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Small Molecule Drug Development Jobs in Indiana (NOW HIRING)

micro1 AI

Bioinformatics Software Engineer

Evansville, IN · Remote

$80 - $110/hr

Analyze and interpret small-molecule and drug discovery datasets using advanced computational biology, bioinformatics, and cheminformatics methods. * Curate, annotate, and validate chemical and ...

micro1 AI

Cheminformatics Specialist - Remote

Fishers, IN · Remote

$80 - $110/hr

Analyze and interpret small-molecule and drug discovery datasets using advanced computational biology, bioinformatics, and cheminformatics methods. * Curate, annotate, and validate chemical and ...

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Small Molecule Drug Development information

What is small molecule drug development?

Small molecule drug development is the process of discovering, designing, and bringing to market pharmaceutical compounds that have low molecular weight and can easily enter cells to affect biological processes. These drugs are typically administered orally and are used to treat a wide range of diseases. The development process involves several stages, including target identification, compound screening, preclinical testing, and clinical trials before regulatory approval. Small molecule drugs are distinct from biologics, which are larger and more complex molecules like proteins or antibodies.

What degree do you need to work in small molecule drug development?

A career in small molecule drug development typically requires at least a bachelor's degree in chemistry, biochemistry, pharmaceutical sciences, or a related field. Advanced roles often prefer or require a master's or Ph.D. degree, along with experience in laboratory research, drug synthesis, and analytical techniques.

What are some common challenges faced by professionals in small molecule drug development, and how can they be addressed?

Professionals in small molecule drug development often face challenges such as balancing tight project timelines with rigorous regulatory requirements and managing cross-disciplinary collaboration between chemistry, biology, and clinical teams. Navigating unexpected results in preclinical or clinical studies can also require rapid problem-solving and adaptation. Building strong communication skills and staying updated on the latest regulatory guidelines and scientific advances can help address these challenges. Working closely with team members from diverse backgrounds fosters innovative solutions and keeps projects on track.

What are the key skills and qualifications needed to thrive in small molecule drug development, and why are they important?

To thrive in Small Molecule Drug Development, you need a strong background in chemistry, pharmacology, and molecular biology, typically supported by an advanced degree such as a Ph.D. or M.S. in a related field. Proficiency with laboratory techniques, analytical instrumentation (like HPLC and mass spectrometry), and drug discovery software is essential. Strong problem-solving skills, collaboration, and project management abilities help professionals excel in multidisciplinary teams. These skills and qualities are critical for efficiently advancing compounds through the drug discovery pipeline and ensuring compliance with regulatory standards.

What are popular job titles related to Small Molecule Drug Development jobs in Indiana?

For Small Molecule Drug Development jobs in Indiana, the most frequently searched job titles are:

What job categories do people searching Small Molecule Drug Development jobs in Indiana look for?

The top searched job categories for Small Molecule Drug Development jobs in Indiana are:

What cities in Indiana are hiring for Small Molecule Drug Development jobs?

Cities in Indiana with the most Small Molecule Drug Development job openings:

Small Molecule Drug Development jobs near you
Infographic showing various Small Molecule Drug Development job openings in Indiana as of June 2026, with employment types broken down into 1% As Needed, 77% Full Time, 21% Part Time, and 1% Contract. Highlights an 94% Physical, 1% Hybrid, and 5% Remote job distribution.

Director, Global Regulatory Affairs - Chemistry, Manufacturing and Controls (CMC), Platform Innovati

Eli Lilly and Company

Indianapolis, IN • On-site

$143K - $189K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 23 days ago

Eli Lilly and Company rating

8.8

Company rating: 8.8 out of 10

Based on 63 frontline employees who took The Breakroom Quiz

11th of 86 rated pharmaceutical

Job description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
This role provides strategic, tactical and operational regulatory CMC leadership across therapeutic modalities and manufacturing technologies to expedite development of the small molecule portfolio and to support clinical trial applications, market registrations, and post approval submissions. This is accomplished through a strong working knowledge of global regulations, guidelines, and regulatory precedent coupled with deep technical knowledge of CMC development and manufacturing processes.
Key Responsibilities
  • Deep technical knowledge of small molecule CMC drug development and manufacturing sciences across modalities and platforms (drug substance, drug product, analytical sciences).
  • Knowledge of global CMC regulatory requirements and guidelines for conducting clinical trials and obtaining global product registrations and maintaining approved registrations.
  • Development and implementation of innovative regulatory strategies and platform approaches based on changes in external environment (new guidance, evolving expectations, and regulatory precedent).
  • Provide regulatory guidance to allow CMC development teams to make well-informed decisions on development or product lifecycle planning.
  • Leads preparation, critical review, and approval of CMC documents for global regulatory submissions and responses, including clinical trial applications, marketing applications, variations/supplements, and health authority information requests.
  • Takes a proactive leadership role in the critical review of molecule specific CMC development and lifecycle strategies.
  • Provides high quality, timely and clear regulatory advice to allow project teams to make well-informed decisions on development or product lifecycle planning.
  • Makes decisions on CMC regulatory strategies impacting product submissions across geographies and networks for alignment with CMC team members.

Basic Qualifications/Requirements
  • B.S. degree in a science, engineering, or a STEM related field (advanced degree preferred). Fields of study include Chemistry, Pharmaceutics, Chemical Engineering, Analytical Sciences, Biology, or similar.
  • 10+ years of Regulatory CMC or technical CMC experience supporting clinical phases of development and/or commercialization of synthetic molecules. Those with greater than ten years of experience are encouraged to apply.

Additional Skills/Preferences
  • Experience authoring CMC submission content, and involvement in clinical trial applications/marketing authorization application processes including response to questions.
  • Knowledge of major market procedures, regulations, and practices. Awareness of evolving regulatory initiatives.
  • Relevant experience in synthetic molecule drug substance and/or drug product development, commercialization, or manufacturing.
  • Demonstrated deep knowledge of the synthetic molecule drug development process.
  • Extensive prior regulatory experience handling complex regulatory submission strategies or equivalent combination of technical and regulatory guidance knowledge and experience.
  • Experience planning for and participating in Health Authority meetings.
  • Demonstrated ability to assess and manage risk in a highly regulated environment.
  • Demonstrated strong written, spoken and presentation communication skills.
  • Demonstrated leadership behaviors and negotiation and influence skills.
  • Demonstrated attention to detail.
  • Demonstrated effective teamwork skills; able to adapt to diverse interpersonal styles.

Additional Information
  • Position Location: Indianapolis, IN. A remote option may be considered. Relocation assistance is provided.
  • Travel: minimal within the US

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$148,500 - $257,400
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
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About Eli Lilly

Sourced by ZipRecruiter

Eli Lilly, based in Indianapolis, IN, US, is one of the pioneers in the pharmaceutical industry with a rich history dating back to 1876. This global pharmaceutical company focuses on discovering, developing, manufacturing and selling pharmaceutical products in approximately 120 countries. The company's product categories include endocrinology, oncology, cardiovascular, neuroscience, and immunology. Having invested over $9 billion in research and development in the past decade, Eli Lilly is also committed to creating high-quality medicines that meet real needs. As a recipient of several awards and recognitions, Eli Lilly is known for its focus on life-saving research and drug development. Their mission is to make medicines that help people live longer, healthier, and more active lives.

Industry

Pharmaceutical product wholesalers

Company size

10,000+ Employees

Headquarters location

Indianapolis, IN, US

Year founded

1876

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