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Single Cell Spatial Transcriptomics Jobs in Needham, MA

MIT Human Resources

Research Scientist 1

Cambridge, MA · On-site

RESEARCH SCIENTIST 1 , Computer Science and Artificial Intelligence Lab, will lead computational analyses of large-scale single-cell and spatial multi-omic datasets derived from human postmortem ...

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Single Cell Spatial Transcriptomics information

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How much do single cell spatial transcriptomics jobs pay per hour?

As of Jun 26, 2026, the average hourly pay for single cell spatial transcriptomics in Needham, MA is $23.58, according to ZipRecruiter salary data. Most workers in this role earn between $18.32 and $29.57 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Single Cell Spatial Transcriptomics Scientist, and why are they important?

To thrive as a Single Cell Spatial Transcriptomics Scientist, you need a strong background in molecular biology, genomics, and bioinformatics, typically supported by an advanced degree (PhD or MSc) in a relevant field. Familiarity with high-throughput sequencing platforms, spatial transcriptomics technologies (like 10x Genomics Visium or NanoString GeoMx), and data analysis tools such as R or Python is essential. Critical thinking, problem-solving, and effective communication are crucial soft skills for interpreting complex data and collaborating in multidisciplinary teams. These skills and qualities are vital for generating reliable insights into cellular function and spatial organization, which drive innovative research and discovery.

What are some typical challenges faced by professionals working in Single Cell Spatial Transcriptomics, and how can they be addressed?

Professionals in Single Cell Spatial Transcriptomics often encounter challenges related to handling large, complex data sets and integrating spatial information with single-cell transcriptomic profiles. These tasks demand strong computational skills and close collaboration with bioinformaticians and other researchers. Effective communication within interdisciplinary teams is essential to ensure experimental design aligns with downstream analysis needs. Staying updated with rapidly evolving technologies and best practices also helps professionals overcome technical hurdles and produce reliable, high-impact results.

What is single cell spatial transcriptomics?

Single cell spatial transcriptomics is a cutting-edge technique that allows researchers to analyze gene expression in individual cells while preserving their spatial location within a tissue. This method combines the high-resolution insights of single-cell RNA sequencing with spatial information, enabling scientists to understand how cells interact and organize within their native environments. It is widely used in biomedical research to study tissue architecture, disease mechanisms, and cellular heterogeneity.
What job categories do people searching Single Cell Spatial Transcriptomics jobs in Needham, MA look for? The top searched job categories for Single Cell Spatial Transcriptomics jobs in Needham, MA are:
What cities near Needham, MA are hiring for Single Cell Spatial Transcriptomics jobs? Cities near Needham, MA with the most Single Cell Spatial Transcriptomics job openings:
Single Cell Spatial Transcriptomics jobs near you
Sr Scientist, Genomic Sciences and Target Discovery

Sr Scientist, Genomic Sciences and Target Discovery

Alkermes

Waltham, MA • On-site

$151K - $170K/yr

Full-time

Posted 15 days ago

Job description


Senior Scientist - Genome Editing, Genomic Sciences and Target Discovery
Job Description:
We are seeking an enthusiastic and highly motivated Senior Scientist to join the Genomic Sciences and Target Discovery team within Alkermes R&D, focusing on the application of genome-editing technologies to validate therapeutic hypotheses in vitro and in vivo for central nervous system (CNS) disorders.
Key Responsibilities:
  • Design, develop, and execute CRISPR-based functional genomics strategies to validate therapeutic hypotheses in vitro and in preclinical models of CNS diseases.
  • Utilize CRISPR/Cas9, CRISPRa, and CRISPRi approaches to modulate gene expression and investigate target biology in the context of neuroanatomy and neurocircuitry.
  • Develop and optimize CRISPR delivery methodologies, including viral and non-viral delivery systems, for precise gene editing in the CNS.
  • Establish and validate CRISPR-edited rodent models using molecular, cellular, and behavioral readouts to assess target engagement and functional outcomes.
  • Collaborate cross-functionally with neuroscience, pharmacology, and translational teams to integrate functional genomics insights into drug discovery programs.
  • Perform molecular and cellular assays, including PCR, NGS, immunohistochemistry, and single-cell sequencing, to confirm CRISPR-mediated gene modifications.
  • Maintain detailed records of experimental design, execution, and data interpretation in accordance with corporate documentation standards.
  • Keep abreast of emerging CRISPR technologies and functional genomics advancements to drive innovation within the team.
  • Effectively communicate findings and recommendations to internal and external stakeholders.

Required Qualifications:
  • Ph.D. in Neuroscience, Molecular Biology, Genomics, or a related field with a minimum of 3 years of relevant experience in functional genomics, preferably within industry-based CNS drug discovery and development.
  • Proficiency in human (Mendelian/population genetics) and model organism genetics
  • Expertise in CRISPR-based gene editing techniques, including CRISPR/Cas9, CRISPRa, and CRISPRi.
  • Experience with in vivo CRISPR delivery methods such as AAV, lipid nanoparticles, or electroporation for targeting CNS circuits.
  • Strong background in neuroanatomy and neurocircuitry, with experience in functional validation of gene edits in preclinical models.
  • Proficiency in standard molecular biology and tissue culture techniques, including developing and maintaining CRISPR-edited cell lines.
  • Familiarity with in vivo rodent models, behavioral assays, and CNS-relevant phenotypic assessments.
  • Strong data analysis and interpretation skills, with experience using bioinformatics tools for genomic analysis.
  • Excellent communication and collaboration skills in a cross-disciplinary research environment.

Preferred Qualifications:
  • Experience with single-cell RNA sequencing, spatial transcriptomics, or electrophysiological techniques to assess gene function in CNS models.
  • Proficiency with computational tools (Python, R, or Unix CLI) for analyzing CRISPR screening data.

The annual base salary for this position ranges from $151,000 to $170,000. In addition, this position is eligible for an annual performance pay bonus. Exact compensation may vary based on skills, training, knowledge, and experience. Alkermes offers a competitive benefits package. Additional details can be found on our careers website: www.alkermes.com/careers#working-here
This role will be onsite 5 days per week.
#LI-RS1
#LI-Onsite
About Us
Why join Team Alkermes?
Alkermes applies its decades of deep neuroscience expertise to develop medicines designed to help people living with complex and difficult-to-treat psychiatric and neurological disorders. A global biopharmaceutical company, headquartered in Ireland with U.S. locations in Massachusetts and Ohio, we seek to make a meaningful difference in the way people manage their diseases. We have a portfolio of proprietary commercial products for the treatment of alcohol dependence, opioid dependence, schizophrenia, bipolar I disorder and narcolepsy, and a pipeline of clinical and preclinical candidates in development for various psychiatric and neurological disorders.
We are proud to have been recognized as an employer of choice by many national organizations. In 2024 and 2025, we were certified as a Great Place to Work in the U.S. and named one of Massachusetts' Top Places to Work by the Boston Globe, a Best Place to Work in Greater Cincinnati by the Cincinnati Business Courier and recognized as a Best Place to Work in BioPharma by Fortune Magazine.
Alkermes, Inc. is an equal employment opportunity employer and does not discriminate against any qualified applicant or employee because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, gender expression and identity, disability, genetic information, veteran status, military status, application for military service or any other characteristic protected by local, state or federal law. Alkermes also complies with all work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Alkermes is an E-Verify employer.

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