful suburbs in the United States surround the city. With its picturesque surroundings, Birmingham has been recognized as an "All American City", one of the top ten American cities to live and work, and one of the top ten entrepreneurial and job growth hot spots in America. The combination of pleasant weather, geography, diverse culture, activities, and lifestyle make this city a wonderful place to live, raise a family, and practice medicine.
For additional information about our department, please visit our website at https://www.uab.edu/medicine/neurosurgery/.
Interested candidates should apply here: http://uab.peopleadmin.com/postings/5204 by submitting an online application to include a cover letter, curriculum vitae, and the names of three references. Evaluation of applications will occur as they are received and will continue until the position is filled.
Applicants must have an MD, PhD, or MD/PhD.
Preferred Qualifications The ideal candidate is an individual with a successful record of external awards,
publications, and a productive lab.
publications, and a productive lab.
Posting Detail Information
Posting Number F2097P Open Date 04/01/2023 Close Date Open Until Filled Yes Nondiscrimination Statement UAB is an Equal Employment/Equal Educational Opportunity Institution dedicated to providing equal opportunities and equal access to all individuals regardless of race, color, religion, ethnic or national origin, sex (including pregnancy), genetic information, age, disability, religion, and veteran's status. As required by Title IX, UAB prohibits sex discrimination in any education program or activity that it operates. Individuals may report concerns or questions to UAB's Assistant Vice President and Senior Title IX Coordinator. The Title IX notice of nondiscrimination is located at uab.edu/titleix.
Special Instructions to Applicants Pre-employment Background Check A pre-employment background check investigation is performed on candidates selected for employment.
Drug/Nicotine Screen (if applicable) A pre-employment background investigation is performed on candidates selected for employment. Physicians and other clinical faculty candidates who will be employed by the University of Alabama Health Services Foundation (UAHSF) or other UAB Medicine entities, must successfully complete a pre-employment drug screen to be hired.
About University of Alabama at Birmingham For additional information about our department, please visit our website at https://www.uab.edu/medicine/neurosurgery/.
To learn more about the University of Alabama at Birmingham click here.
To learn more about the University of Alabama at Birmingham click here.
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The University of Alabama at Birmingham is the heartbeat of Birmingham and an integral medical leader in the Southeast. The Birmingham campus is within walking distance of some of the best parks, entertainment, and dining in the region. UAB's three regional campuses expand their academic reach and responsibilities in addition to educating physicians in rural and underserved areas of the state. UAB is experiencing major and sustained investment and growth, due both to its exceptional research faculty and its culture of collaboration. Through concerted and strategic investments in its clinical and research enterprise, UAB has undergone an amazing transformation in the past five years and has strengthened its status and reputation as a leader in medical training, biomedical discovery, innovation, and patient care.
Industry
Colleges, universities, and professional schools
Company size
10,000+ Employees
Headquarters location
Birmingham, AL, US
Year founded
1859