The candidate should be well-versed in small molecule drug discovery and bring experience with a ... Ensuring effective communication and coordination with departmental and company-wide leaders on ...
The candidate should be well-versed in small molecule drug discovery and bring experience with a ... Ensuring effective communication and coordination with departmental and company-wide leaders on ...
Director, Small Molecule Discovery Biology (Inflammation & Autoimmunity)
San Francisco, CA Β· On-site
$200K - $240K/yr
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients ... The candidate should be well-versed in small molecule drug discovery and bring experience with a ...
Director, Small Molecule Discovery Biology (Inflammation & Autoimmunity)
San Francisco, CA Β· On-site
$200K - $240K/yr
Alumis Inc. is a precision medicines company with the mission to transform the lives of patients ... The candidate should be well-versed in small molecule drug discovery and bring experience with a ...
HVAC Installer with Experience
$25 - $40/hr
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HVAC Installer with Experience
$25 - $40/hr
Company Description We are a small company located in Redwood City and looking to expand our staff. The company is growing fast and don't have enough staff. Our company is looking to add a new crew ...
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Redwood City, CA Β· On-site
$25 - $40/hr
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Redwood City, CA Β· On-site
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San Jose, CA Β· On-site
$130 - $160/hr
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San Jose, CA Β· On-site
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Foster City, CA Β· Hybrid
$20.50 - $27.75/hr
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Foster City, CA Β· Hybrid
$20.50 - $27.75/hr
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Foster City, CA Β· On-site
$20.50 - $27.75/hr
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Foster City, CA Β· On-site
$20.50 - $27.75/hr
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$25 - $30/hr
Excellent written and verbal communication skills Company Description We are a small company that has the attention to grow. We are a christian Academy that would like to work with a team that is ...
Quick apply
Preschool Teacher
$25 - $30/hr
Excellent written and verbal communication skills Company Description We are a small company that has the attention to grow. We are a christian Academy that would like to work with a team that is ...
OTR CDL A Owner Operator Truck Driver, Small Fleets, Company Drivers We speak your language allowing us to provide excellent service to multilingual drivers Arabic Armenian Cambodian Chinese English ...
OTR CDL A Owner Operator Truck Driver, Small Fleets, Company Drivers We speak your language allowing us to provide excellent service to multilingual drivers Arabic Armenian Cambodian Chinese English ...
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San Francisco, CA Β· On-site
$25 - $30/hr
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Quick apply
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San Francisco, CA Β· On-site
$25 - $30/hr
Excellent written and verbal communication skills Company Description We are a small company that has the attention to grow. We are a christian Academy that would like to work with a team that is ...
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Fremont, CA Β· On-site
$25 - $30/hr
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Fremont, CA Β· On-site
$25 - $30/hr
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Though we're the nation's leading landscape company, we maintain a small company feel and supportive environment that makes our team members feel at home. If you're looking to join a crew of talented ...
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$155K - $159K/yr
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Milpitas, CA Β· On-site
$155K - $159K/yr
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San Francisco, CA Job Type: Full-Time * Hands-βon experience with structural and mechanical systems,β ideally in propulsion or aerospace hardware at a startup / small company.β Must be ...
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Senior Scientist I Analytical Development
$112K - $135K/yr
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Senior Scientist I Analytical Development
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San Jose, CA Β· On-site
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San Jose, CA Β· On-site
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South San Francisco, CA Β· Hybrid
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South San Francisco, CA Β· Hybrid
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San Jose, CA Β· On-site
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Quick apply
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San Jose, CA Β· On-site
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$200K - $240K/yr
Full-time
Re-posted 2 days ago
Job description
The Alumis team seeks a highly motivated Director in autoimmune discovery biology. The candidate should be well-versed in small molecule drug discovery and bring experience with a variety of target classes and modalities. The individual will take responsibility for important project-level biochemistry and biology efforts advancing our early portfolio of small molecule autoimmune therapies, as well as mentoring junior staff. The ideal candidate will bring expertise drawn from different areas of biology and immunology, such as biochemistry, pharmacology, cell biology, molecular biology, and chemical biology/proteomics. Prior experience will ideally span across the stages of drug discovery from lead finding through early clinical development.
Key Responsibilities:
- Taking biology department responsibility in discovery-stage small molecule projects including conceptualizing project strategy, recognizing knowledge gaps, formulating screening paradigms, overseeing SAR generation, coordinating among project stakeholders, and identifying potential new targets
- Overseeing development of both biochemical and cellular read-outs to support small molecule drug discovery efforts Support characterization of small molecule clinical candidates by employing autoimmune disease models and developing clinically relevant PD assays
- Providing both direct and indirect supervision of laboratory-based biology staff
- Manage external biology studies performed at CROs.
- Collaborating effectively with cross-functional teams including medicinal chemistry, DMPK, and preclinical development.
- Ensuring effective communication and coordination with departmental and company-wide leaders on project strategy and progress toward goals
Ideal candidate:
- PhD with 8+ years biopharma work experience in immunology-related small molecule drug discovery
- Prior experience with function-level oversight of project biology and/or biochemistry efforts, or overall project team leadership
- Knowledge of and hands on experience with emerging areas of small molecule drug discovery, such as protein-protein interaction inhibitors, degraders and molecular glues, and transcription factors
- Expertise spanning from early-stage target discovery and validation through early clinical development
- Awareness of methods for compound screening, characterizing mechanism of action, transcriptomics, and proteomics
- Familiarity with autoimmune disease biology including in vitro and in vivo immunology models, immortalized cell lines, isolation and characterization of primary immune cells, RNA-Seq, and cytokine detection methodologies
- Prior management of CRO collaborations, with an existing familiarity of a wide variety of biology CROs
- Excellent interpersonal skills with the ability to work both independently and cross-functionally to advance drug discovery programs; experience working with academic collaborators is a plus.
- Successful direct and indirect supervision of junior staff members
- Familiarity and enthusiasm for working in a small company environment
- Track record of scientific achievement and innovation
The salary range for this position is $200,000 USD to $240,000 USD annually. This salary range is an estimate, and the actual salary may very based on the Company's compensation practices. Β