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Single Cell Spatial Transcriptomics Jobs in Needham, MA

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Patient-Centered Prediction Lead

Boston, MA · On-site

... bulk and single-cell, spatial transcriptomics, methylation, imaging) * Credible as a thought partner with senior R&D leaders on patient-centered prediction topics; able to engage across both ...

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Single Cell Spatial Transcriptomics information

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How much do single cell spatial transcriptomics jobs pay per hour?

As of Jun 25, 2026, the average hourly pay for single cell spatial transcriptomics in Needham, MA is $23.58, according to ZipRecruiter salary data. Most workers in this role earn between $18.32 and $29.57 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Single Cell Spatial Transcriptomics Scientist, and why are they important?

To thrive as a Single Cell Spatial Transcriptomics Scientist, you need a strong background in molecular biology, genomics, and bioinformatics, typically supported by an advanced degree (PhD or MSc) in a relevant field. Familiarity with high-throughput sequencing platforms, spatial transcriptomics technologies (like 10x Genomics Visium or NanoString GeoMx), and data analysis tools such as R or Python is essential. Critical thinking, problem-solving, and effective communication are crucial soft skills for interpreting complex data and collaborating in multidisciplinary teams. These skills and qualities are vital for generating reliable insights into cellular function and spatial organization, which drive innovative research and discovery.

What are some typical challenges faced by professionals working in Single Cell Spatial Transcriptomics, and how can they be addressed?

Professionals in Single Cell Spatial Transcriptomics often encounter challenges related to handling large, complex data sets and integrating spatial information with single-cell transcriptomic profiles. These tasks demand strong computational skills and close collaboration with bioinformaticians and other researchers. Effective communication within interdisciplinary teams is essential to ensure experimental design aligns with downstream analysis needs. Staying updated with rapidly evolving technologies and best practices also helps professionals overcome technical hurdles and produce reliable, high-impact results.

What is single cell spatial transcriptomics?

Single cell spatial transcriptomics is a cutting-edge technique that allows researchers to analyze gene expression in individual cells while preserving their spatial location within a tissue. This method combines the high-resolution insights of single-cell RNA sequencing with spatial information, enabling scientists to understand how cells interact and organize within their native environments. It is widely used in biomedical research to study tissue architecture, disease mechanisms, and cellular heterogeneity.
What job categories do people searching Single Cell Spatial Transcriptomics jobs in Needham, MA look for? The top searched job categories for Single Cell Spatial Transcriptomics jobs in Needham, MA are:
What cities near Needham, MA are hiring for Single Cell Spatial Transcriptomics jobs? Cities near Needham, MA with the most Single Cell Spatial Transcriptomics job openings:
Single Cell Spatial Transcriptomics jobs near you
Research Associate II - Spatial Technology Platform

Research Associate II - Spatial Technology Platform

Broad Institute

Cambridge, MA • On-site

$58K - $80K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 3 days ago

Job description

General information
Location
Cambridge, MA
Ref #
44034
Job Family
Research
Date published
06/08/2026
Time Type
Full time
Pay Range
$58,000.00/yr - $80,667.00/yr
Description & Requirements
The Broad Institute of MIT & Harvard, a world leader in genetic research, is looking for an exceptional candidate to join the Spatial Technology Platform (STP). STP utilizes cutting-edge spatial profiling methods to generate highly multiplexed and multi-modal data sets at single-cell resolution as a high-throughput scaled service at the Broad Institute. In addition, our platform develops and pilots new technologies and capabilities that have potential for scaled service implementation, including cross-modality assays and technologies at precommercial stages. Our focus lies in highly multiplexed spatial transcriptomics alongside in situ proteomics and optical barcoding technologies for demultiplexing CRISPR perturbations. Our research and development efforts are increasingly directed toward profiling therapeutic candidates and their effects on cell-cell interactions and rescue of mechanisms and phenotypes underlying genetic disorders, immunological diseases, and cancer.
We are a team of academic researchers and professional scientists with diverse expertise in experimental biology, engineering, and computer science, fostering a collaborative and innovative environment. We are seeking a highly motivated individual to join the imaging group within our team and support workflows and quality control methods as we transition spatial transcriptomics assays to scaled service operations, pilot and develop combined multimodal assays, and develop techniques to troubleshoot spatial assays at intermediate points. We value strong teamwork, clear communication, and autonomy. While the role requires independent initiative and will be highly dynamic, you'll benefit from close mentorship and guidance from our senior researchers.
The Broad Institute fosters a vibrant and intellectually stimulating research environment with deep connections to leading academic institutions throughout the Boston area. This unique ecosystem provides you with exceptional opportunities to collaborate with renowned researchers, engage in pioneering scientific inquiry, and contribute to knowledge with the potential for global impact.
KEY RESPONSIBILITIES
  • Develop and evaluate methods to assess quality of input material for spatial transcriptomics assays - RNA extraction and DV200 profiling, H&E imaging, and RNAscope profiling.
  • Pilot methods to adapt spatial transcriptomics workflows for high-throughput profiling of cultured cells.
  • Implement imaging-based spatial profiling methods such as 10X Xenium in combination with other assays such as RNAscope and multiplexed immunofluorescence.
  • Support the platform's self-service imaging instrumentation through user training of widefield, confocal, and light sheet microscopy.
  • Attention to detail when troubleshooting and resolving issues in assays; ability to propose next steps or directions even when the path to an experimental goal is not clear.
  • Support of histology needs.
  • Flexibility in a rapidly changing environment.
  • Document, compile, and analyze experimental data.
  • Attend and present at team meetings to share results and ensure that projects support team goals.

QUALIFICATIONS
  • Bachelor's degree with at least 2 years of related work experience, or Master's degree.
  • Experience in molecular biology, biochemistry, biotechnology, or a related field.
  • Experience with fluorescence microscopy and imaging.
  • Strong wet lab skills and experience with tissue processing (histology) are required.
  • Experience in imaging or spatial genomics is highly desirable.
  • Great teamwork skills, including the ability to engage with external collaborators.
  • Highly independent and resourceful.
  • Computational analysis is a plus.

The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law.
At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits.
The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations.
Should you need a reasonable accommodation to complete the application or interview process, please contact recruiting@broadinstitute.org for assistance.

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